524 research outputs found
Final report of the Construction Industry Institute, Hong Kong research project on reinventing the Hong Kong construction industry for its sustainable development
Author name used in this publication: Andrew N. BaldwinAuthor name used in this publication: Y. H. ChiangAuthor name used in this publication: Joyce W. S. CheungAuthor name used in this publication: Joanne W. S. NgConstruction Industry Institute-Hong Kong Report, no. 132008-2009 > Academic research: not refereed > Research book or monograph (author)Other Versio
Augmented Two-Channel Arrhythmia Detection: An Efficient Diagnostic Method for Implantable Devices
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75624/1/j.1540-8159.1996.tb03164.x.pd
Inside-Out Evacuation of Transitional Protoplanetary Disks by the Magneto-Rotational Instability
How do T Tauri disks accrete? The magneto-rotational instability (MRI)
supplies one means, but protoplanetary disk gas is typically too poorly ionized
to be magnetically active. Here we show that the MRI can, in fact, explain
observed accretion rates for the sub-class of T Tauri disks known as
transitional systems. Transitional disks are swept clean of dust inside rim
radii of ~10 AU. Stellar coronal X-rays ionize material in the disk rim,
activating the MRI there. Gas flows from the rim to the star, at a rate limited
by the depth to which X-rays ionize the rim wall. The wider the rim, the larger
the surface area that the rim wall exposes to X-rays, and the greater the
accretion rate. Interior to the rim, the MRI continues to transport gas; the
MRI is sustained even at the disk midplane by super-keV X-rays that Compton
scatter down from the disk surface. Accretion is therefore steady inside the
rim. Blown out by radiation pressure, dust largely fails to accrete with gas.
Contrary to what is usually assumed, ambipolar diffusion, not Ohmic
dissipation, limits how much gas is MRI-active. We infer values for the
transport parameter alpha on the order of 0.01 for GM Aur, TW Hyd, and DM Tau.
Because the MRI can only afflict a finite radial column of gas at the rim, disk
properties inside the rim are insensitive to those outside. Thus our picture
provides one robust setting for planet-disk interaction: a protoplanet interior
to the rim will interact with gas whose density, temperature, and transport
properties are definite and decoupled from uncertain initial conditions. Our
study also supplies half the answer to how disks dissipate: the inner disk
drains from the inside out by the MRI, while the outer disk photoevaporates by
stellar ultraviolet radiation.Comment: Accepted to Nature Physics June 7, 2007. The manuscript for
publication is embargoed per Nature policy. This arxiv.org version contains
more technical details and discussion, and is distributed with permission
from the editors. 10 pages, 4 figure
A local survey on skeletal related complications in patients with carcinoma of prostate having hormonal therapy
Moderated Poster (Free Paper) Session I - Prostate : Benign and Malignant: MP.1-5香港泌尿外科學會published_or_final_versionThe 17th Annual Scientific Meeting of the Hong Kong Urological Association, Hong Kong, 6 November 2011. In Program Book, 2011, p. 5
The Individual and Synergistic Indexes for Assessments of Heavy Metal Contamination in Global Rivers and Risk: a Review
This article provides an overview of heavy metal contamination in rivers and assessment methods of their contamination and effects. According to literature, rivers with heavy metal contamination in surface water are mainly found in developing countries in Asia, Africa, and Latin America and the Caribbean area, while rivers with heavy metal contamination in sediments are mostly found in Europe. The increase in heavy metal contamination in rivers has led to the adoption of individual and synergistic assessment methods. Individual methods are useful in assessing the contamination and effects for a single heavy metal, while synergistic methods assess the combined contamination and effects of several heavy metals present in surface water and sediments. These two approaches have been commonly used together in recent studies to overcome the limitations of each other and provide a more comprehensive assessment. The developments, equations, advantages, limitations, and future perspectives of these methods are discussed in this review. Calculating indexes are simple, easy-to-implement, and effective methods to provide early alerts for the environmental changes and the adverse impacts on ecosystems and human health. However, calculating indexes still have limitations due to the lack of background concentrations of heavy metals in the study area. Therefore, this issue should be addressed to overcome the limitations of these methods in the future. This review provides a useful reference for future studies on heavy metal contamination in global rivers and the assessment methods for heavy metal contamination and effects
In Vivo Depletion of Lymphotoxin-Alpha Expressing Lymphocytes Inhibits Xenogeneic Graft-versus-Host-Disease
Graft-versus-host disease (GVHD) is a major barrier to successful allogeneic hematopoietic cell transplantation and is largely mediated by activated donor lymphocytes. Lymphotoxin (LT)-α is expressed by subsets of activated T and B cells, and studies in preclinical models demonstrated that targeted depletion of these cells with a mouse anti-LT-α monoclonal antibody (mAb) was efficacious in inhibiting inflammation and autoimmune disease. Here we demonstrate that LT-α is also upregulated on activated human donor lymphocytes in a xenogeneic model of GVHD and targeted depletion of these donor cells ameliorated GVHD. A depleting humanized anti-LT-α mAb, designated MLTA3698A, was generated that specifically binds to LT-α in both the soluble and membrane-bound forms, and elicits antibody-dependent cellular cytotoxicity (ADCC) activity in vitro. Using a human peripheral blood mononuclear cell transplanted SCID (Hu-SCID) mouse model of GVHD, the anti-human LT-α mAb specifically depleted activated LT-expressing human donor T and B cells, resulting in prolonged survival of the mice. A mutation in the Fc region, rendering the mAb incapable of mediating ADCC, abolished all in vitro and in vivo effects. These data support a role for using a depleting anti-LT-α antibody in treating immune diseases such as GVHD and autoimmune diseases
A novel aromatic oil compound inhibits microbial overgrowth on feet: a case study
<p>Abstract</p> <p>Background</p> <p>Athlete's Foot (Tinea pedis) is a form of ringworm associated with highly contagious yeast-fungi colonies, although they look like bacteria. Foot bacteria overgrowth produces a harmless pungent odor, however, uncontrolled proliferation of yeast-fungi produces small vesicles, fissures, scaling, and maceration with eroded areas between the toes and the plantar surface of the foot, resulting in intense itching, blisters, and cracking. Painful microbial foot infection may prevent athletic participation. Keeping the feet clean and dry with the toenails trimmed reduces the incidence of skin disease of the feet. Wearing sandals in locker and shower rooms prevents intimate contact with the infecting organisms and alleviates most foot-sensitive infections. Enclosing feet in socks and shoes generates a moisture-rich environment that stimulates overgrowth of pungent both aerobic bacteria and infectious yeast-fungi. Suppression of microbial growth may be accomplished by exposing the feet to air to enhance evaporation to reduce moistures' growth-stimulating effect and is often neglected. There is an association between yeast-fungi overgrowths and disabling foot infections. Potent agents virtually exterminate some microbial growth, but the inevitable presence of infection under the nails predicts future infection. Topical antibiotics present a potent approach with the ideal agent being one that removes moisture producing antibacterial-antifungal activity. Severe infection may require costly prescription drugs, salves, and repeated treatment.</p> <p>Methods</p> <p>A 63-y female volunteered to enclose feet in shoes and socks for 48 hours. Aerobic bacteria and yeast-fungi counts were determined by swab sample incubation technique (1) after 48-hours feet enclosure, (2) after washing feet, and (3) after 8-hours socks-shoes exposure to a aromatic oil powder-compound consisting of <it>arrowroot, baking soda, basil oil, tea tree oil, sage oil, and clove oil</it>.</p> <p>Conclusion</p> <p>Application of this novel compound to the external surfaces of feet completely inhibited both aerobic bacteria and yeast-fungi-mold proliferation for 8-hours in spite of being in an enclosed environment compatible to microbial proliferation. Whether topical application of this compound prevents microbial infections in larger populations is not known. This calls for more research collected from subjects exposed to elements that may increase the risk of microbial-induced foot diseases.</p
A Triple Protostar System Formed via Fragmentation of a Gravitationally Unstable Disk
Binary and multiple star systems are a frequent outcome of the star formation
process, and as a result, almost half of all sun-like stars have at least one
companion star. Theoretical studies indicate that there are two main pathways
that can operate concurrently to form binary/multiple star systems: large scale
fragmentation of turbulent gas cores and filaments or smaller scale
fragmentation of a massive protostellar disk due to gravitational instability.
Observational evidence for turbulent fragmentation on scales of 1000~AU has
recently emerged. Previous evidence for disk fragmentation was limited to
inferences based on the separations of more-evolved pre-main sequence and
protostellar multiple systems. The triple protostar system L1448 IRS3B is an
ideal candidate to search for evidence of disk fragmentation. L1448 IRS3B is in
an early phase of the star formation process, likely less than 150,000 years in
age, and all protostars in the system are separated by 200~AU. Here we
report observations of dust and molecular gas emission that reveal a disk with
spiral structure surrounding the three protostars. Two protostars near the
center of the disk are separated by 61 AU, and a tertiary protostar is
coincident with a spiral arm in the outer disk at a 183 AU separation. The
inferred mass of the central pair of protostellar objects is 1 M,
while the disk surrounding the three protostars has a total mass of 0.30
M_{\sun}. The tertiary protostar itself has a minimum mass of 0.085
M. We demonstrate that the disk around L1448 IRS3B appears susceptible
to disk fragmentation at radii between 150~AU and 320~AU, overlapping with the
location of the tertiary protostar. This is consistent with models for a
protostellar disk that has recently undergone gravitational instability,
spawning one or two companion stars.Comment: Published in Nature on Oct. 27th. 24 pages, 8 figure
Dusty Planetary Systems
Extensive photometric stellar surveys show that many main sequence stars show
emission at infrared and longer wavelengths that is in excess of the stellar
photosphere; this emission is thought to arise from circumstellar dust. The
presence of dust disks is confirmed by spatially resolved imaging at infrared
to millimeter wavelengths (tracing the dust thermal emission), and at optical
to near infrared wavelengths (tracing the dust scattered light). Because the
expected lifetime of these dust particles is much shorter than the age of the
stars (>10 Myr), it is inferred that this solid material not primordial, i.e.
the remaining from the placental cloud of gas and dust where the star was born,
but instead is replenished by dust-producing planetesimals. These planetesimals
are analogous to the asteroids, comets and Kuiper Belt objects (KBOs) in our
Solar system that produce the interplanetary dust that gives rise to the
zodiacal light (tracing the inner component of the Solar system debris disk).
The presence of these "debris disks" around stars with a wide range of masses,
luminosities, and metallicities, with and without binary companions, is
evidence that planetesimal formation is a robust process that can take place
under a wide range of conditions. This chapter is divided in two parts. Part I
discusses how the study of the Solar system debris disk and the study of debris
disks around other stars can help us learn about the formation, evolution and
diversity of planetary systems by shedding light on the frequency and timing of
planetesimal formation, the location and physical properties of the
planetesimals, the presence of long-period planets, and the dynamical and
collisional evolution of the system. Part II reviews the physical processes
that affect dust particles in the gas-free environment of a debris disk and
their effect on the dust particle size and spatial distribution.Comment: 68 pages, 25 figures. To be published in "Solar and Planetary
Systems" (P. Kalas and L. French, Eds.), Volume 3 of the series "Planets,
Stars and Stellar Systems" (T.D. Oswalt, Editor-in-chief), Springer 201
Small but crucial : the novel small heat shock protein Hsp21 mediates stress adaptation and virulence in Candida albicans
Peer reviewedPublisher PD
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