525 research outputs found

    Atlas Men’s Well-being Programme: Evaluation Report Atlas 2.0

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    Background to the evaluation Men’s suicide rates remain an issue of concern in the United Kingdom (UK). In England and Wales, males accounted for around three-quarters of suicide deaths registered in 2019 (4,303 male deaths compared with 1,388 female deaths). Men do not always utilise health services and may be reluctant to access help from professional mental health services, thus indicating a need to better understand men’s distress, as well as services that enable men to cope better. The Atlas men’s well-being programme was created with the intention of addressing distress, and to improve access to mental health services for men. Atlas, originated by Professor Damien Ridge and co-designed with Professor David Peters, was designed to be ‘male sensitive’ and provide counselling and/or acupuncture to men suffering from stress or distress. Atlas is based at the Victoria Medical Centre (VMC), a busy NHS GP practice in Central London with over 18,000 patients on their books. Atlas was first piloted from March 2014 until July 2014 for practice patients. An evaluation study of the original Atlas Men’s wellbeing pilot programme showed improvements in patient’s mental and physical health (Cheshire, Peters, & Ridge, 2016), with high acceptability for both men who attended as well as VMC staff. Atlas 2.0, a continuation of the pilot service based at the VMC, ran from September 2017 to the present day. The current report is an evaluation of data for this service up until January 2020

    Hydrogen atom in phase space: The Wigner representation

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    We have found an effective method of calculating the Wigner function, being a quantum analogue of joint probability distribution of position and momentum, for bound states of nonrelativistic hydrogen atom. The formal similarity between the eigenfunctions of nonrelativistic hydrogen atom in the momentum representation and Klein-Gordon propagators has allowed the calculation of the Wigner function for an arbitrary bound state of the hydrogen atom. These Wigner functions for some low lying states are depicted and discussed.Comment: 8 pages (including figures

    Evaluating the effects of planning policies on the retail sector: or do town centre first policies deliver the goods

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    Acknowledgements This paper represents work in progress and is still a preliminary draft. We would like to acknowledge the funding provided to SERC by ESRC, DCLG, BIS and the Welsh Assembly. We have benefited greatly from discussions with many colleagues and professional contacts: we would particularly like to mentio

    Spinal Cord Infarction with Multiple Etiologic Factors

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    Spinal cord infarction is uncommon and usually presents with sudden onset of paralysis and sensory disturbances. A variety of causes are described, but rarely with multiple factors involved. We report a case of a 63-year-old man with a history of diabetes mellitus, hypertension, and osteoarthritis who presented with acute onset of chest pain, numbness, and weakness associated with episodic hypotension. He had incomplete tetraplegia and was areflexic without spasticity. Pain and temperature sensations were impaired below the C7 dermatome and absent below the T4 dermatome bilaterally. Proprioception and vibration sensations were diminished on the right below the C6 dermatome. Magnetic resonance imaging showed spinal cord infarction affecting C6–T3 segments, and severe cervical and lumbar spine degenerative changes. This case illustrates an unusual presenting symptom of spinal infarction, the need to identify multiple risk factors for spinal cord infarction, and the importance of optimal preventive therapy in patients at risk

    The Family Name as Socio-Cultural Feature and Genetic Metaphor: From Concepts to Methods

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    A recent workshop entitled The Family Name as Socio-Cultural Feature and Genetic Metaphor: From Concepts to Methods was held in Paris in December 2010, sponsored by the French National Centre for Scientific Research (CNRS) and by the journal Human Biology. This workshop was intended to foster a debate on questions related to the family names and to compare different multidisciplinary approaches involving geneticists, historians, geographers, sociologists and social anthropologists. This collective paper presents a collection of selected communications

    Identification of a Locus on the X Chromosome Linked to Familial Membranous Nephropathy

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    INTRODUCTION: Membranous nephropathy (MN) is the most common cause of nephrotic syndrome (NS) in adults and is a leading cause of end-stage renal disease due to glomerulonephritis. Primary MN has a strong male predominance, accounting for approximately 65% of cases; yet, currently associated genetic loci are all located on autosomes. Previous reports of familial MN have suggested the existence of a potential X-linked susceptibility locus. Identification of such risk locus may provide clues to the etiology of MN. METHODS: We identified 3 families with 8 members affected by primary MN. Genotyping was performed using single-nucleotide polymorphism microarrays, and serum was sent for anti-phospholipase A2 receptor (PLA2R) antibody testing. All affected members were male and connected through the maternal line, consistent with X-linked inheritance. Genome-wide multipoint parametric linkage analysis using a model of X-linked recessive inheritance was conducted, and genetic risk scores (GRSs) based on known MN-associated variants were determined. RESULTS: Anti-PLA2R testing was negative in all affected family members. Linkage analysis revealed a significant logarithm of the odds score (3.260) on the short arm of the X chromosome at a locus of approximately 11 megabases (Mb). Haplotype reconstruction further uncovered a shared haplotype spanning 2 Mb present in all affected individuals from the 3 families. GRSs in familial MN were significantly lower than in anti-PLA2R–associated MN and were not different from controls. CONCLUSIONS: Our study identifies linkage of familial membranous nephropathy to chromosome Xp11.3-11.22. Family members affected with MN have a significantly lower GRS than individuals with anti-PLA2R–associated MN, suggesting that X-linked familial MN represents a separate etiologic entity

    Feeding spectra and activity of the freshwater crab Trichodactylus kensleyi (Decapoda: Brachyura: Trichodactylidae) at La Plata basin

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    Background: In inland water systems, it is important to characterize the trophic links in order to identify the ‘trophic species’ and, from the studies of functional diversity, understand the dynamics of matter and energy in these environments. The aim of this study is to analyze the natural diet of Trichodactylus kensleyi of subtropical rainforest streams and corroborate the temporal variation in the trophic activity during day hours. Results: A total of 15 major taxonomic groups were recognized in gut contents. The index of relative importance identified the following main prey items in decreasing order of importance: vegetal remains, oligochaetes, chironomid larvae, and algae. A significant difference was found in the amount of full stomachs during day hours showing a less trophic activity at midday and afternoon. The index of relative importance values evidenced the consumption of different prey according to day moments. Results of the gut content indicate that T. kensleyi is an omnivorous crab like other trichodactylid species. Opportunistic behavior is revealed by the ingestion of organisms abundant in streams such as oligochaetes and chironomid larvae. The consumption of allochthonous plant debris shows the importance of this crab as shredder in subtropical streams. However, the effective assimilation of plant matter is yet unknown in trichodactylid crabs. Conclusions: This research provides knowledge that complements previous studies about trophic relationships of trichodactylid crabs and supported the importance of T. kensleyi in the transference of energy and matter from benthic community and riparian sources to superior trophic levels using both macro- and microfauna.Fil: Williner, Verónica. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina. Universidad Nacional del Litoral. Facultad de Humanidades y Ciencias; ArgentinaFil: de Azevedo Carvalho, Debora. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; ArgentinaFil: Collins, Pablo Agustin. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto Nacional de Limnología. Universidad Nacional del Litoral. Instituto Nacional de Limnología; Argentina. Universidad Nacional del Litoral. Facultad de Bioquímica y Ciencias Biológicas; Argentin
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