Empirical Likelihood Confidence Intervals for Linear Regression Coefficients

AbstractNonparametric versions of Wilks′ theorem are proved for empirical likelihood estimators of slope and mean parameters for a simple linear regression model. They enable us to construct empirical likelihood confidence intervals for these parameters. The coverage errors of these confidence intervals are of order n−1 and can be reduced to order n−2 by Bartlett correction

How Long Can Cultural Events Elevate Group Identity Salience? The Mediating Role of Affective Adaptation

Cultural events have been found to make one’s group identity temporarily more salient. How long such an elevated sense of identity can endure remains, however, an empirical question. Building upon the model of affective adaptation, we propose that the elevated sense of group identity may decrease quickly during a culturally important event, and this process is mediated by the decline of positive emotions during the event. Consistent with this prediction, a diary study (Study 1) with a Chinese sample observed that Chinese identity was very salient at the beginning of the 2008 Beijing Olympics and then was gradually neutralized during the event. Moreover, the dissipation of positive emotions during the event mediated temporal change of the salience of Chinese identity. An experiment (Study 2) further showed that positive emotions during national-identity-related events could create the initial elevation and subsequent decline of the salience of the group identity

Diffuse interstitial and multiple cavitary lung lesions due to Talaromyces marneffei infection in a non-HIV patient

AbstractA 57-year-old man presented with unproductive cough and dyspnea for 6 months in Fujian Province, China. His misuse of a large amount of steroids (accumulated dose equivalent to 3530 mg prednisolone) resulted in Talaromyces marneffei infection. Chest computed tomographic scan revealed diffuse interstitial and multiple cavitary lung lesions. Treatment with amphotericin B combined with itraconazole resulted in total recovery, with marked regression of lung lesions

Near-capacity three-stage MMSE turbo equalization using irregular convolutional codes

Traditional Turbo EQualization (TEQ) schemes suffer from residual bit errors due to the non-recursive nature of the channel imposing Inter-Symbol-Interference (ISI). The performance of the traditional TEQ scheme may, however, be improved if an intermediate recursive channel codec is invoked, which results in a three-stage serially concatenated system. This intermediate code is necessary, especially when the inner module cannot be rendered recursive, for example, when a Minimum Mean Square Error (MMSE) equalizer is invoked. Our EXtrinsic Information Transfer (EXIT) chart analysis explicitly explains the performance gain, and based on this explanation IRregular Convolutional Codes (IRCCs) are constructed to be used as the outer code for the sake of achieving near capacity performance. Furthermore, the proposed analysis and design procedure may be applied in the context of diverse iterative receivers employing multiple soft-in/soft-out (SISO) modules

A REAL TIME MONITORING MODEL OF THE CALCIUM CARBONATE FOULING INDUCTION PERIOD BASED ON THE CONDUCTANCE TITRATION

A new method has been developed to monitor the calcium carbonate fouling induction period (CCFIP) in real time. Based on the conductance titration, this paper investigated the forming process of CCFIP by a staticdynamic combined simulation experiment unit. With the help of titration analysis (that is titrimetry), an accurate definition of CCFIP and the corresponding real time monitoring model were built up. The investigation results show that the proposed model applies not only to measure the CCFIP in real time, but also applies to an investigation of the influence of various factors on the CCFIP

Molecular cytogenetic aberrations in patients with multiple myeloma studied by interphase fluorescence in situ hybridization

Background: Multiple myeloma (MM) is an incurable hematological disorder characterized by the accumulation of malignant plasma cells within the bone marrow (BM). The clinical heterogeneity of MM is dictated by the cytogenetic aberrations present in the clonal plasma cells (PCs). Cytogenetic studies in MM are hampered by the hypoproliferative nature of plasma cells in MM. Therefore, fluorescence in situ hybridization (FISH) analysis combined with magnetic-activated cell sorting (MACS) is an attractive alternative for evaluation of numerical and structural chromosomal changes in MM. Methods: Interphase FISH studies with three different specific probes for the regions containing 13q14.3 (D13S319), 14q32 (IGHC/IGHV) and 1q12(CEP1 ) were performed in 48 MM patients. Interphase FISH studies with LSI IGH/CCND1, LSI IGH/FGFR3, and LSI IGH/MAF probes were used to detect t(11;14)(q13;q32), t(4;14)(p16;q32), and t(14;16)(q32;q23) in patients with 14q32 rearrangement. Results: Molecular cytogenetic aberrations were found in 40 (83.3%) of the 48 MM patients. 13 patients (27.1%) simultaneously had 13q deletion/monosomy 13 [del(13q14)], illegitimate IGH rearrangement and chromosome 1 abnormality. Del(13q14) was detected in 21 cases (43.7%), and illegitimate IGH rearrangements in 29 (60.4%) including 6 with t(11;14) and 5 with t(4;14). None of 9 patients with illegitimate IGH rearrangements and without t(11;14) or t(4;14) we detected had t(14;16) (q32;q23). 24 of the 48 MM patients (50%) had chromosome 1 abnormalities. Among 21 patients with del(13q14), 15 patients had Amp1q12;16 had IgH rearrangements. Whereas, among 27 cases without del(13q14), 8 had Amp1q12; 13 had IgH rearrangements. There was a strong association between del(13q14) and Amp1q12(c2 = 8.26, р < 0.01), and between del(13q14) and IgH rearrangement(c2 = 3.88, p < 0.05). Conclusion: 13q deletion/monosomy 13, IGH rearrangement and chromosome 1 abnormality are frequent in MM. They are not randomly distributed, but strongly interconnected. Interphase FISH technique combined with MACS using CD138-specific antibody is a highly sensitive technique at detecting molecular cytogenetic aberrations in MM.Обоснование: множественная миелома (MM) — неизлечимое гематологическое заболевание, характеризирующееся накоплением злокачественных плазматических клеток в костном мозге (КM). Клиническая гетерогенность MM определяется цитогенетическими аберрациями, присутствующими в клоне плазматических клеток (ПК). Цитогенетические исследования MM осложнены гипопролиферативными особенностями ПК. В связи с этим флуоресцентная гибридизация in situ (FISH) в комбинации с сортировкой клеток, активированных магнитными полями (MACS) представляется достойной альтернативой методам оценки точечных и структурных изменений хромосом при MM. Методы: интерфазные исследования методом FISH с использованием трех различных специфических зондов для участков, содержащих 13q14.3 (D13S319), 14q32 (IGHC/IGHV) и 1q12(CEP1), проводили у 48 больных с MM. Интерфазные исследования методом FISH с использованием зондов LSI IGH/CCND1, LSI IGH/FGFR3 и LSI IGH/MAF применяли для детекции t(11;14)(q13;q32), t(4;14)(p16;q32), и t(14;16)(q32;q23) у пациентов с перестройкой 14q32. Результаты: молекулярные цитогенетические аберрации выявляли у 40 (83,3%) из 48 больных с MM. У 13 пациентов (27,1%) одновременно определены 13q делеция/моносомия 13 [del(13q14)], аномальная перестройка IGH и аномалия хромосомы 1. Del(13q14) детектировали в 21 случае (43,7%), а аномальные перестройки IGH — в 29 (60,4%), в том числе у 6 пациентов с t(11;14) и 5 с t(4;14). Ни у одного из 9 больных с аномальными перестройками IGH и без t(11;14) или t(4;14) не выявляли транслокацию t(14;16) (q32;q23). У 24 из 48 пациентов с MM (50%) определяли аномалии хромосомы 1. В группе из 21 больных с del(13q14) в 15 случаях имелись перестройки IgH Amp1q12;16. В то же время из 27 случаев без del(13q14) у 8 содержались Amp1q12; в 13 случаях отмечали перестройки IgH. Выявлена взаимосвязь между del(13q14) и Amp1q12(χ2 = 8,26, p < 0,01) и между del(13q14) и перестройками IgH (χ2 = 3,88, p < 0,05). Выводы: 13q делецию/моносомию 13, перестройку IGH и аномалию хромосомы 1 часто отмечают при MM, причем их распределение не случайно и тесно взаимосвязано. Интерфазный анализ FISH в комбинации с MACS с использованием CD138-специфичных антител является высокочувствительным методом детекции молекулярных цитогенетических аберраций при MM

Observation of Two New N* Peaks in J/psi -> ppi−nˉp pi^- \bar n and pˉπ+n\bar p\pi^+n Decays

The $\pi N$ system in decays of $J/\psi\to\bar NN\pi$ is limited to be isospin 1/2 by isospin conservation. This provides a big advantage in studying $N^*\to \pi N$ compared with $\pi N$ and $\gamma N$ experiments which mix isospin 1/2 and 3/2 for the $\pi N$ system. Using 58 million $J/\psi$ decays collected with the Beijing Electron Positron Collider, more than 100 thousand $J/\psi \to p \pi^- \bar n + c.c.$ events are obtained. Besides two well known $N^*$ peaks at 1500 MeV and 1670 MeV, there are two new, clear $N^*$ peaks in the $p\pi$ invariant mass spectrum around 1360 MeV and 2030 MeV. They are the first direct observation of the $N^*(1440)$ peak and a long-sought "missing" $N^*$ peak above 2 GeV in the $\pi N$ invariant mass spectrum. A simple Breit-Wigner fit gives the mass and width for the $N^*(1440)$ peak as $1358\pm 6 \pm 16$ MeV and $179\pm 26\pm 50$ MeV, and for the new $N^*$ peak above 2 GeV as $2068\pm 3^{+15}_{-40}$ MeV and $165\pm 14\pm 40$ MeV, respectively

Compression Deformation Behavior and Processing Map of Pure Copper

To reveal compression deformation behavior of pure copper, the deformation characteristics of pure copper have been investigated by means of compression tests in the temperature range of 400–900°C and strain rate range of 0.001–1 s⁻¹. The results show that the flow stress of pure copper increases with increasing strain rate and decreasing deformation temperature, which is characterized by work-hardening, dynamic recovery, dynamic recrystallization, and secondary work-hardening, etc. The activation energy of hot deformation is associated with deformation temperature and strain rate, and the average activation energy is calculated to be 303.8 kJ/mol. The flow stress prediction model based on GA+BP possess, is in very good agreement with the true stress curve, which is of significance to the guidance of hot working of pure copper. The flow instability occurs in the intermediate strain rate region (0.01–0.1 s⁻¹) base on the analysis of processing map, the high power dissipation correspond to the dynamic recrystallization. Appropriate reducing the deformation temperature or increasing the strain rate is beneficial for the grain refinement in the steady-state region of the processing map