A simplified model of the source channel of the Leksell Gamma Knife(R)^(R): testing multisource configurations with PENELOPE

A simplification of the source channel geometry of the Leksell Gamma Knife$^{\circledR}$, recently proposed by the authors and checked for a single source configuration (Al-Dweri et al 2004), has been used to calculate the dose distributions along the $x$, $y$ and $z$ axes in a water phantom with a diameter of 160~mm, for different configurations of the Gamma Knife including 201, 150 and 102 unplugged sources. The code PENELOPE (v. 2001) has been used to perform the Monte Carlo simulations. In addition, the output factors for the 14, 8 and 4~mm helmets have been calculated. The results found for the dose profiles show a qualitatively good agreement with previous ones obtained with EGS4 and PENELOPE (v. 2000) codes and with the predictions of GammaPlan$^{\circledR}$. The output factors obtained with our model agree within the statistical uncertainties with those calculated with the same Monte Carlo codes and with those measured with different techniques. Owing to the accuracy of the results obtained and to the reduction in the computational time with respect to full geometry simulations (larger than a factor 15), this simplified model opens the possibility to use Monte Carlo tools for planning purposes in the Gamma Knife$^{\circledR}$.Comment: 13 pages, 8 figures, 5 table

Validation of the English and Chinese versions of the Quick-FLIC quality of life questionnaire.

A useful measure of quality of life should be easy and quick to complete. Recently, we reported the development and validation of a shortened Chinese version of the Functional Living Index-Cancer (FLIC), which we called the Quick-FLIC. In the present study of 327 English-speaking and 221 Chinese-speaking cancer patients, we validated the English version of the Quick-FLIC and further assessed the Chinese version. The 11 Quick-FLIC items were administered alongside the 11 remaining items of the full FLIC, but there appeared to be little context effect. Validity of the English version of the Quick-FLIC was attested by its strong correlation with two other measures of quality of life, and its ability to detect differences between patients with different performance status and treatment status (each P<0.001). Its internal consistency (alpha=0.86) and test-retest reliability (intraclass correlation=0.76) were also satisfactory. The measure was responsive to changes in performance status (P<0.001). The Chinese version showed similar characteristics. The Quick-FLIC behaved in ways that are highly comparable with the FLIC, even though the Quick-FLIC comprised only 11 items whereas the FLIC comprised 22. Further research is required to see whether the use of shorter instruments can improve data quality and response rates, but the fact that shorter instruments place less burden on the patients is itself inherently important

Extreme Blazars Studied with Fermi-LAT and Suzaku: 1ES 0347-121 and Blazar Candidate HESS J1943+213

We report on our study of high-energy properties of two peculiar TeV emitters: the "extreme blazar" 1ES 0347-121 and the "extreme blazar candidate" HESS J1943+213 located near the Galactic Plane. Both objects are characterized by quiescent synchrotron emission with flat spectra extending up to the hard X-ray range, and both were reported to be missing GeV counterparts in the Fermi-LAT 2-year Source Catalog. We analyze a 4.5 year accumulation of the Fermi-LAT data, resulting in the detection of 1ES 0347-121 in the GeV band, as well as in improved upper limits for HESS J1943+213. We also present the analysis results of newly acquired Suzaku data for HESS J1943+213. The X-ray spectrum is well represented by a single power law extending up to 25 keV with photon index 2.00+/-0.02 and a moderate absorption in excess of the Galactic value, in agreement with previous X-ray observations. No short-term X-ray variability was found over the 80 ks duration of the Suzaku exposure. Under the blazar hypothesis, we modeled the spectral energy distributions of 1ES 0347-121 and HESS J1943+213, and derived constraints on the intergalactic magnetic field strength and source energetics. We conclude that although the classification of HESS J1943+213 has not yet been determined, the blazar hypothesis remains the most plausible option, since in particular the broad-band spectra of the two analyzed sources along with the source model parameters closely resemble each other, and the newly available WISE and UKIDSS data for HESS J1943+213 are consistent with the presence of an elliptical host at the distance of approximately ~600 Mpc.Comment: 10 pages, 7 figures, 3 tables. Accepted by Ap

The 25 October 2010 Mentawai tsunami earthquake (M_w 7.8) and the tsunami hazard presented by shallow megathrust ruptures

The 25 October 2010 Mentawai, Indonesia earthquake (M_w 7.8) ruptured the shallow portion of the subduction zone seaward of the Mentawai islands, off-shore of Sumatra, generating 3 to 9 m tsunami run-up along southwestern coasts of the Pagai Islands that took at least 431 lives. Analyses of teleseismic P, SH and Rayleigh waves for finite-fault source rupture characteristics indicate ∼90 s rupture duration with a low rupture velocity of ∼1.5 km/s on the 10° dipping megathrust, with total slip of 2–4 m over an ∼100 km long source region. The seismic moment-scaled energy release is 1.4 × 10^(−6), lower than 2.4 × 10^(−6) found for the 17 July 2006 Java tsunami earthquake (M_w 7.8). The Mentawai event ruptured up-dip of the slip region of the 12 September 2007 Kepulauan earthquake (M_w 7.9), and together with the 4 January 1907 (M 7.6) tsunami earthquake located seaward of Simeulue Island to the northwest along the arc, demonstrates the significant tsunami generation potential for shallow megathrust ruptures in regions up-dip of great underthrusting events in Indonesia and elsewhere