95,584 research outputs found
Plerixafor alone for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells
An ACO Algorithm for Effective Cluster Head Selection
This paper presents an effective algorithm for selecting cluster heads in
mobile ad hoc networks using ant colony optimization. A cluster in an ad hoc
network consists of a cluster head and cluster members which are at one hop
away from the cluster head. The cluster head allocates the resources to its
cluster members. Clustering in MANET is done to reduce the communication
overhead and thereby increase the network performance. A MANET can have many
clusters in it. This paper presents an algorithm which is a combination of the
four main clustering schemes- the ID based clustering, connectivity based,
probability based and the weighted approach. An Ant colony optimization based
approach is used to minimize the number of clusters in MANET. This can also be
considered as a minimum dominating set problem in graph theory. The algorithm
considers various parameters like the number of nodes, the transmission range
etc. Experimental results show that the proposed algorithm is an effective
methodology for finding out the minimum number of cluster heads.Comment: 7 pages, 5 figures, International Journal of Advances in Information
Technology (JAIT); ISSN: 1798-2340; Academy Publishers, Finlan
Transcriptomic profiling and quantitative high-throughput (qHTS) drug screening of CDH1 deficient hereditary diffuse gastric cancer (HDGC) cells identify treatment leads for familial gastric cancer
Incremental eigenpair computation for graph Laplacian matrices: theory and applications
The smallest eigenvalues and the associated eigenvectors (i.e., eigenpairs) of a graph Laplacian matrix have been widely used for spectral clustering and community detection. However, in real-life applications, the number of clusters or communities (say, K) is generally unknown a priori. Consequently, the majority of the existing methods either choose K heuristically or they repeat the clustering method with different choices of K and accept the best clustering result. The first option, more often, yields suboptimal result, while the second option is computationally expensive. In this work, we propose an incremental method for constructing the eigenspectrum of the graph Laplacian matrix. This method leverages the eigenstructure of graph Laplacian matrix to obtain the Kth smallest eigenpair of the Laplacian matrix given a collection of all previously compute
The Expressive Power of Word Embeddings
We seek to better understand the difference in quality of the several
publicly released embeddings. We propose several tasks that help to distinguish
the characteristics of different embeddings. Our evaluation of sentiment
polarity and synonym/antonym relations shows that embeddings are able to
capture surprisingly nuanced semantics even in the absence of sentence
structure. Moreover, benchmarking the embeddings shows great variance in
quality and characteristics of the semantics captured by the tested embeddings.
Finally, we show the impact of varying the number of dimensions and the
resolution of each dimension on the effective useful features captured by the
embedding space. Our contributions highlight the importance of embeddings for
NLP tasks and the effect of their quality on the final results.Comment: submitted to ICML 2013, Deep Learning for Audio, Speech and Language
Processing Workshop. 8 pages, 8 figure
On Optimality of Myopic Sensing Policy with Imperfect Sensing in Multi-channel Opportunistic Access
We consider the channel access problem under imperfect sensing of channel
state in a multi-channel opportunistic communication system, where the state of
each channel evolves as an independent and identically distributed Markov
process. The considered problem can be cast into a restless multi-armed bandit
(RMAB) problem that is of fundamental importance in decision theory. It is
well-known that solving the RMAB problem is PSPACE-hard, with the optimal
policy usually intractable due to the exponential computation complexity. A
natural alternative is to consider the easily implementable myopic policy that
maximizes the immediate reward but ignores the impact of the current strategy
on the future reward. In this paper, we perform an analytical study on the
optimality of the myopic policy under imperfect sensing for the considered RMAB
problem. Specifically, for a family of generic and practically important
utility functions, we establish the closed-form conditions under which the
myopic policy is guaranteed to be optimal even under imperfect sensing. Despite
our focus on the opportunistic channel access, the obtained results are generic
in nature and are widely applicable in a wide range of engineering domains.Comment: 21 pages regular pape
On Optimality of Myopic Policy for Restless Multi-armed Bandit Problem with Non i.i.d. Arms and Imperfect Detection
We consider the channel access problem in a multi-channel opportunistic
communication system with imperfect channel sensing, where the state of each
channel evolves as a non independent and identically distributed Markov
process. This problem can be cast into a restless multi-armed bandit (RMAB)
problem that is intractable for its exponential computation complexity. A
natural alternative is to consider the easily implementable myopic policy that
maximizes the immediate reward but ignores the impact of the current strategy
on the future reward. In particular, we develop three axioms characterizing a
family of generic and practically important functions termed as -regular
functions which includes a wide spectrum of utility functions in engineering.
By pursuing a mathematical analysis based on the axioms, we establish a set of
closed-form structural conditions for the optimality of myopic policy.Comment: Second version, 16 page
Solubility improvement of progesterone from solid dispersions prepared by solvent evaporation and co-milling
The aim of this contribution was to evaluate the impact of processing methods and polymeric carriers on the physicochemical properties of solid dispersions of the poorly soluble drug progesterone (PG). Five polymers: hydroxypropyl methylcellulose (HPMC), hydroxypropyl methylcellulose acetate succinate (HPMCAS), microcrystalline cellulose (MCC), polyvinylpyrrolidone (PVP) and silica (SiO2), and two processing methods: solvent evaporation (SE) and mechano-chemical activation by co-milling (BM) were applied. H-bonding was demonstrated by FTIR spectra as clear shifting of drug peaks at 1707 cm−1 (C20 carbonyl) and 1668 cm−1 (C3 carbonyl). Additionally, spectroscopic and thermal analysis revealed the presence of unstable PG II polymorphic form and a second heating DSC cycle, the presence of another polymorph possibly assigned to form III, but their influence on drug solubility was not apparent. Except for PG–MCC, solid dispersions improved drug solubility compared to physical mixtures. For SE dispersions, an inverse relationship was found between drug water solubility and drug–polymer Hansen solubility parameter difference (∆δt), whereas for BM dispersions, the solubility was influenced by both the intermolecular interactions and the polymer Tg. Solubility improvement with SE was demonstrated for all except PG–MCC dispersions, whereas improvement with BM was demonstrated by the PG–HPMC, PG–PVP and PG–HPMCAS dispersions, the last showing impressive increase from 34.21 to 82.13 μg/mL. The extensive H-bonding between PG and HPMCAS was proved by FTIR analysis of the dispersion in the liquid state. In conclusion, although SE improved drug solubility, BM gave more than twice greater improvement. This indicates that directly operating intermolecular forces are more efficient than the solvent mediated
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