Asymmetrically interacting spreading dynamics on complex layered networks

The spread of disease through a physical-contact network and the spread of information about the disease on a communication network are two intimately related dynamical processes. We investigate the asymmetrical interplay between the two types of spreading dynamics, each occurring on its own layer, by focusing on the two fundamental quantities underlying any spreading process: epidemic threshold and the final infection ratio. We find that an epidemic outbreak on the contact layer can induce an outbreak on the communication layer, and information spreading can effectively raise the epidemic threshold. When structural correlation exists between the two layers, the information threshold remains unchanged but the epidemic threshold can be enhanced, making the contact layer more resilient to epidemic outbreak. We develop a physical theory to understand the intricate interplay between the two types of spreading dynamics.Comment: 29 pages, 14 figure

Topological sound

Recently, we witnessed a tremendous effort to conquer the realm of acoustics as a possible playground to test with topologically protected sound wave propagation. In this article, we review the latest efforts to explore with sound waves topological states of quantum matter in two- and three-dimensional systems where we discuss how spin and valley degrees of freedom appear as highly novel ingredients to tailor the flow of sound in the form of one-way edge modes and defect-immune protected acoustic waves. Both from a theoretical stand point and based on contemporary experimental verifications, we summarize the latest advancements of the flourishing research frontier on topological sound.X.J.Z. and L.M.H. are supported by the National Natural Science Foundation of China (Grant No. 11625418 and No. 51732006). M.X. is supported by the U. S. National Science Foundation (Grant No. CBET-1641069). Y.C. acknowledges the support from the National Natural Science Foundation of China (NSFC) (Grant Nos. 11834008,11874215, 11674172, and 11574148) and from the National Basic Research Program of China (Grant No. 2017YFA0303702). J.C. acknowledges the support from the European Research Council (ERC) through the Starting Grant No. 714577 PHONOMETA and from the MINECO through a Ramón y Cajal grant (Grant No. RYC-2015-17156

Small molecules from natural products targeting the Wnt/β-catenin pathway as a therapeutic strategy.

The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental signaling event that plays a critical role in regulating tissue development and maintaining homeostasis, the dysregulation of which contributes to various diseases. Natural products have been widely recognized as a treasure trove of novel drug discovery for millennia, and many clinical drugs are derived from natural small molecules. Mounting evidence has demonstrated that many natural small molecules could inhibit the Wnt/β-catenin pathway, while the efficacy of natural products remains to be determined. Therefore, this paper primarily reviews the targeting mechanism of natural small molecules for aberrant Wnt/β-catenin pathway that is intimately implicated in the pathogenesis of myriad diseases, such as cancers, renal diseases, neurodegenerative diseases and bone disorders. In addition, this review also highlights some natural products that have the potential to halt Wnt/β-catenin pathway, especially for porcupine, the receptors of Wnt ligands, β-catenin and β-catenin-dependent proteins. Additionally, a series of natural small molecules have shown good therapeutic effects against mutations of the Wnt/β-catenin pathway, which may dramatically facilitate the development of natural products in Wnt/β-catenin pathway intervention

The role of EGFR mutation as a prognostic factor in survival after diagnosis of brain metastasis in non-small cell lung cancer: A systematic review and meta-analysis

Abstract Background The brain is a common site for metastasis in non-small-cell lung cancer (NSCLC). This study was designed to evaluate the relationship between the mutational of the epidermal growth factor receptor (EGFR) and overall survival (OS) in NSCLC patients with brain metastases. Methods Searches were performed in PubMed, EmBase, and the Cochrane Library to identify studies evaluating the association of EGFR mutation with OS in NSCLC patients through September 2017. Results 4373 NSCLC patients with brain metastases in 18 studies were involved. Mutated EGFR associated with significantly improved OS compared with wild type. Subgroup analyses suggested that this relationship persisted in studies conducted in Eastern, with retrospective design, with sample size ≥500, mean age of patients ≥65.0 years, percentage male < 50.0%, percentage of patients receiving tyrosine kinase inhibitor ≥30.0%. Finally, although significant publication bias was observed using the Egger test, the results were not changed after adjustment using the trim and fill method. Conclusions This meta-analysis suggests that EGFR mutation is an important predictive factor linked to improved OS for NSCLC patients with brain metastases. It can serve as a useful index in the prognostic assessment of NSCLC patients with brain metastases