Combined anesthesia shows better curative effect and less perioperative neuroendocrine disorder than general anesthesia in early stage NSCLC patients

Objectives We aimed to compare the effects of general anesthesia with combined epidural and general anesthesia in patients with early-stage non-small cell lung carcinoma (NSCLC). Methods Patients scheduled to undergo tumor resection with adjuvant chemoradiotherapy were eligible. Patients in the control group received general anesthesia during surgery, and those in the observation group received combined epidural and general anesthesia. The hemodynamic factors mean arterial pressure (MAP), heart rate, end-tidal carbon dioxide, and oxygen saturation were measured. Serum levels of pro-inflammatory cytokines interleukin (IL)-1, IL-8, high-sensitivity C-reactive protein (hs-CRP), and tumor necrosis factor (TNF)-α as well as β-endorphin were measured by enzyme-linked immunosorbent assay. Serum malondialdehyde (MDA) was measured using the thiobarbituric acid method. Results The incidence of specific adverse events was reduced and overall and disease-free survival were improved in the observation group compared with the control group. MAP was generally lower in the observation group compared with the control group, as were the serum levels of IL-1, IL-8, hs-CRP, TNF-α, and MDA. Conclusions Compared with general anesthesia, combined epidural and general anesthesia may inhibit the occurrence of short-term adverse events and improve long-term outcomes by inhibiting inflammatory responses in patients with early-stage NSCLC after tumor resection. </jats:sec

[N,N-Bis(2,6-diisopropylphenyl)pent-2-ene-2,4-diiminato(1&amp;#8722;)]bis(1,2,4-diazaphosphol-1-yl)aluminium(III)

In the title compound, [Al(C29H41N2)(C2H2N2P)2], the AlIII atom is coordinated by four N atoms from &amp;#946;-diketiminate and 1,2,4-diazaphospholide ligands in a slightly distorted tetrahedral fashion

Особенности плечевой артерии и ее ветвей

Актуальность. В настоящее время большое внимание уделяется индивидуальным особенностям человека. В практике современного врача чаще встречаются не типичные проявления какой-либо патологии или средние значения какого-либо показателя. По данным некоторых исследователей около 20% крупных артериальных стволов верхней конечности имеют нетипичное расположение и ветвление. Материалы и методы: Обзор литературы

Synthesis and Structural Characterization of Homoleptic 1,2,4-Diazaphospholide Alkaline Earth Metal Complexes

The alkaline earth metal complexes [(η²-3,5-<i>t</i>Bu₂dp)­(μ-Mg)­(η¹:η¹-3,5-<i>t</i>Bu₂dp)]₂ (<b>2</b>), {[(η²-3,5-<i>t</i>Bu₂dp)­(μ-η²:η⁵-3,5-<i>t</i>Bu₂dp)­(μ-η²:η¹-3,5-<i>t</i>Bu₂dp)­Ca]₂(μ-Ca)} (<b>3</b>), [Sr­(3,5-<i>t</i>Bu₂dp)₂]_<i>m</i> (<b>4</b>), [Ba­(3,5-<i>t</i>Bu₂dp)₂)]_<i>n</i> (<b>5</b>), and [η¹-{H­(3,5-<i>t</i>Bu₂dp)}₂Ca­(η²-3,5-<i>t</i>Bu₂dp)₂] (<b>6</b>), bearing bulky 1,2,4-diazaphospholide ligands [3,5-<i>t</i>Bu₂dp]⁻ ([3,5-<i>t</i>Bu₂dp]⁻ = 3,5-di<i>-tert</i>-butyl-1,2,4-diazaphospholide), were prepared. The structures of magnesium and calcium 1,2,4-diazaphospholide complexes represent homoleptic 1,2,4-diazaphospholide alkaline earth metal oligomers with a novel array of metal–ligand binding modes

Selective Reaction Based on the Linked Diamido Ligands of Dinuclear Lanthanide Complexes

The dinuclear ytterbium pyridyl diamido complexes [Cp2Yb(THF)]2[μ-η1:η2-(NH)2(C5H3N-2,6)] (1a) and [Cp2Yb(THF)]2[μ-η1:η2-(NH)2(C5H3N-2,3)] (1b) are easily prepared by protonolysis of Cp3Yb with 0.5 equiv of the corresponding diaminopyridine in accepted yields, respectively. Treatment of 1a with 2 equiv of dicyclohexylcarbodiimide (CyNCNCy) in THF at low temperature leads to the isolation of the formal double N−H addition product (Cp2Yb)2[μ-η2:η2-(CyN(CyNH)CN)2(C5H3N-2,6)] (2) in 42% yield. Compound 2 is unstable to heat and slowly isomerized to the mixed neutral/dianionic diguanidinate complex (Cp2Yb)2[μ-η2:η2-(CyNH)2CN(C5H3N-2,6)NC(NCy)2](THF) (3) at room temperature. Similarly, treatment of 1b with 2 equiv of CyNCNCy gives the addition/ isomerization product (Cp2Yb)2[μ-η2:η2:η1-(CyNH)2CN(C5H3N-2,3)NC(NCy)2] (4). Moreover, the reaction of various ytterbium aryl diamido complexes (prepared in situ from [Cp2YbMe]2 and aryldiamine, respectively) with CyNCNCy affords the corresponding addition products (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C6H4-1,4)] (5), (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C6H4-1,3)](6), and (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C13H8-2,7)] (7), respectively. In contrast to pyridyl-bridged bis(guanidinate monoanion) complexes, aryl-bridged bis(guanidinate monoanion) complexes 5−7 are stable even with prolonged heating at 110 °C. All the results not only demonstrate that the presence of the pyridyl bridge can impart the diamido complexes with a unique reactivity and initiate the unexpected reaction sequence but also indicate evidently that the number and distribution of negative charges of the diguanidinate ligand is tunable from double monoanionic units to mixed neutral/dianionic isomers. All the complexes are characterized by elemental analysis and IR spectroscopies. The structures of complexes 1a, 3, 5, 6, and 7 are also determined through X-ray single-crystal diffraction analysis

Selective Reaction Based on the Linked Diamido Ligands of Dinuclear Lanthanide Complexes

The dinuclear ytterbium pyridyl diamido complexes [Cp2Yb(THF)]2[μ-η1:η2-(NH)2(C5H3N-2,6)] (1a) and [Cp2Yb(THF)]2[μ-η1:η2-(NH)2(C5H3N-2,3)] (1b) are easily prepared by protonolysis of Cp3Yb with 0.5 equiv of the corresponding diaminopyridine in accepted yields, respectively. Treatment of 1a with 2 equiv of dicyclohexylcarbodiimide (CyNCNCy) in THF at low temperature leads to the isolation of the formal double N−H addition product (Cp2Yb)2[μ-η2:η2-(CyN(CyNH)CN)2(C5H3N-2,6)] (2) in 42% yield. Compound 2 is unstable to heat and slowly isomerized to the mixed neutral/dianionic diguanidinate complex (Cp2Yb)2[μ-η2:η2-(CyNH)2CN(C5H3N-2,6)NC(NCy)2](THF) (3) at room temperature. Similarly, treatment of 1b with 2 equiv of CyNCNCy gives the addition/ isomerization product (Cp2Yb)2[μ-η2:η2:η1-(CyNH)2CN(C5H3N-2,3)NC(NCy)2] (4). Moreover, the reaction of various ytterbium aryl diamido complexes (prepared in situ from [Cp2YbMe]2 and aryldiamine, respectively) with CyNCNCy affords the corresponding addition products (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C6H4-1,4)] (5), (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C6H4-1,3)](6), and (Cp2Yb)2[μ-η2:η2-{CyN(CyNH)CN}2(C13H8-2,7)] (7), respectively. In contrast to pyridyl-bridged bis(guanidinate monoanion) complexes, aryl-bridged bis(guanidinate monoanion) complexes 5−7 are stable even with prolonged heating at 110 °C. All the results not only demonstrate that the presence of the pyridyl bridge can impart the diamido complexes with a unique reactivity and initiate the unexpected reaction sequence but also indicate evidently that the number and distribution of negative charges of the diguanidinate ligand is tunable from double monoanionic units to mixed neutral/dianionic isomers. All the complexes are characterized by elemental analysis and IR spectroscopies. The structures of complexes 1a, 3, 5, 6, and 7 are also determined through X-ray single-crystal diffraction analysis