Recent advances in 3D printing of biomaterials.

3D Printing promises to produce complex biomedical devices according to computer design using patient-specific anatomical data. Since its initial use as pre-surgical visualization models and tooling molds, 3D Printing has slowly evolved to create one-of-a-kind devices, implants, scaffolds for tissue engineering, diagnostic platforms, and drug delivery systems. Fueled by the recent explosion in public interest and access to affordable printers, there is renewed interest to combine stem cells with custom 3D scaffolds for personalized regenerative medicine. Before 3D Printing can be used routinely for the regeneration of complex tissues (e.g. bone, cartilage, muscles, vessels, nerves in the craniomaxillofacial complex), and complex organs with intricate 3D microarchitecture (e.g. liver, lymphoid organs), several technological limitations must be addressed. In this review, the major materials and technology advances within the last five years for each of the common 3D Printing technologies (Three Dimensional Printing, Fused Deposition Modeling, Selective Laser Sintering, Stereolithography, and 3D Plotting/Direct-Write/Bioprinting) are described. Examples are highlighted to illustrate progress of each technology in tissue engineering, and key limitations are identified to motivate future research and advance this fascinating field of advanced manufacturing

Qualitative picture of a new mechanism for high-Tc superconductors

Xu et al. observed enhanced Nernst effect and Iguchi et al. observed patched diamagnetism, both well above $T_c$ in underdoped high-$T_c$ superconductors (HTSCs). A new mechanism is proposed here, which seems to naturally explain, at least qualitatively, these observations, as well as the d-wave nature and continuity of pseudogap and pairing gap, the tunneling conductance above $T_c$, as well as $T^*(x)$, $T_{\nu}(x)$, $T_c(x)$, etc. This mechanism combines features of dynamic charged stripes, preformed pairs, and spin-bags: At appropriete doping levels, the doped holes (and perhaps also electrons) will promote the formation of anti-phase islands in short-range anti-ferromagnetic order. On the boundary of each such island reside two doped carriers; the unscreened Coulomb repulsion between them stabilizes its size. Superconductivity results when such ``pre-formed pairs'' Bose-condense.Comment: 8 pages, 4 figures, New3SC-4 Conference Proceedings, to be published in ijmp

Neutrino Masses in a 5D SU(3)WSU(3)_W TeV Unification Model

We study the generation of neutrino masses in the $SU(3)_W$ electroweak unified theory in $M_4\times S_1/(Z_2\times Z'_2)$ spacetime. By appropriate orbifolding, the bulk symmetry $SU(3)_W$ is broken into $SU(2)_L \times U(1)_Y$ at one of the fixed points, where the quarks reside. The leptons form $SU(3)_W$ triplets, localized at the other symmetric fixed point. The fermion masses arise from the bulk Higgs sector containing a triplet and an anti-sextet. We construct neutrino Majorana masses via 1-loop quantum corrections by adding a parity odd bulk triplet scalar. No right-handed neutrino is needed. The neutrino mass matrix is of the inverted hierarchy type. We show that the model can easily accommodate the bi-large mixing angle solution favored by the recent neutrino experiments without much fine tuning of parameters. The constraints from \mu\ra 3e transition and neutrinoless double beta decays are discussed.Comment: 14 pages, 4 figure

A quantitative assessment of empirical magnetic field models at geosynchronous orbit during magnetic storms

[1] We evaluate the performance of recent empirical magnetic field models (Tsyganenko, 1996, 2002a, 2002b; Tsyganenko and Sitnov, 2005, hereafter referred to as T96, T02 and TS05, respectively) during magnetic storm times including both pre- and post-storm intervals. The model outputs are compared with GOES observations of the magnetic field at geosynchronous orbit. In the case of a major magnetic storm, the T96 and T02 models predict anomalously strong negative Bz at geostationary orbit on the nightside due to input values exceeding the model limits, whereas a comprehensive magnetic field data survey using GOES does not support that prediction. On the basis of additional comparisons using 52 storm events, we discuss the strengths and limitations of each model. Furthermore, we quantify the performance of individual models at predicting geostationary magnetic fields as a function of local time, Dst, and storm phase. Compared to the earlier models (T96 and T02), the most recent storm-time model (TS05) has the best overall performance across the entire range of local times, storm levels, and storm phases at geostationary orbit. The field residuals between TS05 and GOES are small (≤3 nT) compared to the intrinsic short time-scale magnetic variability of the geostationary environment even during non-storm conditions (∼24 nT). Finally, we demonstrate how field model errors may affect radiation belt studies when estimating electron phase space density

Adenovirus-mediated gene transfer to liver grafts: An improved method to maximize infectivity

Background. Adenoviral gene therapy in liver transplantation has many potential applications, but current vector delivery methods to grafts lack efficiency and require high titers. In this study, we attempted to improve gene delivery efficacy using three different delivery methods to liver grafts with adenoviral vector encoding the LacZ marker gene (AdLacZ). Methods. AdLacZ was delivered to cold preserved rat liver grafts by: (1) continuous perfusion via the portal vein (portal perfusion), (2) continuous perfusion via both the portal vein and hepatic artery (dual perfusion), and (3) trapping viral perfusate in the liver vasculature by clamping outflow (clamp technique). Results. Using 1x109 plaque-forming units of Ad-LacZ (multiplicity of infection of 0.4), transduction rate in 3-hr preserved liver grafts, determined by 5-bromo-4-chromo-3-indolyl-β-D-galactopyranoside staining and β-galactosidase assay 48 hr after transplantation, was best with clamp technique (21.5±2.7% 5-bromo-4-chromo-3-indolyl-β-D- galactopyranoside-positive cells and 81.1±3.6 U/g β-galactosidase), followed by dual perfusion (18.5±1.8%, 66.6±19.4 U/g) and portal perfusion (8.8±2.5%, 19.7±15.4 U/g). Further studies using clamp technique demonstrated a near-maximal gene transfer rate of 30% at multiplicity of infection of 0.4 with prolonged cold ischemia to 18 hr. Transgene expression was stable for 2 weeks and slowly declined to 7.8±12.1% at day 28. Lack of inflammatory response was confirmed by histopathological examination and liver enzymes. Transduction was selectively induced in hepatocytes with nearly no extrahepatic transgene expression in the lung and spleen. Conclusions. The clamp technique provides a highly efficient viral gene delivery method to cold preserved liver grafts. This method offers maximal infectivity of adenoviral vector with minimal technical manipulation

Cellular Ability to Sense Spatial Gradients in the Presence of Multiple Competitive Ligands

Many eukaryotic and prokaryotic cells can exhibit remarkable sensing ability under small gradient of chemical compound. In this study, we approach this phenomenon by considering the contribution of multiple ligands to the chemical kinetics within Michaelis-Menten model. This work was inspired by the recent theoretical findings from Bo Hu et al. [Phys. Rev. Lett. 105, 048104 (2010)], our treatment with practical binding energies and chemical potential provides the results which are consistent with experimental observations.Comment: 5 pages, 4 figure

Numerical Method for Accessing the Universal Scaling Function for a Multi-Particle Discrete Time Asymmetric Exclusion Process

In the universality class of the one dimensional Kardar-Parisi-Zhang surface growth, Derrida and Lebowitz conjectured the universality of not only the scaling exponents, but of an entire scaling function. Since Derrida and Lebowitz's original publication [PRL 80 209 (1998)] this universality has been verified for a variety of continuous time, periodic boundary systems in the KPZ universality class. Here, we present a numerical method for directly examining the entire particle flux of the asymmetric exclusion process (ASEP), thus providing an alternative to more difficult cumulant ratios studies. Using this method, we find that the Derrida-Lebowitz scaling function (DLSF) properly characterizes the large system size limit (N-->infty) of a single particle discrete time system, even in the case of very small system sizes (N <= 22). This fact allows us to not only verify that the DLSF properly characterizes multiple particle discrete-time asymmetric exclusion processes, but also provides a way to numerically solve for quantities of interest, such as the particle hopping flux. This method can thus serve to further increase the ease and accessibility of studies involving even more challenging dynamics, such as the open boundary ASEP

Social media and orthodontics – are our patients scrolling?

OBJECTIVE: To assess patients’ awareness of the availability of information related to orthodontics on social media, and to explore patients’ willingness to engage with social media to aid with orthodontic treatment. DESIGN: Prospective cross-sectional survey. SETTING: This survey was conducted at Croydon University Hospital orthodontic department. PARTICIPANTS: A total of 125 orthodontic patients, both new and in treatment. There were no exclusion criteria. METHODS: All participants completed a questionnaire designed to explore their awareness, access to and utilisation of social media as well as their willingness to engage with social media to support orthodontic treatment. There were no age restrictions or exclusion criteria. RESULTS: Of the patients, 99% had access to social media. Of these patients, 64% were aware that social media platforms were available to help with orthodontic treatment, 30% had utilised social media related to orthodontics, with the most popular platforms being Instagram (n = 17) and Snapchat (n = 12). Of the patients, 73% stated that they would be willing to use social media in the future to support orthodontic treatment. CONCLUSION: Social media can be engaging, accessible and versatile, and has been shown to be effective at improving patients’ knowledge regarding orthodontic treatment. As such, it may be used as a valuable tool for information provision to engage orthodontic patients. Awareness of the availability of orthodontics content on social media is increasing; however, only one-third of participants had previously used it to aid with orthodontic treatment. Given the availability of information on social media targeted at orthodontic patients there is a need to assess the quality of this information and if appropriate navigate patients towards high-quality, effective resources

Heliospheric plasma sheets

[1] As a high-beta feature on scales of hours or less, the heliospheric plasma sheet (HPS) encasing the heliospheric current sheet shows a high degree of variability. A study of 52 sector boundaries identified in electron pitch angle spectrograms in Wind data from 1995 reveals that only half concur with both high-beta plasma and current sheets, as required for an HPS. The remaining half lack either a plasma sheet or current sheet or both. A complementary study of 37 high-beta events reveals that only 5 contain sector boundaries while nearly all (34) contain local magnetic field reversals, however brief. We conclude that high-beta plasma sheets surround current sheets but that most of these current sheets are associated with fields turned back on themselves. The findings are consistent with the hypothesis that high-beta plasma sheets, both at and away from sector boundaries, are the heliospheric counterparts of the small coronal transients observed at the tips of helmet streamers, in which case the proposed mechanism for their release, interchange reconnection, could be responsible for the field inversions

Probing the superconducting gap symmetry of PrRu4_{4}Sb12_{12}: A comparison with PrOs4_{4}Sb12_{12}

We report measurements of the magnetic penetration depth $\lambda$ in single crystals of PrRu$_{4}$Sb$_{12}$ down to 0.1 K. Both $\lambda$ and superfluid density $\rho_{s}$ exhibit an exponential behavior for $T$ $<$ 0.5$T_{c}$, with parameters $\Delta$(0)/\textit{k}$_{B}$\textit{T}$_{c}$ = 1.9 and $\lambda(0)$ = 2900 \AA. The value of $\Delta$(0) is consistent with the specific-heat jump value of $\Delta C/\gamma T_{c}$ = 1.87 measured elsewhere, while the value of $\lambda(0)$ is consistent with the measured value of the electronic heat-capacity coefficient $\gamma$. Our data are consistent with PrRu$_{4}$Sb$_{12}$ being a moderate-coupling, fully-gapped superconductor. We suggest experiments to study how the nature of the superconducting state evolves with increasing Ru substitution for Os