The relationships among career adaptability, career commitment, career identity, and career well-being in Chinese nursing undergraduates: A longitudinal study

Exploring the longitudinal relationship between career adaptability, career commitment, career identity, and career well-being among Chinese undergraduate nursing students. A mediation effect analysis was performed. The Career Adaptability Scale, the Chinese version of Career commitment, the Career identity Scale, and the Career well-being Scale were used as research instruments. Six hundred ninety-two nursing students were followed up in two waves to explore the relationships among career adaptability, career commitment, career identity, and career well-being. Model comparison was performed to explore the differences in such relationships between low and high-career interests. Career commitment at T1 mediated the relationship between career adaptability at T1 and career identity at T2 and that between career adaptability at T1 and career well-being at T2. Significant differences were observed between the mediation models of nursing students with high and low career interests. Career commitment plays a longitudinal mediator role in the relationship between career adaptability and career identity and the relationship between career adaptability and career well-being

Clinical significance of soluble adhesion molecules in anti‐NMDAR encephalitis patients

Abstract Increasing evidence indicates that immune system dysfunction affects anti‐N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis. This study aims to investigate the relationship between adhesion molecules and the pathophysiology in anti‐NMDAR encephalitis. Soluble forms of Intercellular adhesion molecule‐1 (sICAM‐1), vascular adhesion molecule‐1 (sVCAM‐1), and L‐selectin (sL‐selectin), were measured in the CSF and serum of 26 participants with anti‐NMDAR encephalitis, 11 patients with schizophrenia and 22 patients with noninflammatory disorders. CSF levels of sICAM‐1, sVCAM‐1 and sL‐selectin were significantly elevated in the anti‐NMDAR encephalitis group. sVCAM‐1 levels were positively associated with modified Rankin scale score in anti‐NMDAR encephalitis patients at the onset and 3‐month follow‐up

Quantitative trait locus analysis of gray leaf spot resistance in the maize IBM Syn10 DH population

The fungal disease of maize known as Gray Leaf Spot (GLS), caused by Cercospora zeae-maydis and Cercospora zeina, is a significant concern in China, southern Africa, and USA. Resistance to GLS is governed by multiple genes with an additive effect and is influenced by both genotype and environment. The most effective way to reduce the cost of production is to develop resistant hybrids. In this study, we utilized the IBM Syn 10 Doubled Haploid (IBM Syn10 DH) population to identify quantitative trait loci (QTL) [Here and throughout manuscript: the plural or QTL is QTL (loci), not QTLs – please correct QTLs to QTL] associated with resistance to gray leaf spot (GLS) in multiple locations including Dehong (2013), Enshi (2013 and 2014), Sayinpan (2019), Xindu (2019 and 2020), and Pixian (2020). The analysis of seven distinct environments revealed a total of 58 QTLs, with 49 QTLs forming 12 discrete clusters distributed across chromosomes 1, 2, 3, 4, 8 and 10. Through comparison with published research findings, we identified co-located QTLs or GWAS loci within eleven clustering intervals. By integrating transcriptome data with genomic structural variations between parental individuals, we have identified a total of 110 genes that exhibit robust disparities in both gene expression and structural alterations (including modifications within coding regions, insertions/deletions, premature terminations, and large segmental changes). Further analysis revealed 19 potential candidate genes encoding conserved resistance gene domains such as: putative leucine-rich repeat receptors, NLP transcription factors, fucosyltransferases, and putative xyloglucan galactosyltransferases. Our results provide a useful resource and linked loci for GLS marker resistance selection (MRS) breeding in maize.This is a manuscript of an article published as Cui, L., Sun, M., Zhang, L. et al. Quantitative trait locus analysis of gray leaf spot resistance in the maize IBM Syn10 DH population. Theor Appl Genet 137, 183 (2024). https://doi.org/10.1007/s00122-024-04694-x. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Posted with permission