133 research outputs found
Context-aware Event Forecasting via Graph Disentanglement
Event forecasting has been a demanding and challenging task throughout the
entire human history. It plays a pivotal role in crisis alarming and disaster
prevention in various aspects of the whole society. The task of event
forecasting aims to model the relational and temporal patterns based on
historical events and makes forecasting to what will happen in the future. Most
existing studies on event forecasting formulate it as a problem of link
prediction on temporal event graphs. However, such pure structured formulation
suffers from two main limitations: 1) most events fall into general and
high-level types in the event ontology, and therefore they tend to be
coarse-grained and offers little utility which inevitably harms the forecasting
accuracy; and 2) the events defined by a fixed ontology are unable to retain
the out-of-ontology contextual information. To address these limitations, we
propose a novel task of context-aware event forecasting which incorporates
auxiliary contextual information. First, the categorical context provides
supplementary fine-grained information to the coarse-grained events. Second and
more importantly, the context provides additional information towards specific
situation and condition, which is crucial or even determinant to what will
happen next. However, it is challenging to properly integrate context into the
event forecasting framework, considering the complex patterns in the
multi-context scenario. Towards this end, we design a novel framework named
Separation and Collaboration Graph Disentanglement (short as SeCoGD) for
context-aware event forecasting. Since there is no available dataset for this
novel task, we construct three large-scale datasets based on GDELT.
Experimental results demonstrate that our model outperforms a list of SOTA
methods.Comment: KDD 2023, 9 pages, 7 figures, 4 table
Recurrent renal secondary hyperparathyroidism caused by supernumerary mediastinal parathyroid gland and parathyromatosis: A case report
BackgroundSurgical parathyroidectomy (PTX) is necessary for patients with severe and progressive secondary hyperparathyroidism (SHPT) refractory to medical treatment. Recurrence of SHPT after PTX is a serious clinical problem. Both supernumerary mediastinal parathyroid gland and parathyromatosis are the rare causes of recurrent renal SHPT. We report a rare case of recurrent renal SHPT due to supernumerary mediastinal parathyroid gland and parathyromatosis.Case presentationA 53-year-old man underwent total parathyroidectomy with autotransplantation due to the drug-refractory SHPT 17 years ago. In the last 11 months, the patient experienced symptoms including bone pain and skin itch, and the serum intact parathyroid hormone (iPTH) level elevated to 1,587ā
pg/ml. Ultrasound detected two hypoechoic lesions located at the dorsal area of right lobe of the thyroid gland, and both lesions presented as characteristics of hyperparathyroidism in contrast-enhanced ultrasound. 99mTc-MIBI/SPECT detected a nodule in the mediastinum. A reoperation involved a cervicotomy for excising parathyromatosis lesions and the surrounding tissue and a thoracoscopic surgery for resecting a mediastinal parathyroid gland. According to a histological examination, two lesions behind the right thyroid lobe and one lesion in the central region had been defined as parathyromatosis. A nodule in the mediastinum was consistent with hyperplastic parathyroid. The patient remained well for 10 months with alleviated symptoms and stabilized iPTH levels in the range of 123ā201ā
pg/ml.ConclusionAlthough rare, recurrent SHPT may be caused by a coexistence of both supernumerary parathyroid glands and parathyromatosis, which should receive more attention. The combination of imaging modalities is important for reoperative locations of parathyroid lesions. To successfully treat parathyromatosis, all the lesions and the surrounding tissue must be excised. Thoracoscopic surgery is a reliable and safe approach for the resection of ectopic mediastinal parathyroid glands
Towards Cyber Security for Low-Carbon Transportation: Overview, Challenges and Future Directions
In recent years, low-carbon transportation has become an indispensable part
as sustainable development strategies of various countries, and plays a very
important responsibility in promoting low-carbon cities. However, the security
of low-carbon transportation has been threatened from various ways. For
example, denial of service attacks pose a great threat to the electric vehicles
and vehicle-to-grid networks. To minimize these threats, several methods have
been proposed to defense against them. Yet, these methods are only for certain
types of scenarios or attacks. Therefore, this review addresses security aspect
from holistic view, provides the overview, challenges and future directions of
cyber security technologies in low-carbon transportation. Firstly, based on the
concept and importance of low-carbon transportation, this review positions the
low-carbon transportation services. Then, with the perspective of network
architecture and communication mode, this review classifies its typical attack
risks. The corresponding defense technologies and relevant security suggestions
are further reviewed from perspective of data security, network management
security and network application security. Finally, in view of the long term
development of low-carbon transportation, future research directions have been
concerned.Comment: 34 pages, 6 figures, accepted by journal Renewable and Sustainable
Energy Review
In Situ SEM Torsion Test of Metallic Glass Microwires Based on Micro Robotic Manipulation
Microwires, such as metallic, semiconductor, and polymer microwires and carbon fibers, have stimulated great interest due to their importance in various structural and functional applications. Particularly, metallic glass (MG) microwires, because of their amorphous atoms arrangement, have some unique mechanical properties compared with traditional metals. Despite the fact that substantial research efforts have been made on the mechanical characterizations of metallic glass microwires under tension or flexural bending, the mechanical properties of microwires under torsional loading have not been well studied, mainly due to the experimental difficulties, such as the detection of torsion angle, quantitative measurement of the torsional load, and the alignment between the specimen and torque meter. In this work, we implemented the in situ SEM torsion tests of individual La50Al30Ni20 metallic glass (MG) microwires successfully based on a self-developed micro robotic mechanical testing system. Unprecedented details, such as the revolving vein-pattern along the torsion direction on MG microwires fracture surface, were revealed. Our platform could provide critical insights into understanding the deformation mechanisms of other microwires under torsional loading and can even be further used for robotic micromanufacturing
Effect of Maillard Reaction on Tropomyosin Immunoreactivity in Mactra veneriformis
In this study, xylose and arabinose were subjected separately to Maillard reaction with a crude extract of Mactra veneriformis under dry-heating conditions. The immunoreactivity and digestion properties of the Maillard reaction products (MRPs) were analyzed, finding that the Maillard reaction could reduce the immunoreactivity of allergens derived from Mactra veneriformis, increase the continuous digestion rate of the crude extract in simulated gastrointestinal fluid, and reduce the particle diameter of the digestion products. After that, TM in the MRPs was separated and purified, and its structural characteristics and immunoreactivity were analyzed. The results showed that the Ī±-helix content of TM decreased and the Ī²-sheet, Ī²-turn, and random coil contents increased after the Maillard reaction, the surface hydrophobicity increased, and the spatial structure changed, which eventually led to a reduction in the immunoreactivity of TM. This study provides a theoretical basis for the development of hypoallergenic clam products
Rapid and Visual Detection of Monkey B Virus Based on Recombinase Polymerase Amplification
Monkey B virus (BV) infection in humans and other macaque species has a mortality rate of approximately 80%. Because BV infects humans through bites, scratches, and other injuries inflicted by macaques, the simple and rapid diagnosis of BV in field laboratories is of great importance to protect veterinarians, laboratory researchers, and support personnels from the threat of infection. Two recombinase polymerase amplification (RPA) assays with a closed vertical flow (VF) visualization strip (RPA-VF-UL27 and RPA-VF-US6) were developed that target two conserved genes combined with a one-off, closed visualization strip device. We compared the sensitivities and specificities of the two assays after optimization of the reaction conditions. The performance of RPA-VF-US6 at room temperature was determined to evaluate its potential in point-of-care (POC) testing. RPA-VF-US6 specifically detected the positive plasmid control (rather than nucleic acids of herpesviruses) with a detection limit of 28 copies, while RPA-VF-UL27 had cross-reactivity with HSV-1, but even 3.4 copies of plasmid standards were readout by this assay. Moreover, RPA-VF-US6 had excellent performance at room temperature (the detection limit was 2,800 plasmid copies), indicating the potential of RPA-VF-US6 in POC testing. We developed two RPA assays for BV visualization diagnosis. RPA-VF-US6 is a simple, rapid, and specific detection method for BV. The entire reaction can be performed at a constant temperature within 30 min, suggesting the potential of RPA-VF-US6 for POC testing in field laboratories without sophisticated instruments
Transposable elements cause the loss of self-incompatibility in citrus
Self-incompatibility (SI) is a widespread prezygotic mechanism for flowering plants to avoid inbreeding depression and promote genetic diversity. Citrus has an S-RNase-based SI system, which was frequently lost during evolution. We previously identified a single nucleotide mutation in Sm-RNase, which is responsible for the loss of SI in mandarin and its hybrids. However, little is known about other mechanisms responsible for conversion of SI to self-compatibility (SC) and we identify a completely different mechanism widely utilized by citrus. Here, we found a 786-bp miniature inverted-repeat transposable element (MITE) insertion in the promoter region of the FhiS2-RNase in Fortunella hindsii Swingle (a model plant for citrus gene function), which does not contain the Sm-RNase allele but are still SC. We demonstrate that this MITE plays a pivotal role in the loss of SI in citrus, providing evidence that this MITE insertion prevents expression of the S-RNase; moreover, transgenic experiments show that deletion of this 786-bp MITE insertion recovers the expression of FhiS2-RNase and restores SI. This study identifies the first evidence for a role for MITEs at the S-locus affecting the SI phenotype. A family-wide survey of the S-locus revealed that MITE insertions occur frequently adjacent to S-RNase alleles in different citrus genera, but only certain MITEs appear to be responsible for the loss of SI. Our study provides evidence that insertion of MITEs into a promoter region can alter a breeding strategy and suggests that this phenomenon may be broadly responsible for SC in species with the S-RNase system
PSR J1926-0652: A Pulsar with Interesting Emission Properties Discovered at FAST
We describe PSR J1926-0652, a pulsar recently discovered with the
Five-hundred-meter Aperture Spherical radio Telescope (FAST). Using sensitive
single-pulse detections from FAST and long-term timing observations from the
Parkes 64-m radio telescope, we probed phenomena on both long and short time
scales. The FAST observations covered a wide frequency range from 270 to 800
MHz, enabling individual pulses to be studied in detail. The pulsar exhibits at
least four profile components, short-term nulling lasting from 4 to 450 pulses,
complex subpulse drifting behaviours and intermittency on scales of tens of
minutes. While the average band spacing P3 is relatively constant across
different bursts and components, significant variations in the separation of
adjacent bands are seen, especially near the beginning and end of a burst. Band
shapes and slopes are quite variable, especially for the trailing components
and for the shorter bursts. We show that for each burst the last detectable
pulse prior to emission ceasing has different properties compared to other
pulses. These complexities pose challenges for the classic carousel-type
models.Comment: 13pages with 12 figure
- ā¦