Die Bewegung des Absoluten in Hegels „Wissenschaft der Logik“

Ich verstehe die Bewegung des Absoluten in der „Wissenschaft der Logik“ als eine Wechselwirkung in Form des Wechselbestimmens von Sein und Begriff durch das Wesen, wobei dieses, sofern es als Beziehung bzw. Tätigkeit begriffen werden kann, als vermittelnde Wechselwirkung aufgefasst wird. Diese kommt als letztes Moment der Wesenslogik zum Vorschein, so dass die Vermittlungs-Bedeutung der Wesenslogik statt der Substantialitäts-Bedeutung derselben in den Vordergrund gerückt wird. Anschließend sollte die Lesart der „Wissenschaft der Logik“ so vorgestellt werden, dass sich die Logik statt als in zwei Teile, also in die objektive Logik und die subjektive Logik - man könnte diese jeweils als die Logik der Substantialität und die Logik der Subjektivität verstehen - als in drei Momente, also in das Sein, das Wesen und den Begriff, eingeteilt begreift. Dabei werden zwei Pole, also das Sein und der Begriff, mit ihrer Vermittlung, also dem Wesen, zusammen aufgehellt. Jene werden bei Hegel als zwei Gründe in einem Ganzen der Bewegung betrachtet. Jeder von den beiden stellt sich vermittels Heideggers Terminologie zugleich als eine Leere und eine Fülle, oder zugleich als eine unbestimmte Unmittelbarkeit und eine vermittelte Unmittelbarkeit dar, so dass das Sein mit der Idee zu identifizieren ist, obzwar es zuerst als ein unbestimmtes Unmittelbares gilt, und der Begriff, obzwar er im Kontrast zum Sein das entfaltete Ganze besagt, auch noch als ein bestimmender unbestimmter Anfang, d.h. als die transzendentale Apperzeption, festgestellt wird, die von Hegel als ein allumfassendes, an sich Konkretes umgedeutet wird. Als Resultat der vermittelnden Bewegung stellt sich jeder Pol als eine Fülle dar; als Anfang derselben stellt er sich wiederum als eine Leere dar. Der Anfang ist zugleich das Resultat wie das Resultat zugleich der Anfang ist. Der Anfang und das Resultat konstruieren sich in der Ganzheit zur Wechselseitigkeit von Subjekt und Objekt

The cholesterol-hydroxyecdysone-vitellogenin pathway is involved in the longevity of trophocytes and oenocytes of queen honey bees (Apis mellifera)

International audienceAbstractTrophocytes and oenocytes in the abdomen of honey bees do not divide after eclosion; however, trophocytes and oenocytes of queen bees have a longer lifespan and maintain better cellular function than those of worker bees. To explore this phenomenon, we assayed the molecules involved in the cholesterol-hydroxyecdysone-vitellogenin (Vg) pathway in the trophocytes and oenocytes of young and old worker and queen bees. The results showed that Vg and cholesterol levels in hemolymph and cholesterol levels, 20-hydroxyecdysone (20E) levels, and the messenger RNA levels of cytochrome P450 314A1 20-hydroxylase (Cyp314A1), ecdysone receptor isoform A (EcR-A), ecdysone receptor isoform B1 (EcR-B1), ultraspiracle (USP), ecdysone-induced protein 74 (E74), ecdysone-induced protein 75 (E75), broad-complex (BR-C), Vg, and Vg receptor (VgR) in trophocytes and oenocytes were increased in queen bees compared with worker bees. These findings indicated that queen bees have higher expression of molecules in the cholesterol-hydroxyecdysone-Vg pathway than worker bees

Antibodies Elicited by Inactivated Propionibacterium acnes-Based Vaccines Exert Protective Immunity and Attenuate the IL-8 Production in Human Sebocytes: Relevance to Therapy for Acne Vulgaris

Propionibacterium acnes is a key pathogen involved in the progression of inflammation in acne vulgaris. We examined whether vaccination against P. acnes suppressed P. acnes-induced skin inflammation. Inactivation of P. acnes with heat was employed to create a P. acnes-based vaccine. Intranasal immunization in mice with this inactivated vaccine provoked specific antibodies against P. acnes. Most notably, immunization with inactivated vaccines generated in vivo protective immunity against P. acnes challenge and facilitated the resolution of ear inflammation in mice. In addition, antibodies elicited by inactivated vaccines effectively neutralized the cytotoxicity of P. acnes and attenuated the production of proinflammatory cytokine IL-8 in human sebocyte SZ95 cells. Intranasal immunization using heat-inactivated P. acnes-based vaccines provided a simple modality to develop acne vaccines. These observations highlight the concept that development of vaccines targeting microbial products may represent an alternative strategy to conventional antibiotic therapy

Contingencies of Self-Worth on Positive and Negative Events and Their Relationships to Depression

Previous studies have found that the relationship between contingencies of self-worth (CSW) and depression was generally weak. We posited that this is partly because previous studies assumed CSW on positive and negative events as the same construct (one-dimensional CSW), which should be better conceptualized as two distinctive dimensions (two-dimensional CSW) in explaining depression. A total of 393 undergraduates from Taiwan completed the measures regarding one-dimensional CSW, two-dimensional CSW, and depression. After dividing CSW of seven classic domains into two dimensions of positive and negative CSW, the results of confirmatory factor analyses showed that the two-dimensional CSW model had better model fit than the one-dimensional model in all domains. Furthermore, relative to using one-dimensional CSW as a predictor of depression, the variance accounted for largely increased when positive and negative CSW entered simultaneously in the regression equation. The results suggest that CSW on positive and negative events should be seen as two dimensions and this perspective may largely increase the explanatory power of CSW in explaining mental health

Phenotype-based and Self-learning Inter-individual Sleep Apnea Screening with a Level IV Monitoring System

Purpose: We propose a phenotype-based artificial intelligence system that can self-learn and is accurate for screening purposes, and test it on a Level IV monitoring system. Methods: Based on the physiological knowledge, we hypothesize that the phenotype information will allow us to find subjects from a well-annotated database that share similar sleep apnea patterns. Therefore, for a new-arriving subject, we can establish a prediction model from the existing database that is adaptive to the subject. We test the proposed algorithm on a database consisting of 62 subjects with the signals recorded from a Level IV wearable device measuring the thoracic and abdominal movements and the SpO2. Results: With the leave-one cross validation, the accuracy of the proposed algorithm to screen subjects with an apnea-hypopnea index greater or equal to 15 is 93.6%, the positive likelihood ratio is 6.8, and the negative likelihood ratio is 0.03. Conclusion: The results confirm the hypothesis and show that the proposed algorithm has great potential to screen patients with SAS

Quantitative measures of functional outcomes and quality of life in patients with C5 palsy

AbstractBackgroundIt is generally understood that postoperative C5 palsy can occur with anterior or posterior decompression surgery, but functional measures of the palsy have not been well documented. This study aimed to investigate the incidence of C5 palsy in different surgical procedures, examine the correlations between muscle strength, upper extremity functional measures, and health-related quality of life, and to observe potential risk factors contributing to C5 palsy.MethodsOur investigation involved a retrospective study design. A total of 364 patients who underwent decompression surgery were indicated within the selected exclusion criteria. Additionally, 12 C5 palsy patients were recruited. The relationships between the manual muscle test (MMT), the action research arm test (ARAT), the Jebsen test of hand function (JTHF), and the European quality of life-5 dimensions (EQ-5D) were studied, and univariate analyses were performed to search possible risk factors and recovery investigation.ResultsThe data analyzed in the 12 cases and C5 palsy incidences (3.3%) were: 0.7% in anterior procedures (n = 2), 8.8% in posterior procedures (n = 6), and 36.4% in combined procedures (n = 4). Moderate-to-high correlations were observed between the ARAT, JTHF, EQ-5D visual analog scale scores, and MMT (r = 0.636–0.899). There were significant differences in patient age, etiology of cervical lesion, variable decompression procedures, and the number of decompression levels between the C5 palsy and non-C5 palsy groups. For female patients (p = 0.018) and number of decompression levels (p = 0.028), there were significant differences between the complete recovery and the incomplete recovery groups.ConclusionPatients undergoing combined anterior–posterior decompression surgery had the highest incidence of C5 palsy, and correlations between the ARAT, JTHF, EQ-5D visual analog scale clinical tools, and MMT scores supported these findings. Female status and lower decompression levels could also be predictive factors for complete recovery, although additional research is needed to substantiate these findings