683 research outputs found
Attracting East Asian Students to Canadian Graduate Schools
This study seeks to identify factors influencing East Asian international students’ choices of Canadian graduate schools, to assess the strengths and dynamics of the factors influencing enrolment decisions, and to describe possible implications both for the Canadian government and for Canadian universities offering graduate education. The research sample comprised 140 students from China, Hong Kong, Japan, Korea, and Taiwan who enrolled in graduate programs at two large Ontario universities. The research findings reveal the significant influence of academic, economic, environmental, and visa/immigration pulling factors as well as a set of negative pushing factors from third countries such as the United States. Activities related to internationalization of graduate education play a critical role in influencing the choice of a Canadian graduate school. The findings suggest that to attract the “best and brightest” international graduate students, policy makers and institutional administrators should focus on investing in research and ensuring the quality of graduate education while devoting efforts and resources to the internationalization of Canadian graduate education.Cet article porte sur la décision, par les étudiants internationaux de l’Asie orientale, d’étudier aux cycles supérieurs dans une université canadienne. L’étude cherche à identifier les facteurs infl uençant ce choix, à évaluer les forces et la dynamique des facteurs influençant la décision d’inscription, et à décrire des implications possibles pour le gouvernement canadien et pour les universités canadiennes. L’échantillon est composé de 140 étudiants originaires de Chine, de Hong Kong, du Japon, de Corée et de Taiwan qui s’étaient inscrits dans des programmes de cycle supérieur à deux grandes universités ontariennes. Les résultats de la recherche révèlent l’influence significative des facteurs académiques, économiques, environnementaux, et associés aux règles de l’immigration, ainsi qu’un ensemble de facteurs négatifs associés à des pays tiers tels que les États-Unis. Les activités faisant la promotion de l’internationalisation des cycles supérieurs jouent un rôle critique et influencent le choix d’une université canadienne à cet ordre d’enseignement. Les résultats suggèrent que, pour attirer les meilleurs étudiants internationaux aux cycles supérieurs, les décideurs gouvernementaux et les administrateurs institutionnels devraient investir dans la recherche et assurer la qualité de la formation aux cycles supérieurs, tout en consacrant efforts et ressources à l’internationalisation des programmes de cycles supérieurs au Canada
A QFD-Based Mathematical Model for New Product Development Considering the Target Market Segment
Responding to customer needs is important for business success. Quality function deployment provides systematic procedures for converting customer needs into technical requirements to ensure maximum customer satisfaction. The existing literature mainly focuses on the achievement of maximum customer satisfaction under a budgetary limit via mathematical models. The market goal of the new product for the target market segment is usually ignored. In this study, the proposed approach thus considers the target customer satisfaction degree for the target market segment in the model by formulating the overall customer satisfaction as a function of the quality level. In addition, the proposed approach emphasizes the cost-effectiveness concept in the design stage via the achievement of the target customer satisfaction degree using the minimal total cost. A numerical example is used to demonstrate the applicability of the proposed approach and its characteristics are discussed
Adhesive L1CAM-Robo Signaling Aligns Growth Cone F-Actin Dynamics to Promote Axon-Dendrite Fasciculation in C. elegans
Neurite fasciculation through contact-dependent signaling is important for the wiring and function of the neuronal circuits. Here, we describe a type of axon-dendrite fasciculation in C. elegans, where proximal dendrites of the nociceptor PVD adhere to the axon of the ALA interneuron. This axon-dendrite fasciculation is mediated by a previously uncharacterized adhesive signaling by the ALA membrane signal SAX-7/L1CAM and the PVD receptor SAX-3/Robo but independent of Slit. L1CAM physically interacts with Robo and instructs dendrite adhesion in a Robo-dependent manner. Fasciculation mediated by L1CAM-Robo signaling aligns F-actin dynamics in the dendrite growth cone and facilitates dynamic growth cone behaviors for efficient dendrite guidance. Disruption of PVD dendrite fasciculation impairs nociceptive mechanosensation and rhythmicity in body curvature, suggesting that dendrite fasciculation governs the functions of mechanosensory circuits. Our work elucidates the molecular mechanisms by which adhesive axon-dendrite signaling shapes the construction and function of sensory neuronal circuits
Depth, balancing, and limits of the Elo model
-Much work has been devoted to the computational complexity of games.
However, they are not necessarily relevant for estimating the complexity in
human terms. Therefore, human-centered measures have been proposed, e.g. the
depth. This paper discusses the depth of various games, extends it to a
continuous measure. We provide new depth results and present tool
(given-first-move, pie rule, size extension) for increasing it. We also use
these measures for analyzing games and opening moves in Y, NoGo, Killall Go,
and the effect of pie rules
Cell-free Circulating miRNA Biomarkers in Cancer.
Considerable attention and an enormous amount of resources have been dedicated to cancer biomarker discovery and validation. However, there are still a limited number of useful biomarkers available for clinical use. An ideal biomarker should be easily assayed with minimally invasive medical procedures but possess high sensitivity and specificity. Commonly used circulating biomarkers are proteins in serum, most of which require labor-intensive analysis hindered by low sensitivity in early tumor detection. Since the deregulation of microRNA (miRNA) is associated with cancer development and progression, profiling of circulating miRNAs has been used in a number of studies to identify novel minimally invasive miRNA biomarkers. In this review, we discuss the origin of the circulating cell-free miRNAs and their carriers in blood. We summarize the clinical use and function of potentially promising miRNA biomarkers in a variety of different cancers, along with their downstream target genes in tumor initiation and development. Additionally, we analyze some technical challenges in applying miRNA biomarkers to clinical practice
The Effectiveness of Traditional Chinese Medicine in Treating Patients with Leukemia
Leukemia is the most common malignancy among all childhood cancers and is associated with a low survival rate in adult patients. Since 1995, the National Health Insurance (NHI) program in Taiwan has been offering insurance coverage for Traditional Chinese Medicine (TCM), along with conventional Western medicine (WM). This study analyzes the status of TCM utilization in Taiwan, in both pediatric and adult patients with leukemia. A retrospective cohort study was conducted using population-based National Health Insurance Research Database of Registry of Catastrophic Illness, involving patient data from 2001 to 2010 and follow-up data through 2011. The effectiveness of TCM use was evaluated. Relevant sociodemographic data showed that both pediatric and adult patients who were TCM users one year prior to leukemia diagnosis were more likely to utilize TCM services for cancer therapy. A greater part of medical expenditure of TCM users was lower than that of TCM nonusers, except little discrepancy in drug fee of adult patients. The survival rate is also higher in TCM users. Altogether, these data show that TCM has the potential to serve as an adjuvant therapy when combined with conventional WM in the treatment of patients with leukemia
Optimization Study of Small-Scale Solar Membrane Distillation Desalination Systems (s-SMDDS)
[[abstract]]Membrane distillation (MD), which can utilize low-grade thermal energy, has been extensively studied for desalination. By incorporating solar thermal energy, the solar membrane distillation desalination system (SMDDS) is a potential technology for resolving energy and water resource problems. Small-scale SMDDS (s-SMDDS) is an attractive and viable option for the production of fresh water for small communities in remote arid areas. The minimum cost design and operation of s-SMDDS are determined by a systematic method, which involves a pseudo-steady-state approach for equipment sizing and dynamic optimization using overall system mathematical models. Two s-SMDDS employing an air gap membrane distillation module with membrane areas of 11.5 m2 and 23 m2 are analyzed. The lowest water production costs are 5.16/m3 for water production rates of 500 kg/day and 1000 kg/day, respectively. For these two optimal cases, the performance ratios are 0.85 and 0.91; the recovery ratios are 4.07% and 4.57%. The effect of membrane characteristics on the production cost is investigated. For the commercial membrane employed in this study, the increase of the membrane mass transfer coefficient up to two times is beneficial for cost reduction.[[notice]]補正完畢[[incitationindex]]SCI[[incitationindex]]EI[[booktype]]電子
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