150 research outputs found
Secure Single-Server Fuzzy Deduplication without Interactive Proof-of-Ownership in Cloud
The redundant of multimedia data made an unnecessary waste in encrypted cloud storage, unlike text with completely consistent content, multimedia data allows a certain degree of similarity in deduplication, In this work, we focus on the multimedia data which takes a seriously proportion of storage in scenarios such as data outsourcing to propose secure fuzzy deduplication without the additional servers based on Convergent Encryption(CE), say the Single-server Fuzzy Deduplication (SSFD). Compared to the related fuzzy deduplication, SSFD is strong at resisting brute-force attacks caused by server-server collusion, moreover, we also put server-client collusion attacks into security solutions. Additionally, to enhance the security of data, the proposed scheme provides both protection against replay attacks and verification of label consistency and adds no extra communication such as Proof of Ownership(PoW) in interaction. We separately presented a formal security analysis and performed performance at last to prove security solutions and evaluate the experimental results, it shows SSFD provides both a reliable fuzzy images secure deduplication protocol and a computationally feasible solution
Iron Metabolism Genes, Low-Level Lead Exposure, and QT Interval
Background: Cumulative exposure to lead has been shown to be associated with depression of electrocardiographic conduction, such as QT interval (time from start of the Q wave to end of the T wave). Because iron can enhance the oxidative effects of lead, we examined whether polymorphisms in iron metabolism genes [hemochromatosis (), transferrin () C2, and heme oxygenase-1 ()] increase susceptibility to the effects of lead on QT interval in 613 community-dwelling older men. Methods: We used standard 12-lead electrocardiograms, K-shell X-ray fluorescence, and graphite furnace atomic absorption spectrometry to measure QT interval, bone lead, and blood lead levels, respectively. Results: A one-interquartile-range increase in tibia lead level (13 Ī¼g/g) was associated with a 11.35-msec [95% confidence interval (CI), 4.05ā18.65 msec] and a 6.81-msec (95% CI, 1.67ā11.95 msec) increase in the heart-rateācorrected QT interval among persons carrying long alleles and at least one copy of an variant, respectively, but had no effect in persons with short and middle alleles and the wild-type HFE genotype. The lengthening of the heart-rateācorrected QT interval with higher tibia lead and blood lead became more pronounced as the total number (0 vs. 1 vs. ā„2) of gene variants increased (tibia, -trend = 0.01; blood, -trend = 0.04). This synergy seems to be driven by a joint effect between variant and L alleles. Conclusion: We found evidence that gene variants related to iron metabolism increase the impacts of low-level lead exposure on the prolonged QT interval. This is the first such report, so these results should be interpreted cautiously and need to be independently verified
The impact of the introduction of new recognition criteria for overwork-related cardiovascular and cerebrovascular diseases: a cross-country comparison
Cardiovascular and cerebrovascular diseases (CVDs) related to overwork are common in Asia, as is death from overwork, known as karoshi. Japan was the first country in the world to introduce criteria for recognizing overwork-related CVDs in 1961. Taiwan followed Japan in putting in place new policies and then updating these in 2010. We aimed to investigate the effect of introducing the new criteria for recognizing overwork-related CVDs in both countries. We defined the baseline period as the 5 years before launch of the new criteria, then collected data to 5 years after the new criteria. We applied a Poisson regression model to analyze the longitudinal change in rates of overwork-related CVDs before and after, adjusting for indicators of working conditions. Implementation of the new criteria was associated with a 2.58-fold increase in the rate of overwork-related CVDs (p-value < 0.05). However, the examined policy framework in Taiwan still appears to miss a substantial number of cases compared to that are captured by a similar policy framework used to capture overwork-related CVD rates in Japan by a factor of 0.42 (p-value < 0.05). Accordingly, we make a case for enhancements of Taiwanās system for reporting and recognizing overwork-related diseases and deaths
Role of dimensional crossover on spin-orbit torque efficiency in magnetic insulator thin films
Magnetic insulators (MIs) attract tremendous interest for spintronic
applications due to low Gilbert damping and absence of Ohmic loss. Magnetic
order of MIs can be manipulated and even switched by spin-orbit torques (SOTs)
generated through spin Hall effect and Rashba-Edelstein effect in heavy
metal/MI bilayers. SOTs on MIs are more intriguing than magnetic metals since
SOTs cannot be transferred to MIs through direct injection of electron spins.
Understanding of SOTs on MIs remains elusive, especially how SOTs scale with
the film thickness. Here, we observe the critical role of dimensionality on the
SOT efficiency by systematically studying the MI layer thickness dependent SOT
efficiency in tungsten/thulium iron garnet (W/TmIG) bilayers. We first show
that the TmIG thin film evolves from two-dimensional to three-dimensional
magnetic phase transitions as the thickness increases, due to the suppression
of long-wavelength thermal fluctuation. Then, we report the significant
enhancement of the measured SOT efficiency as the thickness increases. We
attribute this effect to the increase of the magnetic moment density in concert
with the suppression of thermal fluctuations. At last, we demonstrate the
current-induced SOT switching in the W/TmIG bilayers with a TmIG thickness up
to 15 nm. The switching current density is comparable with those of heavy
metal/ferromagnetic metal cases. Our findings shed light on the understanding
of SOTs in MIs, which is important for the future development of ultrathin
MI-based low-power spintronics
Association between blood pressure control during aneurysm clipping and functional outcomes in patients with aneurysmal subarachnoid hemorrhage
ObjectivesWe explored the relationship between blood pressure variability (BPV) during craniotomy aneurysm clipping and short-term prognosis in patients with aneurysmal subarachnoid hemorrhage to provide a new method to improve prognosis of these patients.MethodsWe retrospectively analyzed the differences between patient groups with favorable modified Rankin Scale (mRSāā¤ā2) and unfavorable (mRSā>ā2) prognosis, and examined the association between intraoperative BPV and short-term prognosis.ResultsThe intraoperative maximum systolic blood pressure (SBPmax, pā=ā0.005) and the coefficient of variation of diastolic blood pressure (DBPCV, pā=ā0.029) were significantly higher in the favorable prognosis group. SBPmax (OR 0.88, 95%CI 0.80ā0.98) and Neu% (OR 1.22, 95%CI 1.03ā1.46) were independent influence factors on prognosis. Patients with higher standard deviations of SBP (82.7% vs. 56.7%; pā=ā0.030), DBP (82.7% vs. 56.7%; pā=ā0.030), and DBPCV (82.7% vs. 56.7%; pā=ā0.030) had more favorable prognosis.ConclusionHigher SBPmax (ā¤180āmmHg) during the clipping is an independent protective factor for a 90-day prognosis. These results highlight the importance of blood pressure (BP) control for improved prognosis; higher short-term BPV during clipping may be a precondition for a favorable prognosis
Case report and literature review: fatal cerebral fat embolism following facial autologous fat graft
BackgroundSevere cerebral artery embolism is a rare complication of facial autologous fat injection. However, its incidence has markedly increased with the recent rise in facial cosmetic procedures.Case presentationWe report a 31-year-old Chinese woman who presented with unconsciousness 6 h after having undergone a facial autologous fat injection. A neurological examination revealed stupor, bilaterally diminished pupillary light reflexes, right-sided central facial palsy, and no reaction to pain stimulation of right limbs. Diffusion-weighted imaging displayed patchy hyperintense lesions in the left frontal, parietal, and temporal lobes. Magnetic resonance angiography demonstrated fat embolism in the left internal carotid artery, anterior cerebral artery, and middle cerebral artery. We immediately performed mechanical thrombectomy under sufficient preoperative preparations but failed to achieve complete recanalization. Pathological examination of the embolus confirmed the presence of adipocytes. Although we actively administered symptomatic and supportive treatments, the patient eventually died due to the progression of cerebral herniation and systemic infection.ConclusionDue to the ineffectiveness of current treatment and the inferior prognosis, fat embolism, a severe complication of autologous fat graft, should draw the attention of both plastic surgeons and neurologists so that actions may be taken for both its prevention and treatment
DL3DV-10K: A Large-Scale Scene Dataset for Deep Learning-based 3D Vision
We have witnessed significant progress in deep learning-based 3D vision,
ranging from neural radiance field (NeRF) based 3D representation learning to
applications in novel view synthesis (NVS). However, existing scene-level
datasets for deep learning-based 3D vision, limited to either synthetic
environments or a narrow selection of real-world scenes, are quite
insufficient. This insufficiency not only hinders a comprehensive benchmark of
existing methods but also caps what could be explored in deep learning-based 3D
analysis. To address this critical gap, we present DL3DV-10K, a large-scale
scene dataset, featuring 51.2 million frames from 10,510 videos captured from
65 types of point-of-interest (POI) locations, covering both bounded and
unbounded scenes, with different levels of reflection, transparency, and
lighting. We conducted a comprehensive benchmark of recent NVS methods on
DL3DV-10K, which revealed valuable insights for future research in NVS. In
addition, we have obtained encouraging results in a pilot study to learn
generalizable NeRF from DL3DV-10K, which manifests the necessity of a
large-scale scene-level dataset to forge a path toward a foundation model for
learning 3D representation. Our DL3DV-10K dataset, benchmark results, and
models will be publicly accessible at https://dl3dv-10k.github.io/DL3DV-10K/
Goose STING mediates IFN signaling activation against RNA viruses
Stimulator of the interferon gene (STING) is involved in mammalian antiviral innate immunity as an interferon (IFN) activator. However, there is still a lack of clarity regarding the molecular characterization of goose STING (GoSTING) and its role in the innate immune response. In the present study, we cloned GoSTING and performed a series of bioinformatics analyses. GoSTING was grouped into avian clades and showed the highest sequence similarity to duck STING. The in vitro experiments showed that the mRNA levels of GoSTING, IFNs, IFN-stimulated genes (ISGs), and proinflammatory cytokines were significantly upregulated in goose embryo fibroblast cells (GEFs) infected with Newcastle disease virus (NDV). Overexpression of GoSTING in DF-1 cells and GEFs strongly activated the IFN-Ī² promoter as detected by a dual-luciferase reporter assay. Furthermore, overexpression of GoSTING induced the expression of other types of IFN, ISGs, and proinflammatory cytokines and inhibited green fluorescent protein (GFP)-tagged NDV (NDV-GFP) and GFP-tagged vesicular stomatitis virus (VSV) (VSV-GFP) replication in vitro. In conclusion, these data suggest that GoSTING is an important regulator of the type I IFN pathway and is critical in geeseās innate immune host defense against RNA viruses
Entire Peroxidation Reaction System of Myeloperoxidase Correlates with Progressive Low-Density Lipoprotein Modifications via Reactive Aldehydes in Atherosclerotic Patients with Hypertension
Background/Aims: Reactive oxygen species (ROS) contribute to the dysfunction of serum lipoproteins, which triggers lipid metabolism abnormalities in the development of atherosclerosis and hypertension. Myeloperoxidase (MPO) is involved in ROS modifications, triggering lipid peroxidation and aldehyde formation. However, the relationship between the entirety of the MPO reaction system and oxidative modification of serum lipoproteins in atherosclerotic patients with hypertension remains unclear. Methods: We measured MPO activity (peroxidation and chlorination), 4-hydroxynonenal-modified low-density lipoprotein (HNE-LDL), malondialdehyde-modified low-density lipoprotein (MDA-LDL), H2O2, reduced glutathione (GSH), and oxidized glutathione (GSSG) using a corresponding commercial kit in atherosclerotic patients with hypertension and healthy participants. We used Spearmanās correlation analysis to investigate the correlation between MPO activity and the levels of these oxidative and anti-oxidative stress-related indices and performed response surface regression to investigate the relationship between the MPO reaction system and the levels of HNE-LDL, MDA-LDL, and the GSH/GSSG ratio. Results: Our results showed no association between the levels of MPO peroxidation activity, MPO chlorination activity, H2O2, and Cl- and those of HNE-LDL, MDA-LDL, GSH, and GSSG, and the GSH/GSSG ratio in healthy participants. In addition, no effects of the peroxidation reaction system of MPO (PRSM) and the chlorination reaction system of MPO (CRSM) on GSH/GSSG were found in this investigation. However, we found that the PRSM rather than the CRSM correlated with progressive low-density lipoprotein (LDL) modifications by HNE-LDL and MDA-LDL in atherosclerotic patients with hypertension. Conclusion: The PRSM rather than the CRSM correlated with progressive LDL modifications via reactive aldehydes in atherosclerotic patients with hypertension. Further investigation is warranted to evaluate whether the PRSM may serve as a potential index for monitoring LDL function in atherosclerosis and hypertension
Therapeutic Implications of PPAR Ī³
Osteosarcoma (OS) is the most common nonhematologic malignancy of bone in children and adults. Although dysregulation of tumor suppressor genes and oncogenes, such as Rb, p53, and the genes critical to cell cycle control, genetic stability, and apoptosis have been identified in OS, consensus genetic changes that lead to OS development are poorly understood. Disruption of the osteogenic differentiation pathway may be at least in part responsible for OS tumorigenesis. Current OS management involves chemotherapy and surgery. Peroxisome proliferator-activated receptor (PPAR) agonists and/or retinoids can inhibit OS proliferation and induce apoptosis and may inhibit OS growth by promoting osteoblastic terminal differentiation. Thus, safe and effective PPAR agonists and/or retinoid derivatives can be then used as adjuvant therapeutic drugs for OS therapy. Furthermore, these agents have the potential to be used as chemopreventive agents for the OS patients who undergo the resection of the primary bone tumors in order to prevent local recurrence and/or distal pulmonary metastasis
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