Institutional and policy issues in the management of fisheries and coastal resources in Cambodia

Fishery management, Governments, Fishery policies, Resource conservation, Resource management, Cambodia,

Geometric numerical schemes for the KdV equation

Geometric discretizations that preserve certain Hamiltonian structures at the discrete level has been proven to enhance the accuracy of numerical schemes. In particular, numerous symplectic and multi-symplectic schemes have been proposed to solve numerically the celebrated Korteweg-de Vries (KdV) equation. In this work, we show that geometrical schemes are as much robust and accurate as Fourier-type pseudo-spectral methods for computing the long-time KdV dynamics, and thus more suitable to model complex nonlinear wave phenomena.Comment: 22 pages, 14 figures, 74 references. Other author's papers can be downloaded at http://www.lama.univ-savoie.fr/~dutykh

Robust SARS-CoV-2 T cell responses with common TCR?? motifs toward COVID-19 vaccines in patients with hematological malignancy impacting B cells

Immunocompromised hematology patients are vulnerable to severe COVID-19 and respond poorly to vaccination. Relative deficits in immunity are, however, unclear, especially after 3 vaccine doses. We evaluated immune responses in hematology patients across three COVID-19 vaccination doses. Seropositivity was low after a first dose of BNT162b2 and ChAdOx1 (∼26%), increased to 59%–75% after a second dose, and increased to 85% after a third dose. While prototypical antibody-secreting cells (ASCs) and T follicular helper (Tfh) cell responses were elicited in healthy participants, hematology patients showed prolonged ASCs and skewed Tfh2/17 responses. Importantly, vaccine-induced expansions of spike-specific and peptide-HLA tetramer-specific CD4+/CD8+ T cells, together with their T cell receptor (TCR) repertoires, were robust in hematology patients, irrespective of B cell numbers, and comparable to healthy participants. Vaccinated patients with breakthrough infections developed higher antibody responses, while T cell responses were comparable to healthy groups. COVID-19 vaccination induces robust T cell immunity in hematology patients of varying diseases and treatments irrespective of B cell numbers and antibody response

Numerical simulation and optimization of the injection blow molding of polypropylene bottles - a single stage process

International audienceSingle stage injection blow molding process, without preform storage and reheat, could be run on a standard injection molding machine, with the aim of producing short series of specific hollow parts. The polypropylene bottles are blow molded right after being injected. This implies that the preform has to remain sufficiently malleable to be blown while being viscous enough to avoid being pierced during the blow molding stage. These constraints lead to a small processing window, and so the process takes place between the melting temperature and the crystallization temperature, where the polypropylene is in its molten state but cool enough to enhance its viscosity without crystallizing. This single stage process introduces temperature gradients, high stretch rate and high cooling rate. Melt rheometry tests were performed to characterize the polymer behavior in the temperature range of the process, as well as Differential Scanning Calorimetry. A viscous Cross model is used with the thermal dependence assumed by an Arrhenius law. The process is simulated through a finite element code (POLYFLOW) in the ANSYS Workbench framework. The geometry allows an axisymmetric approach. The transient simulation is run under anisothermal conditions and viscous heating is taken into account. Sensitivity studies are carried out and reveal the influence of process parameters such as the material behavior, the blowing pressure and the initial temperature field. Thickness measurements using image analysis are performed and the simulation results are compared to the experimental ones. The simulation shows broad agreements with the experimental results. An optimization loop is run to determine the optimal initial thickness repartition. Design points are defined along the preform and the optimization modifies the thickness at these locations

A high carbohydrate, but not fat or protein meal attenuates postprandial ghrelin, PYY and GLP-1 responses in Chinese men

10.1371/journal.pone.0191609PLoS ONE131e019160