Generating compact classifier systems using a simple artificial immune system

Current artificial immune system (AIS) classifiers have two major problems: 1) their populations of B-cells can grow to huge proportions, and 2) optimizing one B-cell (part of the classifier) at a time does not necessarily guarantee that the B-cell pool (the whole classifier) will be optimized. In this paper, the design of a new AIS algorithm and classifier system called simple AIS is described. It is different from traditional AIS classifiers in that it takes only one B-cell, instead of a B-cell pool, to represent the classifier. This approach ensures global optimization of the whole system, and in addition, no population control mechanism is needed. The classifier was tested on seven benchmark data sets using different classification techniques and was found to be very competitive when compared to other classifiers

Removal of Linear Alkyl Benzenesulphonate by Quaternized Rice Husk

The potential for the use of quaternized rice husk as a sorbent for the removal of linear alkyl benzenesulphonate from aqueous solution was investigated. Both batch and column studies were carried out. The results of the batch studies indicate that sorption was pH dependent, with maximum sorption being attained at pH 2.2. The removal of linear alkyl increased as the temperature increased from 4 to 50°C; thereafter uptake remained constant with further increase in temperature. The presence of anions such as CI', Hl04 ', HPO/ and SO/, had little effect on sorption. Experimental data could be fitted into the Langmuir isotherm with a maximum sorption capacity of 243.9 mg/g at pH 2.2 and 28 ± 2C. In the column studies, results show that a linear relationship existed between service time and bed-depth. However, flow rate of influent had no effect on breakthrough time once it was above 10 ml/min

Numerical comparison between Maxwell stress method and equivalent multipole approach for calculation of the dielectrophoretic force in octupolar cell traps

This work presents detailed numerical calculations of the dielectrophoretic force in octupolar traps designed for single-cell trapping. A trap with eight planar electrodes is studied for spherical and ellipsoidal particles using an indirect implementation of the boundary element method (BEM). Multipolar approximations of orders one to three are compared with the full Maxwell stress tensor (MST) calculation of the electrical force on spherical particles. Ellipsoidal particles are also studied, but in their case only the dipolar approximation is available for comparison with the MST solution. The results show that the full MST calculation is only required in the study of non-spherical particles.Singapore-MIT Alliance (SMA

Measurement of Shear Modulus Profile Using a Continuous Surface Wave Measurement System

For most ground response analyses, the shear modulus is an important parameter to be determined and it has to be measured over a large strain range, so as to characterise the soil behavior under various loading conditions. Laboratory measurement of shear modulus covers a limited strain range depending on the test method. The main difficulty lies in the determination of the shear modulus at very small strains. In this respect, geophysical methods are more attractive. One of these test methods, which uses a continuous surface wave, is used to obtain the shear modulus profile at two sites in Singapore. The Continuous Surface Wave System (CSWS) is a nonintrusive field geophysical test consisting of a vibrator source and several receiver geophones connected to a computer system. The computer collects and analyses the field data, and provides a shear modulus profile at the test site. Conclusions from the field tests support published literature that such field seismic tests are capable of measuring the low-strain shear modulus well. The interpretation of field test data in the absence of specific stratigraphic information can pose some difficulties. An important part in interpreting continuous surface wave measurement data is in the selection of a suitable inversion tool so as to derive the correct shear modulus profile for the site under consideration. A finite element approach (using LS DYNA) is investigated for inversion of field test data. Data obtained from S-wave cross-hole survey are also compared with field tests data obtained using CSWS

Oral cancer secretome: Identification of cancer-associated proteins

This study aims to identify cancer-associated proteins in the secretome of oral cancer cell lines. We have successfully established four primary cell cultures of normal cells with a limited lifespan without human telomerase reverse transcriptase (hTERT) immortalization. The secretome of these primary cell cultures were compared with that of oral cancer cell lines using 2DE. Thirty five protein spots were found to have changed in abundance. Unambiguous identification of these proteins was achieved by MALDI TOF/TOF. In silico analysis predicted that 24 of these proteins were secreted via classical or nonclassical mechanisms. The mRNA expression of six genes was found to correlate with the corresponding protein abundance. Ingenuity Pathway Analysis (IPA) core analysis revealed that the identified proteins were relevant in, and related to, cancer development with likely involvements in tumor growth, metastasis, hyperproliferation, tumorigenesis, neoplasia, hyperplasia, and cell transformation. In conclusion, we have demonstrated that a comparative study of the secretome of cancer versus normal cell lines can be used to identify cancer-associated proteins.Article Link: http://onlinelibrary.wiley.com/doi/10.1002/elps.201300126/abstrac

Independent ferroelectric contributions and rare-earth-induced polarization reversal in multiferroic TbMn2O5

Three independent contributions to the magnetically induced spontaneous polarization of multiferroic TbMn2O5 are uniquely separated by optical second harmonic generation and an analysis in terms of Landau theory. Two of them are related to the magnetic Mn3+/4+ order and are independent of applied fields of up to 7 T. The third contribution is related to the long-range antiferromagnetic Tb3+ order. It shows a drastic decrease upon the application of a magnetic field and mediates the change of sign of the spontaneous electric polarization in TbMn2O5. The close relationship between the rare-earth long-range order and the non-linear optical properties points to isotropic Tb-Tb exchange and oxygen spin polarization as mechanism for this rare-earth induced ferroelectricity.Comment: 8 pages, 5 figure