Development of a longitudinal data base for tracking and analysis of attrition data

This study examined factors related to student persistence in college, with particular attention to engineering students. All direct from high school and transfer students who entered a large midwestern university in the engineering college were tracked through fourteen semesters and summer sessions between fall 1990 and spring 1995. The study was conducted for the following goals and purposes: (1) To assemble and design a data base that would allow for the characterization and tracking of all undergraduate engineering students. (2) To examine the relationships between significant variables in a model that could identify students potentially at risk of attrition. (3) To provide baseline retention data that could be compared to data from other cohort years and after retention initiatives are implemented;In order to accomplish these objectives it was necessary to obtain and reformat a very large data base. A dependent variable called category of risk was established to classify students according to their progress toward the goal of completing their engineering degrees;Statistical analyses were performed to provide college-wide, descriptive information. Methodologies were developed to predict which students were likely to be lost due to attrition. It was believed that if students who were at higher risk for attrition could be identified early in their college careers, appropriate interventions could be developed to reduce the likelihood of attrition;The approach taken in this study was supported by the information found in the review of the literature. The articles reinforced the necessity for individual colleges or institutions to monitor, analyze, and to the greatest extent possible predict student retention. The study will add to the current body of knowledge about retention and contribute to the spectrum of ideas that feed into the various theories of retention. It could also serve as a model for other universities interested in developing similar data bases or descriptive, predictive, or comparative measures. The statistical methods used in this research could be adapted to other sets of independent and dependent variables

Success rates of re-excision after positive margins for invasive lobular carcinoma of the breast.

Rates of positive margins after surgical resection of invasive lobular carcinoma (ILC) are high (ranging from 18 to 60%), yet the efficacy of re-excision lumpReceptor subtypeectomy for clearing positive margins is unknown. Concerns about the diffuse nature of ILC may drive increased rates of completion mastectomy to treat positive margins, thus lowering breast conservation rates. We therefore determined the success rate of re-excision lumpectomy in women with ILC and positive margins after surgical resection. We identified 314 cases of stage I-III ILC treated with breast conserving surgery (BCS) at the University of California, San Francisco. Surgical procedures, pathology reports, and outcomes were analyzed using univariate and multivariate statistics and Cox-proportional hazards models. We evaluated outcomes before and after the year 2014, when new margin management consensus guidelines were published. Positive initial margins occurred in 118 (37.6%) cases. Of these, 62 (52.5%) underwent re-excision lumpectomy, which cleared the margin in 74.2%. On multivariate analysis, node negativity was significantly associated with successful re-excision (odds ratio [OR] 3.99, 95% CI 1.15-13.81, p = 0.029). After 2014, we saw fewer initial positive margins (42.7% versus 25.5%, p = 0.009), second surgeries (54.6% versus 20.2%, p < 0.001), and completion mastectomies (27.7% versus 4.5%, p < 0.001). In this large cohort of women with ILC, re-excision lumpectomy was highly successful at clearing positive margins. Additionally, positive margins and completion mastectomy rates significantly decreased over time. These findings highlight improvements in management of ILC, and suggest that completion mastectomy may not be required for those with positive margins after initial BCS

Pengaruh Implementasi Event Dalam Meningkatkan Brand Awareness Pada Divisi Marketing Di PT. Honoris Industry (HORI)

PT. Honoris Industry merupakan perusahaan yang bergerak pada industry lampu LED. Perusahaan ini melihat bahwa peluang lampu LED di Indonesia sangat baik dan berpotensi tinggi. Perusahaan ini merupakan produsen lampu LED lokal yang membuat produknya sendiri yang menjadi kelebihan dari produknya. Selain itu, PT. Honoris Industry atau HORI memiliki banyak jenis lampu LED yang memiliki banyak manfaat dalam berbagai sektor industri bisnis, sehingga banyak bidang dapat merasakan dampaknya terlebih sektor rumah tangga. PT. Honoris Industry berharap dapat memberikan kontribusi kepada masyarakat lewat produk LED, mengingat setiap orang membutuhkan lampu untuk digunakan. Oleh karenanya, HORI berharap konsumen dapat memiliki brand awareness akan produk lampu LED, lewat Implementasi Event, dan Digital Marketing yang dilakukan Marketing HORI dalam meningkatkan kesadaran Brand Awareness lampu LED di pasar dan unggul dari kompetitornya sehingga menjadi terdepan, pilihan masyarakat

Analisa Faktor-Faktor yang Mempengaruhi User Satisfaction serta Implikasinya terhadap Net Benefit pada Zenius Education

Technological developments especially the internet provides advantages over the advancement of innovation in education. Technological in education is increasingly in demand because it is easier and saves time. Technological developments especially in education can be an alternative way to improve the quality of learning, knowledge, and improve achievement. With digitalization growing and many people are already using technology and the internet has encouraged peoples to use e-learning. Tutor also began to follow the existing changes from the conventional to online tutoring. However, many people who are interested in using online tutoring do not guarantee that these tutors are more successful than competitors who begin to appear in the markets with owns advantages. in this case, Zenius Education is a pioneer of EdTech in Indonesia of online tutoring has also experienced it. In fact even being the first Zenius has not become the first rank in Indonesia. Therefore, one way that Zenius can do is to increase the net profit of its service users to keep using Zenius and attract new users using Zenius to see the number of people using it. Therefore, researchers want to find out whether the system quality, information system, service quality, perceived usefulness, and user satisfaction have and influence on the net benefit of Zenius Education users. The study uses a quantitative method using online questionnaires for respondents through Google fors. The sample in this study proves 152 respondents with criteria for women and man, 14-17 years old, who are currently in high school grade 1 or grade 2, domiciled in Tangerang and use Zenius Education for a minimum of 3-6 months. Data processing was performed using Structural Equation Modeling (SEM) techniques using Lisrel 8.80 software. The results of this study indicate a positive relationship between system quality and user satisfaction, information quality with user satisfaction, service quality with user satisfaction, perceived usefulness with user satisfaction, and user satisfaction with net benefit. Therefore, Zenius can increase net benefits through user satisfaction. Zenius can accelerate the process of accessing pages on the web, adding questions and excercises in the application, adding live learning features, and two-way communication so that students can be more facilitated in the learning process because they can ask scholl material directly and get answers through the teacher robot or teacher directly. Zenius can change the appearance of the web and applications more attractive by adding colors and images and reducing information on the web to be shorther, clearer, and denser. Zenius can add report features to give students an evaluation of the lessons that are poorly understood and provide pop-up features of material that are poorly understood in order to increase knowledge and grades better

The Relationship Between Proactive Personality And Career Success In Hospitality Industry

This study is aimed at finding the relationship between the proactive personality and career success (objective career success and subjective career success) in hospitality industry. This research was done by using quantitative method where the data were collected by using questionnaires as the instrument. The data was collected from 45 samples from hospitality industry in Kuching, Sarawak. The data were then analysed by using both descriptive and inferential statistics. Besides, Pearson Correlation test procedure was used to measure the relationships between the independent variables and dependent variables. The findings have shown that there is a significant relationship between the proactive personality and career success. As such, the researcher has recommended a focus on the study that may guide the organizations and future researches

Targeting tauopathy with engineered tau-degrading intrabodies

BACKGROUND: The accumulation of pathological tau is the main component of neurofibrillary tangles and other tau aggregates in several neurodegenerative diseases, referred to as tauopathies. Recently, immunotherapeutic approaches targeting tau have been demonstrated to be beneficial in decreasing tauopathy in animal models. We previously found that passive immunotherapy with anti-tau antibody to human tau or expression of an anti-tau secreted single-chain variable fragment (scFv) in the central nervous system of a mouse model of tauopathy decreased but did not remove all tau-associated pathology. Although these and other studies demonstrate that conventional immunotherapeutic approaches targeting tau can influence tau pathogenesis, the majority of pathological tau remains in the cytosol of cells, not typically accessible to an extracellular antibody. Therefore, we reasoned targeting intracellular tau might be more efficacious in preventing or decreasing tauopathy. METHODS: By utilizing our anti-tau scFv, we generated anti-tau intrabodies for the expression in the cytosol of neurons. To enhance the degradation capacity of conventional intrabodies, we engineered chimeric anti-tau intrabodies fused to ubiquitin harboring distinct mutations that shuttle intracellular tau for either the proteasome or lysosomal mediated degradation. To evaluate the efficacy in delaying or eliminating tauopathy, we expressed our tau degrading intrabodies or controls in human tau transgenic mice by adeno-associated virus prior to overt tau pathology and after tau deposition. RESULTS: Our results demonstrate, the expression of chimeric anti-tau intrabodies significantly reduce tau protein levels in primary neuronal cultures expression human tau relative to a non-modified anti-tau intrabody. We found the expression of engineered tau-degrading intrabodies destined for proteasomal-mediated degradation are more effective in delaying or eliminating tauopathy than a conventional intrabody in aged human tau transgenic mice. CONCLUSION: This study, harnesses the strength of intrabodies that are amendable for targeting specific domains or modifications with the cell-intrinsic mechanisms that regulate protein degradation providing a new immunotherapeutic approach with potentially improved efficacy

THE INFLUENCE OF NEW WAYS OF WORKING (NWOW) ON WORK ENGAGEMENT WITH PROACTIVE PERSONALITY AND JOB CRAFTING AS MEDIATORS

Employees’ work engagement is one of the important outcomes to identify whether the employees are enjoying their work. Currently, New Ways of Working (NWOW) are increasingly being adopted in the workplace to suit the needs of a diverse workforce, with the aim of increasing work engagement. NWOW research is currently scarce, particularly in terms of the effects on people's work engagement and organisational performance. This paper contributes to an initial framework to examine the relationships of NWOW and work engagement, with proactive personality and job crafting as mediators. Identifying this relationship has the potential to contribute to work engagement and NWOW literature, and to human resource development practice

Clinical Study Socioeconomic Factors Affect Disparities in Access to Liver Transplant for Hepatocellular Cancer

Objective. The incidence/death rate of hepatocellular cancer (HCC) is increasing in America, and it is unclear if access to care contributes to this increase. Design/Patients. 575 HCC cases were reviewed for demographics, education, and tumor size. Main Outcome Measures. Endpoints to determine access to HCC care included whether an eligible patient underwent liver transplantation. Results. Transplant patients versus those not transplanted were younger (55.7 versus 61.8 yrs, P < 0.001), males (89.3% versus 74.4%, P = 0.013), and having completed high school (10.1% versus 1.2%, P = 0.016). There were differences in transplant by ethnicity, insurance, and occupation. Transplant patients with HCC had higher median income via census classification ($54,383 versus$49,383, P = 0.046) and self-reported income ($48,948 versus$38,800, P = 0.002). Differences in access may be related to exclusion criteria for liver transplant, as Pacific Islanders were more likely to have tumor size larger than 5 cm compared to Whites and have BMI > 35 (20.7%) compared to Whites (6.4%) and Asians (4.7%). Conclusions. Ethnic differences in access to transplant are associated with socioeconomic status and factors that can disqualify patients (advanced disease/morbid obesity). Efforts to overcome educational barriers and screening for HCC could improve access to transplant

Valorización de la Corporación Lindley S.A.

Para la valorización de la empresa se ha usado el método de Flujo de caja descontado, estimando los flujos de caja libres de los años 2018 al 2027 donde se considera una tasa de disminución de las ventas para el 2018 de -4,57 % y para los siguientes 9 años crecería entre 5,29 % a 4,96 %, la tasa de crecimiento perpetuo de 2,5 % y un Costo promedio de capital ponderado de 7,1 % obteniendo el valor de la empresa de S/ 6.195 millones de soles al cierre de diciembre 2017. Bajo estos parámetros y con una prima de control de 30%, el valor intrínseco de la acción común sería S/ 7.38 y el de la acción de inversión S/ 5.68. Como principales inputs de valor hemos considerado la información de la empresa en su plan estratégico a largo plazo y la información histórica de sus Estados Financieros al 31 de diciembre de 2017. Finalmente comparamos los resultados obtenidos con el precio pagado en setiembre de 2018 por Arca Continental para adquirir 223,7 millones de acciones comunes a US$ 2,26 por acción equivalente a S/ 7,46. Con esta compra Arca Continental tiene una participación igual al 99,78 % de las acciones con derecho a voto de Corporación Lindley