Impact of edge-removal on the centrality betweenness of the best spreaders

The control of epidemic spreading is essential to avoid potential fatal consequences and also, to lessen unforeseen socio-economic impact. The need for effective control is exemplified during the severe acute respiratory syndrome (SARS) in 2003, which has inflicted near to a thousand deaths as well as bankruptcies of airlines and related businesses. In this article, we examine the efficacy of control strategies on the propagation of infectious diseases based on removing connections within real world airline network with the associated economic and social costs taken into account through defining appropriate quantitative measures. We uncover the surprising results that removing less busy connections can be far more effective in hindering the spread of the disease than removing the more popular connections. Since disconnecting the less popular routes tend to incur less socio-economic cost, our finding suggests the possibility of trading minimal reduction in connectivity of an important hub with efficiencies in epidemic control. In particular, we demonstrate the performance of various local epidemic control strategies, and show how our approach can predict their cost effectiveness through the spreading control characteristics.Comment: 11 pages, 4 figure

Finite element implementation of the generalized-lorenz gauged A-phi formulation for low-frequency circuit modeling

The A-Φ formulation with generalized Lorenz gauge is free of catastrophic breakdown at low frequencies. In the formulation, A and Φ are completely separated and Maxwell's equations are reduced into two independent equations pertinent to A and Φ, respectively. This, however, leads to more complicated equations in contrast to the traditional A-Φ formulation, which makes the numerical representation of the physical quantities challenging, especially for A. By virtue of the differential forms theory and Whitney elements, both A and Φ are appropriately represented. The condition of the resultant matrix system is wellcontrolled as frequency becomes low, even approaches to 0. The generalized-Lorenz gauged A-Φ formulation is applied to model low-frequency circuits at μm lengthscale.postprin

Scoping review exploring the impact of digital systems on processes and outcomes in the care management of acute kidney injury and progress towards establishing learning healthcare systems

Objectives: Digital systems have long been used to improve the quality and safety of care when managing acute kidney injury (AKI). The availability of digitised clinical data can also turn organisations and their networks into learning healthcare systems (LHSs) if used across all levels of health and care. This review explores the impact of digital systems i.e. on patients with AKI care, to gauge progress towards establishing LHSs and to identify existing gaps in the research. / Methods: Embase, PubMed, MEDLINE, Cochrane, Scopus and Web of Science databases were searched. Studies of real-time or near real-time digital AKI management systems which reported process and outcome measures were included. / Results: Thematic analysis of 43 studies showed that most interventions used real-time serum creatinine levels to trigger responses to enable risk prediction, early recognition of AKI or harm prevention by individual clinicians (micro level) or specialist teams (meso level). Interventions at system (macro level) were rare. There was limited evidence of change in outcomes. / Discussion: While the benefits of real-time digital clinical data at micro level for AKI management have been evident for some time, their application at meso and macro levels is emergent therefore limiting progress towards establishing LHSs. Lack of progress is due to digital maturity, system design, human factors and policy levers. / Conclusion: Future approaches need to harness the potential of interoperability, data analytical advances and include multiple stakeholder perspectives to develop effective digital LHSs in order to gain benefits across the system

A Strict Test of Stellar Evolution Models: The Absolute Dimensions of Massive Benchmark Eclipsing Binary V578 Mon

We determine the absolute dimensions of the eclipsing binary V578 Mon, a detached system of two early B-type stars (B0V + B1V, P$=$2.40848 d) in the star-forming region NGC 2244 of the Rosette Nebula. From the light curve analysis of 40 yr of photometry and the analysis of HERMES spectra, we find radii of $5.41\pm0.04$ Rsun and $4.29\pm 0.05$ Rsun, and temperatures of $30000\pm 500$~K and $25750\pm 435$ K respectively. We find that our disentangled component spectra for V578 Mon agree well previous spectral disentangling from the literature. We also reconfirm the previous spectroscopic orbit of V578 Mon finding that masses of $14.54\pm 0.08$ Msun and $10.29\pm 0.06$ Msun are fully compatible with the new analysis. We compare the absolute dimensions to the rotating models of the Geneva and Utrecht groups and the models of Granada group. We find all three sets of models marginally reproduce the absolute dimensions of both stars with a common age within uncertainty for gravity-effective temperature isochrones. However - there are some apparent age discrepancies for the corresponding mass-radius isochrones. Models with larger convective overshoot $>0.35$ worked best. Combined with our previously determined apsidal motion of $0.07089^{+0.00021}_{-0.00013}$ deg cycle$^{-1}$, we compute the internal structure constants (tidal Love number) for the newtonian and general relativistic contribution to the apsidal motion, $\log{k_2}=-1.975\pm0.017$ and $\log{k_2}=-3.412\pm0.018$ respectively. We find the relativistic contribution to the apsidal motion of be small $<4\%$. We find that the prediction of $\log{k_{\rm 2,theo}}=-2.005\pm0.025$ of the Granada models fully agrees with our observed $\log{k_2}$.Comment: accepted for publication in AJ 05/02/201

Corporate Brand Image: Antecedents, Mediating Role and Impact on Stakeholder Expectations

Corporate identity and image are shaped by the entirety of perceptions of a variety of stakeholders, both existing and potential ones, such as customers, suppliers, employees, general public, opinion makers, and government officials. Our study is an empirical investigation of corporate brand image and impact on one such stakeholder group made up of prospective employees. A large multinational, a technical and scientific research firm, a major recruiter of graduates from campuses of reputable universities across the nation was chosen as the subject. This paper develops and tests a path model of the antecedent factors affecting corporate brand image and specific expectations that stakeholders may have of a corporate brand. Based on a thorough literature review, a corporate brand image model that treated as antecedents the four constructs, awareness of organisation’s products, perceptions about culture, personality of the focal firm, and general expectations was proposed. Specific expectations that respondents may have about working with the firm was modeled to be influenced by the corporate brand image of the firm surveyed and also by the mentioned four antecedent constructs. The model is fitted to empirical data obtained from a national sample of 368 respondents using LISREL 8.5 methodology, and strong support was found for five, partial support for two of the nine hypotheses tested. Substantial evidence can be seen for the mediating role of corporate brand image in shaping specific expectations that stakeholders have from the corporate brand. Practical significance and managerial implications for marketing investments and organisational performance are detailed.

Evaluation of the efficacy and safety of high dose short duration enrofloxacin treatment regimen for uncomplicated urinary tract infections in dogs.

BackgroundUncomplicated urinary tract infections (UTI) in dogs usually are treated with antimicrobial drugs for 10-14 days. Shorter duration antimicrobial regimens have been evaluated in human patients.HypothesisA high dose short duration (HDSD) enrofloxacin protocol administered to dogs with uncomplicated UTI will not be inferior to a 14-day treatment regimen with amoxicillin-clavulanic acid.AnimalsClient-owned adult, otherwise healthy dogs with aerobic bacterial urine culture yielding ≥ 10(3) CFU/mL of bacteria after cystocentesis.MethodsProspective, multicenter, controlled, randomized blinded clinical trial. Enrolled dogs were randomized to group 1 (enrofloxacin 18-20 mg/kg PO q24h for 3 days) or group 2 (amoxicillin-clavulanic acid 13.75-25 mg/kg PO q12h for 14 days). Urine cultures were obtained at days 0, 10, and 21. Microbiologic and clinical cure rates were evaluated 7 days after antimicrobial treatment was discontinued. Lower urinary tract signs and adverse events also were recorded.ResultsThere were 35 dogs in group 1 and 33 in group 2. The microbiologic cure rate was 77.1 and 81.2% for groups 1 and 2, respectively. The clinical cure rate was 88.6 and 87.9% for groups 1 and 2, respectively. Cure rates between groups did not differ according to the selected margin of noninferiority.Conclusions and clinical importanceHDSD enrofloxacin treatment was not inferior to a conventional amoxicillin-clavulanic acid protocol for the treatment of uncomplicated bacterial UTI in dogs. Further research is warranted to determine if this protocol will positively impact owner compliance and decrease the emergence of antimicrobial resistance