At the end of the match : exploring retirement of Italian football players

Retirement of Italian football players is unknown, thus, after analysing current literature about leaving from sport and using a Phenomenological-Interpretative approach we develop an explorative study on Italian former football players' experience of withdrawal. We interview 14 former players that competed in the highest level of Italian football Championship, to better understand their lived experience of retirement and compare it with literature. It emerges that the minority of football players choose voluntary to retire - except in the case when they enter into their Clubs as coaches or manager - and cannot plan retirement in advance; they share a strong athletic identity but the risk of identity foreclosure seems to be moderated by social support, especially from families and partners, while less from sport context (coach and teammates). Implications for future research in Italy and the work of sport psychologists and professional Clubs of football are discussed.La retirada de jugadores de fútbol en Italia es desconocida. Así, después de analizar la literatura actual y usando un enfoque fenomenológico-interpretativo, desarrollamos un estudio exploratorio sobre esta experiencia de los ex-jugadores de fútbol italiano. Entrevistamos a 14 ex-jugadores, que compitieron en el más alto nivel del Campeonato de Fútbol italiano, para comprender su experiencia de jubilación y compararla con la literatura. La minoría de jugadores de fútbol eligen voluntariamente retirarse - excepto en el caso de que entren a sus clubes como entrenadores o gestores - y no quieren planificar la jubilación anticipadamente. Comparten una fuerte identidad atlética, pero el riesgo de exclusión de identidad parece ser moderado por el apoyo social, especialmente de las familias, pero menos del contexto deportivo (entrenador y compañeros de equipo). Se discuten las implicaciones para futuras investigaciones en Italia y el trabajo de psicólogos deportivos y clubes profesionales de fútbol

Open field study of some Zea mays hybrids, lipid compounds and fumonisins accumulation

Lipid molecules are increasingly recognized as signals exchanged by organisms interacting in pathogenic and/or symbiotic ways. Some classes of lipids actively determine the fate of the interactions. Host cuticle/cell wall/membrane components such as sphingolipids and oxylipins may contribute to determining the fate of host–pathogen interactions. In the present field study, we considered the relationship between specific sphingolipids and oxylipins of different hybrids of Zea mays and fumonisin by F. verticillioides, sampling ears at different growth stages from early dough to fully ripe. The amount of total and free fumonisin differed significantly between hybrids and increased significantly with maize ripening. Oxylipins and phytoceramides changed significantly within the hybrids and decreased with kernel maturation, starting from physiological maturity. Although the correlation between fumonisin accumulation and plant lipid profile is certain, the data collected so far cannot define a cause-effect relationship but open up new perspectives. Therefore, the question—“Does fumonisin alter plant lipidome or does plant lipidome modulate fumonisin accumulation?”—is still open

Mono-and Bi-weekly hypofractionated radiation therapy for the treatment of epithelial skin cancer in very elderly patients

urs in the elderly population, sometimes in an advanced stage, when intensive treatments are needed. Radiotherapy can achieve high response rates. We evaluated efficacy and tolerability of hypofractionated radiotherapy in a population of very elderly patients with locally advanced epithelial skin cancer. Patients and Methods: Two different hypofractionated schedules were administered (21 patients): 6 Gy in 10 bi-weekly fractions (13 lesions) and 5 Gy in 12 bi-weekly fractions (13 lesions). Median age at treatment was 88 years, life expectancy was ≤5 years in 90.5%. Results: The overall response rate was 96.1%, with 92.4% complete responses. All patients experienced an improvement of their symptoms and a reduction of pain and medication. The median overall survival time was 28 months (95% confidence interval=4.7-51.2 months). At the time of analysis, 52.3% of patients had died. Conclusion: Hypofractionated radiotherapy is an effective option of treatment, with low toxicity and optimal results, and can also be safely administered to these frail patients. Epithelial skin cancer is a common neoplasm. The m

Carriera atletica e transizioni: uno sguardo psicosociale

La gestione della carriera richiede oggi un continuo lavoro di riprogettazione professionale e attraversamento di contesti. Le transizioni da una attività professionale ad un’altra rappresentano in particolare eventi critici, che necessitano di adeguato accompagnamento. Questo è tanto più vero in ambito sportivo, dove la “fine della carriera” è un momento relativamente precoce e spesso fonte di profonda sofferenza individuale. Il contributo offre una riflessione su questi temi e sulle prospettive di azione in ambito psicologico

Investigating the Paracrine Role of Perinatal Derivatives: Human Amniotic Fluid Stem Cell-Extracellular Vesicles Show Promising Transient Potential for Cardiomyocyte Renewal

Cardiomyocyte renewal represents an unmet clinical need for cardiac regeneration. Stem cell paracrine therapy has attracted increasing attention to resurge rescue mechanisms within the heart. We previously characterized the paracrine effects that human amniotic fluid-derived stem cells (hAFSC) can exert to provide cardioprotection and enhance cardiac repair in preclinical models of myocardial ischemia and cardiotoxicity. Here, we analyze whether hAFSC secretome formulations, namely, hAFSC conditioned medium (hAFSC-CM) over extracellular vesicles (hAFSC-EVs) separated from it, can induce cardiomyocyte renewal. c-KIT+ hAFSC were obtained by leftover samples of II trimester prenatal amniocentesis (fetal hAFSC) and from clinical waste III trimester amniotic fluid during scheduled C-section procedures (perinatal hAFSC). hAFSC were primed under 1% O2 to enrich hAFSC-CM and EVs with cardioactive factors. Neonatal mouse ventricular cardiomyocytes (mNVCM) were isolated from cardiac tissue of R26pFUCCI2 mice with cell cycle fluorescent tagging by mutually exclusive nuclear signal. mNVCM were stimulated by fetal versus perinatal hAFSC-CM and hAFSC-EVs to identify the most promising formulation for in vivo assessment in a R26pFUCCI2 neonatal mouse model of myocardial infarction (MI) via intraperitoneal delivery. While the perinatal hAFSC secretome did not provide any significant cardiogenic effect, fetal hAFSC-EVs significantly sustained mNVCM transition from S to M phase by 2-fold, while triggering cytokinesis by 4.5-fold over vehicle-treated cells. Treated mNVCM showed disorganized expression of cardiac alpha-actinin, suggesting cytoskeletal re-arrangements prior to cell renewal, with a 40% significant downregulation of Cofilin-2 and a positive trend of polymerized F-Actin. Fetal hAFSC-EVs increased cardiomyocyte cell cycle progression by 1.8-fold in the 4-day-old neonatal left ventricle myocardium short term after MI; however, such effect was lost at the later stage. Fetal hAFSC-EVs were enriched with a short isoform of Agrin, a mediator of neonatal heart regeneration acting by YAP-related signaling; yet in vitro application of YAP inhibitor verteporfin partially affected EV paracrine stimulation on mNVCM. EVs secreted by developmentally juvenile fetal hAFSC can support cardiomyocyte renewal to some extension, via intercellular conveyance of candidates possibly involving Agrin in combination with other factors. These perinatal derivative promising cardiogenic effects need further investigation to define their specific mechanism of action and enhance their potential translation into therapeutic opportunity

AIRO Breast Cancer Group Best Clinical Practice 2022 Update

Introduction: Breast cancer is the most common tumor in women and represents the leading cause of cancer death. Radiation therapy plays a key-role in the treatment of all breast cancer stages. Therefore, the adoption of evidence-based treatments is warranted, to ensure equity of access and standardization of care in clinical practice.Method: This national document on the highest evidence-based available data was developed and endorsed by the Italian Association of Radiation and Clinical Oncology (AIRO) Breast Cancer Group.We analyzed literature data regarding breast radiation therapy, using the SIGN (Scottish Intercollegiate Guidelines Network) methodology (www.sign.ac.uk). Updated findings from the literature were examined, including the highest levels of evidence (meta-analyses, randomized trials, and international guidelines) with a significant impact on clinical practice. The document deals with the role of radiation therapy in the treatment of primary breast cancer, local relapse, and metastatic disease, with focus on diagnosis, staging, local and systemic therapies, and follow up. Information is given on indications, techniques, total doses, and fractionations.Results: An extensive literature review from 2013 to 2021 was performed. The work was organized according to a general index of different topics and most chapters included individual questions and, when possible, synoptic and summary tables. Indications for radiation therapy in breast cancer were examined and integrated with other oncological treatments. A total of 50 questions were analyzed and answered.Four large areas of interest were investigated: (1) general strategy (multidisciplinary approach, contraindications, preliminary assessments, staging and management of patients with electronic devices); (2) systemic therapy (primary, adjuvant, in metastatic setting); (3) clinical aspects (invasive, non-invasive and micro-invasive carcinoma; particular situations such as young and elderly patients, breast cancer in males and cancer during pregnancy; follow up with possible acute and late toxicities; loco-regional relapse and metastatic disease); (4) technical aspects (radiation after conservative surgery or mastectomy, indications for boost, lymph node radiotherapy and partial breast irradiation).Appendixes about tumor bed boost and breast and lymph nodes contouring were implemented, including a dedicated web application. The scientific work was reviewed and validated by an expert group of breast cancer key-opinion leaders.Conclusions: Optimal breast cancer management requires a multidisciplinary approach sharing therapeutic strategies with the other involved specialists and the patient, within a coordinated and dedicated clinical path. In recent years, the high-level quality radiation therapy has shown a significant impact on local control and survival of breast cancer patients. Therefore, it is necessary to offer and guarantee accurate treatments according to the best standards of evidence-based medicine

Price discrimination and product quality under opt-in privacy regulation

We study how an opt-in regime of privacy regulation, which limits the scope for online price discrimination, affects product quality and consumer surplus. When consumers decide to share personal data, they benefit from the complementarity between information and quality, but they pay personalized prices instead of a uniform price. We find that, if the complementarity is strong enough, then product quality is higher with than without the opt-in regime. Privacy regulation may have conflicting effects on consumers with different attitudes towards privacy, and an increase in quality is necessary to improve total consumer surplus. Interestingly, these results hold both under monopoly and imperfect product market competition. We thus recommend that privacy protection measures be grounded in the study of the relation between personal information and product quality

Stereotactic radiotherapy for early-stage non-small cell lung cancer

Surgical resection is treatment of choice for early stage non-small cell lung cancer, even though 20%-30% of patients do not undergo surgery. Compared to conventional fractionated radiotherapy, stereotactic body radiotherapy (SBRT) has demonstrated excellent local control (LC) and overall survival (OS). Central and ultra-central lesions present higher toxicity rates after SBRT because of their proximity to mediastinal structures. Dose escalation studies have documented that 10-12 Gy per fraction is the maximal tolerable dose with acceptable rates of treatment adverse events and survival. Peripheral lesions can be safely treated with high radiotherapy dose (biologically equivalent dose of ≥ 150 Gy) and a different SBRT dose schedule has showed comparable results with LC rates > 90% and OS comparable to surgical resection. Elderly patients, defined as 75 years or older, are a subgroup of patients who may benefit the most from SBRT, as they have higher morbidity and mortality risks because of comorbidities and decreased lung function. At present, there are no randomized studies comparing SBRT with surgery for patients who are potential candidates for surgical removal. Retrospective studies and systematic reviews have showed encouraging results in terms of cancer-specific survival and LC

Price discrimination and product quality under opt-in privacy regulation

We study how privacy regulation limiting the scope for price discrimination by a monopolist who sells online affects product quality and consumer surplus. We consider an opt-in regime where consumers may share personal data or not, in line with the recent EU GDPR. If consumers share data, they gain an additional benefit from buying related to the complementarity between information and quality, and they pay personalized prices instead of a uniform price. We find that, if the complementarity is strong enough, then product quality is higher with than without the opt-in regime. We also find that the opt-in regime has conflicting effects on consumers with different attitudes towards privacy, and that an increase in quality is a necessary condition for improving total consumer surplus. Overall, this study contributes to the debate on privacy protection by stressing the importance of analysing the relation between personal information and product quality