2,191 research outputs found
Nominal Logic Programming
Nominal logic is an extension of first-order logic which provides a simple
foundation for formalizing and reasoning about abstract syntax modulo
consistent renaming of bound names (that is, alpha-equivalence). This article
investigates logic programming based on nominal logic. We describe some typical
nominal logic programs, and develop the model-theoretic, proof-theoretic, and
operational semantics of such programs. Besides being of interest for ensuring
the correct behavior of implementations, these results provide a rigorous
foundation for techniques for analysis and reasoning about nominal logic
programs, as we illustrate via examples.Comment: 46 pages; 19 page appendix; 13 figures. Revised journal submission as
of July 23, 200
Negative thermal expansion of MgB in the superconducting state and anomalous behavior of the bulk Gr\"uneisen function
The thermal expansion coefficient of MgB is revealed to change
from positive to negative on cooling through the superconducting transition
temperature . The Gr\"uneisen function also becomes negative at
followed by a dramatic increase to large positive values at low temperature.
The results suggest anomalous coupling between superconducting electrons and
low-energy phonons.Comment: 5 figures. submitted to Phys. Rev. Let
A dependent nominal type theory
Nominal abstract syntax is an approach to representing names and binding
pioneered by Gabbay and Pitts. So far nominal techniques have mostly been
studied using classical logic or model theory, not type theory. Nominal
extensions to simple, dependent and ML-like polymorphic languages have been
studied, but decidability and normalization results have only been established
for simple nominal type theories. We present a LF-style dependent type theory
extended with name-abstraction types, prove soundness and decidability of
beta-eta-equivalence checking, discuss adequacy and canonical forms via an
example, and discuss extensions such as dependently-typed recursion and
induction principles
Muscle Synergies Obtained from Comprehensive Mapping of the Cortical Forelimb Representation Using Stimulus Triggered Averaging of EMG Activity
This work is licensed under a Creative Commons Attribution 4.0 International License.Neuromuscular control of voluntary movement may be simplified using muscle synergies similar to those found using non-negative matrix factorization. We recently identified synergies in electromyography (EMG) recordings associated with both voluntary movement and movement evoked by high-frequency long-duration intracortical microstimulation applied to the forelimb representation of the primary motor cortex (M1). The goal of this study was to use stimulus-triggered averaging (StTA) of EMG activity to investigate the synergy profiles and weighting coefficients associated with poststimulus facilitation, as synergies may be hard-wired into elemental cortical output modules and revealed by StTA. We applied StTA at low (LOW, ∼15 μA) and high intensities (HIGH, ∼110 μA) to 247 cortical locations of the M1 forelimb region in two male rhesus macaques while recording the EMG of 24 forelimb muscles. Our results show that 10–11 synergies accounted for 90% of the variation in poststimulus EMG facilitation peaks from the LOW-intensity StTA dataset while only 4–5 synergies were needed for the HIGH-intensity dataset. Synergies were similar across monkeys and current intensities. Most synergy profiles strongly activated only one or two muscles; all joints were represented and most, but not all, joint directions of motion were represented. Cortical maps of the synergy weighting coefficients suggest only a weak organization. StTA of M1 resulted in highly diverse muscle activations, suggestive of the limiting condition of requiring a synergy for each muscle to account for the patterns observed
Nominal Unification of Higher Order Expressions with Recursive Let
A sound and complete algorithm for nominal unification of higher-order
expressions with a recursive let is described, and shown to run in
non-deterministic polynomial time. We also explore specializations like nominal
letrec-matching for plain expressions and for DAGs and determine the complexity
of corresponding unification problems.Comment: Pre-proceedings paper presented at the 26th International Symposium
on Logic-Based Program Synthesis and Transformation (LOPSTR 2016), Edinburgh,
Scotland UK, 6-8 September 2016 (arXiv:1608.02534
College Students’ Use of Social Media and E-Cigarettes: How Correctly Identifying Platform Type Influences Findings
The purpose of this study was to examine how college students post or share JUUL-related content on social media. Using a sequential explanatory mixed-methods design, current JUUL users (n = 667) completed a cross-sectional survey in March of 2019, then 51 participants completed in-person follow-up interviews in April of 2019. Survey questions asked about JUUL-related social media postings and commenting history as well as demographic questions. Interview participants were asked to explain their survey responses and were then shown the survey results and asked for reasons why they and others did not post or comment about JUUL on social media. Qualitative data were coded independently by two coders using NVivo, and analyzed for themes. Survey participant (ages 18-24, mean age 20 years, 50.5% female, and 80.6% white) responses showed 81% had not posted a JUUL-focused comment on social media and had not posted a picture of themselves JUULing in the past year. However, interviewees reported they had continued to post about JUUL on social media but moved away from more public social media accounts (e.g., Facebook); private Instagram and Snapchat accounts were used to post both JUUL use and JUUL-focused content without risk of damaging their personal image to family or potential employers. How social media use questions are asked is critical for understanding college student promotion of JUULing and social norms. Young adults protect their social media presence by not including themselves in JUUL-focused content; thus, the spread of JUULing through private social media like Snapchat or Finstas may not be identified and young adults normalize JUUL use through memes or images
Exosome-mediated shuttling of microRNA-29 regulates HIV Tat and morphine-mediated neuronal dysfunction.
Neuronal damage is a hallmark feature of HIV-associated neurological disorders (HANDs). Opiate drug abuse accelerates the incidence and progression of HAND; however, the mechanisms underlying the potentiation of neuropathogenesis by these drugs remain elusive. Opiates such as morphine have been shown to enhance HIV transactivation protein Tat-mediated toxicity in both human neurons and neuroblastoma cells. In the present study, we demonstrate reduced expression of the tropic factor platelet-derived growth factor (PDGF)-B with a concomitant increase in miR-29b in the basal ganglia region of the brains of morphine-dependent simian immunodeficiency virus (SIV)-infected macaques compared with the SIV-infected controls. In vitro relevance of these findings was corroborated in cultures of astrocytes exposed to morphine and HIV Tat that led to increased release of miR-29b in exosomes. Subsequent treatment of neuronal SH-SY5Y cell line with exosomes from treated astrocytes resulted in decreased expression of PDGF-B, with a concomitant decrease in viability of neurons. Furthermore, it was shown that PDGF-B was a target for miR-29b as evidenced by the fact that binding of miR-29 to the 3\u27-untranslated region of PDGF-B mRNA resulted in its translational repression in SH-SY5Y cells. Understanding the regulation of PDGF-B expression may provide insights into the development of potential therapeutic targets for neuronal loss in HIV-1-infected opiate abusers
Towards meta-interpretive learning of programming language semantics
We introduce a new application for inductive logic programming: learning the
semantics of programming languages from example evaluations. In this short
paper, we explored a simplified task in this domain using the Metagol
meta-interpretive learning system. We highlighted the challenging aspects of
this scenario, including abstracting over function symbols, nonterminating
examples, and learning non-observed predicates, and proposed extensions to
Metagol helpful for overcoming these challenges, which may prove useful in
other domains.Comment: ILP 2019, to appea
Forward electromagnetic scattering models for sea ice
Journal ArticleRecent advances in forward modeling of the electromagnetic scattering properties of sea ice are presented. In particular, the principal results include the following: 1) approximate calculations of electromagnetic scattering from multilayer random media with rough interfaces, based on the distorted Born approximation and radiative transfer (RT) theory; 2) comprehensive theory of the effective complex permittivity of sea ice based on rigorous bounds in the quasi-static case and strong fluctuation theory in the weakly scattering regime; 3) rigorous analysis of the Helmholtz equation and its solutions for idealized sea ice models, which has led in the one dimensional (1-D) case to nonlinear generalizations of classical theorems in Fourier analysis
Rhesus Monkeys See Who They Hear: Spontaneous Cross-Modal Memory for Familiar Conspecifics
Rhesus monkeys gather much of their knowledge of the social world through visual input and may preferentially represent this knowledge in the visual modality. Recognition of familiar faces is clearly advantageous, and the flexibility and utility of primate social memory would be greatly enhanced if visual memories could be accessed cross-modally either by visual or auditory stimulation. Such cross-modal access to visual memory would facilitate flexible retrieval of the knowledge necessary for adaptive social behavior. We tested whether rhesus monkeys have cross-modal access to visual memory for familiar conspecifics using a delayed matching-to-sample procedure. Monkeys learned visual matching of video clips of familiar individuals to photographs of those individuals, and generalized performance to novel videos. In crossmodal probe trials, coo-calls were played during the memory interval. The calls were either from the monkey just seen in the sample video clip or from a different familiar monkey. Even though the monkeys were trained exclusively in visual matching, the calls influenced choice by causing an increase in the proportion of errors to the picture of the monkey whose voice was heard on incongruent trials. This result demonstrates spontaneous cross-modal recognition. It also shows that viewing videos of familiar monkeys activates naturally formed memories of real monkeys, validating the use of video stimuli in studies of social cognition in monkeys
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