Spin-echo BOLD temporal dynamics in the rat superior colliculus and lateral geniculate nucleus

Session - fMRI Neuroscience Methods & Applications I: Computer 57 (Wednesday)INTRODUCTION: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical components of the visual system[1]. The majority of fMRI studies to date focus on higher visual processing centers in the cortex. fMRI studies in rats have examined visual responses in the subcortex using long stimulus duration block-design paradigms[2-4]. These studies focused on locating responsive regions and measuring differences in BOLD responses for different stimulation frequencies. Relatively little attention has been given to BOLD temporal dynamics in the rat subcortex. In this study, we apply …published_or_final_versionThe 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montreal, QC., 7-13 May 2011.In Proceedings of the 19th ISMRM, 2011, v. 19, p. 365

BOLD fMRI study of the rat superior colliculus responding to a moving visual stimulus

Session - Animal fMRI: Computer 59 (Tuesday)INTRODUCTION: The superior colliculus (SC), or tectum, is a midbrain structure in vertebrates critical for directing eye movements[1]. It possesses neurons that are highly sensitive to moving stimuli[2]. To date, functional imaging has only been used to study the SC’s response to a stimulus moving at one speed[3]. Few fMRI studies have been conducted on the human SC because of technical challenges[4-5]. The rat SC occupies a significantly larger portion of the brain and receives a greater fraction of retinal projections. Thus, the rat is more suitable for studying SC function. In this study, we apply …published_or_final_versionThe 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montreal, QC., 7-13 May 2011. In Proceedings of the 19th ISMRM, 2011, v. 19, p. 367

Human papillomavirus status in southern Chinese women

1. The overall and type-specific human papillomavirus (HPV) prevalence differed between Hong Kong and Guangzhou healthy women. The prevalence of HPV was significantly higher in Guangzhou than Hong Kong women. Younger women had significantly higher risk of HPV infection. 2. HPV16 remained the most common type detected in both regions; the frequency increased with increasing disease severity. The prevalence of HPV58 and HPV52 was relatively high in women with normal cervix and precancerous lesions.published_or_final_versio

Accuracy versus precision in boosted top tagging with the ATLAS detector

Abstract The identification of top quark decays where the top quark has a large momentum transverse to the beam axis, known as top tagging, is a crucial component in many measurements of Standard Model processes and searches for beyond the Standard Model physics at the Large Hadron Collider. Machine learning techniques have improved the performance of top tagging algorithms, but the size of the systematic uncertainties for all proposed algorithms has not been systematically studied. This paper presents the performance of several machine learning based top tagging algorithms on a dataset constructed from simulated proton-proton collision events measured with the ATLAS detector at √ s = 13 TeV. The systematic uncertainties associated with these algorithms are estimated through an approximate procedure that is not meant to be used in a physics analysis, but is appropriate for the level of precision required for this study. The most performant algorithms are found to have the largest uncertainties, motivating the development of methods to reduce these uncertainties without compromising performance. To enable such efforts in the wider scientific community, the datasets used in this paper are made publicly available.</jats:p

Spin-Echo BOLD Temporal Dynamics in the Rat Superior Colliculus and Lateral Geniculate Nucleus

Session - fMRI Neuroscience Methods & Applications I: Computer 57 (Wednesday)INTRODUCTION: The superior colliculus (SC) and lateral geniculate nucleus (LGN) are important subcortical components of the visual system[1]. The majority of fMRI studies to date focus on higher visual processing centers in the cortex. fMRI studies in rats have examined visual responses in the subcortex using long stimulus duration block-design paradigms[2-4]. These studies focused on locating responsive regions and measuring differences in BOLD responses for different stimulation frequencies. Relatively little attention has been given to BOLD temporal dynamics in the rat subcortex. In this study, we apply …published_or_final_versionThe 19th Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2011), Montreal, QC., 7-13 May 2011.In Proceedings of the 19th ISMRM, 2011, v. 19, p. 365

Human papillomavirus infection in Southern Chinese women: a population-based study

Poster Session 36 - Inflammatory and Hormonal Factors in Relation to Cancer: abstract no. 5732Cervical cancer is a leading cause of death in women worldwide. Persistent infection of high-risk (HR) type human papillomavirus (HPV) is recognized as a necessary cause of cervical cancer. Additionally, the presence of certain predisposing factors in combination of HPV infection will significantly increase the risk of developing cervical cancer. Previous epidemiological studies showed different HPV genotype prevalence between different geographic regions. The objectives of the present study were to study and compare the prevalence and the spectrum of HPV infection in healthy women living in Hong Kong (HK) and Guangdong (GD) regions of China and the association between the potential risk factors and HPV infection. This was a cross-sectional study, and 1526 and 1300 healthy women were recruited from HK and GD, respectively. The overall and type-specific HPV prevalence were studied and compared between the two regions. The results showed that healthy women in GD with normal or abnormal cytology had significantly higher HPV prevalence (10% or 54.5%) than those in HK (6.2% or 33%, p≤0.001). The patterns of age-specific HPV prevalence were also different between the two regions. In HK, the highest HPV prevalence was in the youngest (20-30 years) and the eldest (60 and above) age groups, whereas the highest HPV prevalence in GD was observed in the youngest age group (20-30) and declined as the age increased. HPV16 and HPV52 were the most common high-risk type found in HK and GD, respectively. In HK, younger women had significantly higher risk of HPV infection, whereas lifetime number of sexual partner was strongly associated with the risk of HPV infection in GD. Lack of previous cervical screening, current smoker and having previous sexual transmitted diseases had increased risk of HPV infection for women in both regions. In summary, the overall and type-specific HPV prevalence were found different in healthy women between HK and GD. Together with the understanding of the association between the potential risk factors and HPV infection will be essential for the implementation of effective public health program for prevention of cervical cancer in Southern Chinese women.The 101st Annual Meeting of the American Association for Cancer Research (AACR), Washington, DC., 17-21 April 2010. In AACR Meeting Abstracts, 201