342 research outputs found
Characterization of soil heavy metal pools in paddy fields in Taiwan: chemical extraction and solid-solution partitioning
Ongoing industrialization has resulted in an accumulation of metals like Cd, Cu, Cr, Ni, Zn, and Pb in paddy fields across Southeast Asia. Risks of metals in soils depend on soil properties and the availability of metals in soil. At present, however, limited information is available on how to measure or predict the directly available fraction of metals in paddy soils. Here, the distribution of Cd, Cu, Cr, Ni, Zn, and Pb in 19 paddy fields among the total, reactive, and directly available pools was measured using recently developed concepts for aerated soils. Solid-solution partitioning models have been derived to predict the directly available metal pool. Such models are proven to be useful for risk assessment and to derive soil quality standards for aerated soils. Soil samples (0-25 cm) were taken from 19 paddy fields from five different communities in Taiwan in 2005 and 2006. Each field was subdivided into 60 to 108 plots resulting in a database of approximately 3,200 individual soil samples. Total (Aqua Regia (AR)), reactive (0.43 M HNO3, 0.1 M HCl, and 0.05 M EDTA), and directly available metal pools (0.01 M CaCl2) were determined. Solid-solution partitioning models were derived by multiple linear regressions using an extended Freundlich equation using the reactive metal pool, pH, and the cation exchange capacity (CEC). The influence of Zn on metal partitioning and differences between both sampling events (May/November) were evaluated. Total metals contents range from background levels to levels in excess of current soil quality standards for arable land. Between 3% (Cr) and 30% (Cd) of all samples exceed present soil quality standards based on extraction with AR. Total metal levels decreased with an increasing distance from the irrigation water inlet. The reactive metal pool relative to the total metal content is increased in the order C
Integrating Cancer Vaccines in the Standard-of-Care of Ovarian Cancer: Translating Preclinical Models to Human.
As the majority of ovarian cancer (OC) patients are diagnosed with metastatic disease, less than 40% will survive past 5 years after diagnosis. OC is characterized by a succession of remissions and recurrences. The most promising time point for immunotherapeutic interventions in OC is following debulking surgery. Accumulating evidence shows that T cells are important in OC; thus, cancer vaccines capable of eliciting antitumor T cells will be effective in OC treatment. In this review, we discuss different cancer vaccines and propose strategies for their incorporation into the OC standard-of-care regimens. Using the murine ID8 ovarian tumor model, we provide evidence that a cancer vaccine can be effectively combined with OC standard-of-care to achieve greater overall efficacy. We demonstrate several important similarities between the ID8 model and OC patients, in terms of response to immunotherapies, and the ID8 model can be an important tool for evaluating combinatorial regimens and clinical trial designs in OC. Other emerging models, including patient-derived xenograft and genetically engineered mouse models, are continuing to improve and can be useful for evaluating cancer vaccination therapies in the near future. Here, we provide a comprehensive review of the completed and current clinical trials evaluating cancer vaccines in OC
Cryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors.
Treatment of solid tumors by ablation techniques has gained momentum in the recent years due to their technical simplicity and reduced morbidity as juxtaposed to surgery. Cryoablation is one of such techniques, known for its uniqueness to destroy the tumors by freezing to lethal temperatures. Freezing the tumor locally and allowing it to remain in situ unleashes an array of tumor antigens to be exposed to the immune system, paving the way for the generation of anti-tumor immune responses. However, the immune responses triggered in most cases are insufficient to eradicate the tumors with systemic spread. Therefore, combination of cryoablation and immunotherapy is a new treatment strategy currently being evaluated for its efficacy, notably in patients with metastatic disease. This article examines the mechanistic fabric of cryoablation for the generation of an effective immune response against the tumors, and various possibilities of its combination with different immunotherapies that are capable of inducing exceptional therapeutic responses. The combinatorial treatment avenues discussed in this article if explored in sufficient profundity, could reach the pinnacle of future cancer medicine
Rate of Freeze Impacts the Survival and Immune Responses Post Cryoablation of Melanoma.
The emergence of ablative therapies has revolutionized the treatment of inoperable solid tumors. Cryoablation stands out for its uniqueness of operation based on hypothermia, and for its ability to unleash the native tumor antigens, resulting in the generation of anti-tumor immune responses. It is not clearly understood how alterations in the rate of freeze impact the immune response outcomes. In this study, we tested fast freeze and slow freeze rates for their locoregional effectiveness and their ability to elicit immune responses in a B16F10 mouse model of melanoma. Tumor bearing mice treated with fast freeze protocol survived better than the ones treated with slow freeze protocol. Fast freeze resulted in a higher magnitude of CD4 <sup>+</sup> and CD8 <sup>+</sup> T-cell responses, and a significantly extended survival post re-challenge. Thus, fast freeze rate should be applied in any future studies employing cryoablation as an in vivo vaccination tool in conjunction with targeted immunotherapies
PO-0698: Clinical outcomes of 4D CBCT-guided stereotactic body radiotherapy for inoperable hepatocellular carcinomas
Poster: Clinical track: Gastrointestinal tumours (upper and lower GI)published_or_final_version3rd ESTRO Forum, Barcelona, Spain, 24-28 April 2015. In Radiotherapy & Oncology, 2015, v. 115, p. S342-S34
Neutrino and axion hot dark matter bounds after WMAP-7
We update cosmological hot dark matter constraints on neutrinos and hadronic
axions. Our most restrictive limits use 7-year data from the Wilkinson
Microwave Anisotropy Probe for the cosmic microwave background anisotropies,
the halo power spectrum (HPS) from the 7th data release of the Sloan Digital
Sky Survey, and the Hubble constant from Hubble Space Telescope observations.
We find 95% C.L. upper limits of \sum m_\nu<0.44 eV (no axions), m_a<0.91 eV
(assuming \sum m_\nu=0), and \sum m_\nu<0.41 eV and m_a<0.72 eV for two hot
dark matter components after marginalising over the respective other mass. CMB
data alone yield \sum m_\nu<1.19 eV (no axions), while for axions the HPS is
crucial for deriving m_a constraints. This difference can be traced to the fact
that for a given hot dark matter fraction axions are much more massive than
neutrinos.Comment: 9 pages, 3 figures, uses iopart.cls; v2: one additional figure,
references added, version accepted by JCA
Cosmological parameters from large scale structure - geometric versus shape information
The matter power spectrum as derived from large scale structure (LSS) surveys
contains two important and distinct pieces of information: an overall smooth
shape and the imprint of baryon acoustic oscillations (BAO). We investigate the
separate impact of these two types of information on cosmological parameter
estimation, and show that for the simplest cosmological models, the broad-band
shape information currently contained in the SDSS DR7 halo power spectrum (HPS)
is by far superseded by geometric information derived from the baryonic
features. An immediate corollary is that contrary to popular beliefs, the upper
limit on the neutrino mass m_\nu presently derived from LSS combined with
cosmic microwave background (CMB) data does not in fact arise from the possible
small-scale power suppression due to neutrino free-streaming, if we limit the
model framework to minimal LambdaCDM+m_\nu. However, in more complicated
models, such as those extended with extra light degrees of freedom and a dark
energy equation of state parameter w differing from -1, shape information
becomes crucial for the resolution of parameter degeneracies. This conclusion
will remain true even when data from the Planck surveyor become available. In
the course of our analysis, we introduce a new dewiggling procedure that allows
us to extend consistently the use of the SDSS HPS to models with an arbitrary
sound horizon at decoupling. All the cases considered here are compatible with
the conservative 95%-bounds \sum m_\nu < 1.16 eV, N_eff = 4.8 \pm 2.0.Comment: 18 pages, 4 figures; v2: references added, matches published versio
Sterile neutrinos with eV masses in cosmology -- how disfavoured exactly?
We study cosmological models that contain sterile neutrinos with eV-range
masses as suggested by reactor and short-baseline oscillation data. We confront
these models with both precision cosmological data (probing the CMB decoupling
epoch) and light-element abundances (probing the BBN epoch). In the minimal
LambdaCDM model, such sterile neutrinos are strongly disfavoured by current
data because they contribute too much hot dark matter. However, if the
cosmological framework is extended to include also additional relativistic
degrees of freedom -- beyond the three standard neutrinos and the putative
sterile neutrinos, then the hot dark matter constraint on the sterile states is
considerably relaxed. A further improvement is achieved by allowing a dark
energy equation of state parameter w<-1. While BBN strongly disfavours extra
radiation beyond the assumed eV-mass sterile neutrino, this constraint can be
circumvented by a small nu_e degeneracy. Any model containing eV-mass sterile
neutrinos implies also strong modifications of other cosmological parameters.
Notably, the inferred cold dark matter density can shift up by 20 to 75%
relative to the standard LambdaCDM value.Comment: 14 pages, 6 figures, v2: minor changes, matches version accepted for
publication in JCA
Antimatter from the cosmological baryogenesis and the anisotropies and polarization of the CMB radiation
We discuss the hypotheses that cosmological baryon asymmetry and entropy were
produced in the early Universe by phase transition of the scalar fields in the
framework of spontaneous baryogenesis scenario. We show that annihilation of
the matter-antimatter clouds during the cosmological hydrogen recombination
could distort of the CMB anisotropies and polarization by delay of the
recombination. After recombination the annihilation of the antibaryonic clouds
(ABC) and baryonic matter can produce peak-like reionization at the high
redshifts before formation of quasars and early galaxy formation. We discuss
the constraints on the parameters of spontaneous baryogenesis scenario by the
recent WMAP CMB anisotropy and polarization data and on possible manifestation
of the antimatter clouds in the upcoming PLANCK data.Comment: PRD in press with minor change
Cosmic Microwave Background Observables of Small Field Models of Inflation
We construct a class of single small field models of inflation that can
predict, contrary to popular wisdom, an observable gravitational wave signal in
the cosmic microwave background anisotropies. The spectral index, its running,
the tensor to scalar ratio and the number of e-folds can cover all the
parameter space currently allowed by cosmological observations. A unique
feature of models in this class is their ability to predict a negative spectral
index running in accordance with recent cosmic microwave background
observations. We discuss the new class of models from an effective field theory
perspective and show that if the dimensionless trilinear coupling is small, as
required for consistency, then the observed spectral index running implies a
high scale of inflation and hence an observable gravitational wave signal. All
the models share a distinct prediction of higher power at smaller scales,
making them easy targets for detection.Comment: 13 pages, 3 figures, added numerical analysis and discussion on the
properties of the spectra. Version to be published in JCA
- …