Characteristics and duties of clinical research nurses: a scoping review

IntroductionThe characteristics and duties of clinical research nurses (CRNs) are constantly developing and changing with the progress of medical technology and increasing needs in patient care. With the continuous deepening and standardization of clinical trials, the importance and status of CRNs during the whole process of clinical trials are also increasingly valued.MethodsA scoping review of studies related to the characteristics and duties of CRNs was conducted to clarify relevant roles and concepts. An electronic search was conducted on three English databases (PubMed, Web of Science, Embase) and two Chinese databases (CNKI and Wanfang database) in December 2023. Two authors independently screened the literature, extracted information from the included literature, and summarized and reported the findings.ResultsA total of 26 articles published between 1991 and 2023 were analyzed, and four characteristics of CRNs were identified as participants and managers of clinical trials, caregivers and protectors of subjects, coordinators of research teams, and educators. Basic knowledge, skills and literacy, communication and coordination ability, and advanced research ability are the competencies required for CRNs.ConclusionFurther studies should focus on the importance of various characteristics of CRNs, so as to improve the quality of clinical trials and promote clinical evidence-based practice

Nutritional evaluation and functional properties of the antioxidant polypeptide from Zanthoxylum bungeanum Maxim seeds kernel protein hydrolysate

Antioxidant polypeptides of Zanthoxylum bungeanum Maxim seeds kernel (ZBMSK) were investigated based on molecular weight distribution, amino acid composition, and functional properties. The polypeptide had a molecular weight distribution of 1026 ~ 2249 Da and 4926 ~ 6398 Da, and was rich in glutamic acid, arginine, aspartic acid, and leucine, but poor in cysteine and tryptophan. Total amino acids were 56.42 g/100 g, and lysine was the first limiting amino acid. The polypeptide showed excellent solubility, viscosity, emulsifying properties, and foam expansion compared with its original protein. In addition, the polypeptide exhibited favorable reduction power and scavenging capacities for DPPH radicals with an IC50 value of 8.86 mg/mL. These results suggest that the polypeptide derived from ZBMSK has potential future application among functional foods, and may be a promising source of natural antioxidants.Se investigaron los polipéptidos antioxidantes de semillas de Zanthoxylum bungeanum (ZBMSK) en base a la distribución del peso molecular, la composición de aminoácidos y las propiedades funcionales. Los polipéptidos presentaban un peso molecular de 1026~2249 Da y 4926~6398 Da, además eran ricos en ácido glutámico, arginina, ácido aspártico y leucina, aunque pobres en cisteína y triptófano. El total de aminoácidos fue de 56,42 g/100 g y la lisina fue el primer aminoácido de limitación. Los polipéptidos mostraron una excelente solubilidad, viscosidad, propiedades emulsionantes y expansión de espuma en comparación con su proteína original. Además, los polipéptidos exhibieron un poder reductor favorable y capacidades de barrido de radicales DPPH con un valor IC50 de 8,86 mg/mL. Estos resultados sugieren que los polipéptidos derivaros de ZBMSK tienen una futura aplicación potencial entre los alimentos funcionales, además podrían ser una prometedora fuente de antioxidantes naturales

Round-trip Slipping Motion of the Circular Flare Ribbon Evidenced in a Fan-spine Jet

status: publishe

Eccentric Compression Properties of FRP–Concrete–Steel Double-Skin Square Tubular Columns

FRP (fiber-reinforced polymer)–concrete–steel double-skin square tubular (FCSST) columns are composed of an outside FRP tube, an inside steel tube and the concrete filled between them. Under the continuous constraint of the outside and inside tube, the strain, strength and ductility of concrete are improved significantly compared with those of traditionally reinforced concrete without lateral restraint. Additionally, the outside and inside tube not only function as the permanent formwork in casting but improve the bending and shear resistance of composite columns. Meanwhile, the hollow core also reduces the weight of the structure. Through the compressive testing of 19 FCSST columns subjected to eccentric load, this study focuses on the influence of eccentricity and layers of axial FRP cloth (away from the loading point) on the evolution of axial strain along the cross-section, axial bearing capacity, axial load–lateral deflection curve and other eccentric properties. The results can provide basis and reference for the design and construction of FCSST columns and are of great theoretical significance and practical value for the application of composite columns in the engineering of structures in a corrosive environment and other harsh conditions

Stereoscopic Observations of an Erupting Mini-filament-driven Two-sided-loop Jet and the Applications for Diagnosing a Filament Magnetic Field

status: publishe

Data_Sheet_1_Characteristics and duties of clinical research nurses: a scoping review.docx

IntroductionThe characteristics and duties of clinical research nurses (CRNs) are constantly developing and changing with the progress of medical technology and increasing needs in patient care. With the continuous deepening and standardization of clinical trials, the importance and status of CRNs during the whole process of clinical trials are also increasingly valued.MethodsA scoping review of studies related to the characteristics and duties of CRNs was conducted to clarify relevant roles and concepts. An electronic search was conducted on three English databases (PubMed, Web of Science, Embase) and two Chinese databases (CNKI and Wanfang database) in December 2023. Two authors independently screened the literature, extracted information from the included literature, and summarized and reported the findings.ResultsA total of 26 articles published between 1991 and 2023 were analyzed, and four characteristics of CRNs were identified as participants and managers of clinical trials, caregivers and protectors of subjects, coordinators of research teams, and educators. Basic knowledge, skills and literacy, communication and coordination ability, and advanced research ability are the competencies required for CRNs.ConclusionFurther studies should focus on the importance of various characteristics of CRNs, so as to improve the quality of clinical trials and promote clinical evidence-based practice.</p

PRMT3-mediated arginine methylation of IGF2BP1 promotes oxaliplatin resistance in liver cancer

Despite being an effective treatment for hepatocellular carcinoma (HCC), resistance to oxaliplatin presents a major obstacle. Here, the authors identify PRMT3-induced methylation of IGF2BP1 resulting in HEG1 stabilisation as a mechanism of oxaliplatin resistance in HCC