9,346 research outputs found

    Analysis of influencing factors of CO2 emissions based on different coal dependence zones in China

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    There are differences in economic level, population size, and technical level in different stages. At the same time, as a coal-dependent country, other regions have foreign dependence on coal. Then the primary factors and influence degrees of CO2 emissions in different stages and areas with different coal dependents will be various. This paper adds urbanization rate, industrial structure, and energy consumption structure to the traditional STIRPAT model. Based on the expanded STIRPAT model, the panel data of 30 regions in China from 2005 to 2019 are used to analyze the different stages and areas with foreign coal dependence. The main influencing factors and degree of influence of CO2 emissions. Regression finds that population size, energy consumption, and industrial structure will increase regional carbon dioxide emissions. There is an “inverted U-shaped” curve relationship between economic development, technological level, and carbon dioxide emissions. The improvement of the urbanization rate can reduce carbon dioxide emissions. Carbon dioxide emissions. An “inverted Ushaped” curve relationship between per capita GDP and CO2 emissions in three research periods from 2005 to 2010, 2011 to 2015, and 2016 to 2019. At the same time, the inhibition effect of the urbanization rate is constantly strengthened, and the promotion effect of the coal consumption ratio is decreasing year by year. The influence of population size, technical level, and industrial structure on carbon dioxide emissions in the whole country and areas with different coal dependents varies with the study period. To provide a theoretical basis for local conditions and regional management in the future direction of energy-saving and carbon reduction

    Destructive and Non-Destructive Testing of Bridge J857 Phelps County, Missouri : Feasibility Study on Damage Detection of RC Structures using Dynamic Signature Tests

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    This report presents the results of a research program aimed at investigating the constructability and effectiveness of externally bonded FRP strengthening systems for improving the flexural capacity of bridge decks and piers. The joint effort of two universities, industry, and a state DOT provided the premise for a successful outcome. Bridge J857 was constructed in 1932 and was scheduled for demolition in the fall of 1998 due to highway realignment. Two of the three solid reinforced concrete (RC) decks were strengthened using two FRP systems namely, near-surface mounted carbon FRP (CFRP) rods and surface bonded CFRP sheets. Bridge decks were tested to failure under quasi-static loading cycles. Flexural strengthening of bridge columns was achieved by mounting CFRP rods on two opposite sides of the columns. Columns were also jacketed with carbon and glass FRP laminates. The experimental moment capacities of the decks compared well with theoretical values. Strengthened decks exhibited ductile behavior prior to FRP failure. The columns were tested to failure by applying lateral load cycles. The proposed strengthening technique for the bridge columns is feasible and effective for improving the flexural capacity of RC columns. The capacity of the strengthened column sections could be predicted using classical methods of analysis. Dynamic tests were conducted on the deck strengthened with CFRP sheets. The objective of dynamic tests was to relate the change in fundamental frequency to the induced damage, which could be used as a tool to assess the damage level of RC structural members. An effective damage indicator was identified that requires no baseline for damage level detection

    Identification and profiling of microRNA between back and belly Skin in Rex rabbits (Oryctolagus cuniculus)

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    [EN] Skin is an important trait for Rex rabbits and skin development is influenced by many processes, including hair follicle cycling, keratinocyte differentiation and formation of coat colour and skin morphogenesis. We identified differentially expressed microRNAs (miRNAs) between the back and belly skin in Rex rabbits. In total, 211 miRNAs (90 upregulated miRNAs and 121 downregulated miRNAs) were identified with a |log2 (fold change)|>1 and P-value<0.05. Using target gene prediction for the miRNAs, differentially expressed predicted target genes were identified and the functional enrichment and signalling pathways of these target genes were processed to reveal their biological functions. A number of differentially expressed miRNAs were found to be involved in regulation of the cell cycle, skin epithelium differentiation, keratinocyte proliferation, hair follicle development and melanogenesis. In addition, target genes regulated by miRNAs play key roles in the activities of the Hedgehog signalling pathway, Wnt signalling pathway, Osteoclast differentiation and MAPK pathway, revealing mechanisms of skin development. Nine candidate miRNAs and 5 predicted target genes were selected for verification of their expression by quantitative reverse transcription polymerase chain reaction. A regulation network of miRNA and their target genes was constructed by analysing the GO enrichment and signalling pathways. Further studies should be carried out to validate the regulatory relationships between candidate miRNAs and their target genes.This study was supported by the Modern Agricultural Industrial System Special Funding (CARS-44-A-1), the Priority Academic Programme Development of Jiangsu Higher Education Institutions (2014-134) and the General Programme of Natural Science Foundation of the Higher Education Institutions of Jiangsu Province (16KJB230001).Zhao, B.; Chen, Y.; Mu, L.; Hu, S.; Wu, X. (2018). Identification and profiling of microRNA between back and belly Skin in Rex rabbits (Oryctolagus cuniculus). World Rabbit Science. 26(2):179-190. https://doi.org/10.4995/wrs.2018.7058SWORD179190262Adamidi C. 2008. Discovering microRNAs from deep sequencing data using miRDeep. Nature Biotechnol., 26: 407-415. https://doi.org/10.1038/nbt1394Adijanto J., Castorino J.J., Wang Z.X., Maminishkis A., Grunwald G.B., Philp N.J. 2012. Microphthalmia-associated transcription factor (MITF) promotes differentiation of human retinal pigment epithelium (RPE) by regulating microRNAs-204/211 expression. J. Biol. Chem., 287: 20491-https://doi.org/10.1074/jbc.M112.354761Ahmed M.I., Alam M., Emelianov V.U., Poterlowicz K., Patel A., Sharov A.A., Mardaryev A.N., Botchkareva N.V. 2014. MicroRNA-214 controls skin and hair follicle development by modulating the activity of the Wnt pathway. J. Cell Biol., 207: 549-567. https://doi.org/10.1083/jcb.201404001Alexander M., Kawahara G., Motohashi N., Casar J., Eisenberg I., Myers J., Gasperini M., Estrella E., Kho A., Mitsuhashi S. 2013. MicroRNA-199a is induced in dystrophic muscle and affects WNT signaling, cell proliferation, and myogenic differentiation. Cell Death Diff., 20: 1194-1208. https://doi.org/10.1038/cdd.2013.62Anders S. 2010. Analysing RNA-Seq data with the DESeq package. Mol. Biol., 43: 1-17.Andl T., Botchkareva N.V. 2015. MicroRNAs (miRNAs) in the control of HF development and cycling: the next frontiers in hair research. Exp. Dermatol., 24: 821-826. https://doi.org/10.1111/exd.12785Andl T., Reddy S.T., Gaddapara T., Millar S.E. 2002. WNT signals are required for the initiation of hair follicle development. Develop. Cell, 2: 643-653. https://doi.org/10.1016/S1534-5807(02)00167-3Antonini D., Russo MT., De Rosa L., Gorrese M., Del Vecchio L., Missero C. 2010. Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cells. J. Invest. Dermatol., 130: 1249-1257. https://doi.org/10.1038/jid.2009.438Athar M., Tang X., Lee J.L., Kopelovich L., Kim AL. 2006. Hedgehog signalling in skin development and cancer. Exp. Dermatol., 15: 667-677. https://doi.org/10.1111/j.1600-0625.2006.00473.xBartel D.P. 2004. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 116: 281-297.https://doi.org/10.1016/S0092-8674(04)00045-5Bashirullah A., Pasquinelli A.E., Kiger A.A., Perrimon N., Ruvkun G., Thummel C.S. 2003. Coordinate regulation of small temporal RNAs at the onset of Drosophila metamorphosis. Dev. Biol., 259: 1-8. https://doi.org/10.1016/S0012-1606(03)00063-0Bommer GT., Gerin I., Feng Y., Kaczorowski AJ., Kuick R., Love RE., Zhai Y., Giordano TJ., Qin ZS., Moore BB. 2007. p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr. Biol., 17: 1298-1307. https://doi.org/10.1016/j.cub.2007.06.068Braun C.J., Zhang X., Savelyeva I., Wolff S., Moll U.M., Schepeler T., Ørntoft T.F., Andersen C.L., Dobbelstein M. 2008. p53-Responsive micrornas 192 and 215 are capable of inducing cell cycle arrest. Cancer Res., 68: 10094-10104.https://doi.org/10.1158/0008-5472.CAN-08-1569Callis T.E., Chen J.F., Wang D.Z. 2007. MicroRNAs in skeletal and cardiac muscle development. Dna Cell Biol., 26: 219-225. https://doi.org/10.1089/dna.2006.0556Caramuta S., Egyházi S., Rodolfo M., Witten D., Hansson J., Larsson C., Lui W.O. 2010. MicroRNA expression profiles associated with mutational status and survival in malignant melanoma. J. Invest. Dermatol., 130: 2062-2070. https://doi.org/10.1038/jid.2010.63Chen C.H., Sakai Y., Demay M.B. 2001. Targeting expression of the human vitamin D receptor to the keratinocytes of vitamin D receptor null mice prevents alopecia. Endocrinology, 142: 5386-5386. https://doi.org/10.1210/endo.142.12.8650D'Juan T.F., Shariat N., Park C.Y., Liu H.J., Mavropoulos A., McManus M.T. 2013. Partially penetrant postnatal lethality of an epithelial specific MicroRNA in a mouse knockout. Plos One 8: e76634. https://doi.org/10.1371/journal.pone.0076634DeYoung M.P., Johannessen C.M., Leong C.O., Faquin W., Rocco J.W., Ellisen L.W. 2006. Tumor-specific p73 up-regulation mediates p63 dependence in squamous cell carcinoma. Cancer Res., 66: 9362-9368. https://doi.org/10.1158/0008-5472.CAN-06-1619Eckert R.L., Welter J.F. 1996. Transcription factor regulation of epidermal keratinocyte gene expression. Mol. Biol. Rep., 23: 59-70. https://doi.org/10.1007/BF00357073Enright A.J., Bino J., Ulrike G., Thomas T., Chris S., Marks D.S. 2004. MicroRNA targets in Drosophila. Gen. Biol., 5: R1-R1. https://doi.org/10.1186/gb-2003-5-1-r1Fontanesi L., Scotti E., Allain D., Dall'Olio S. 2014. A frameshift mutation in the melanophilin gene causes the dilute coat colour in rabbit (Oryctolagus cuniculus) breeds. Anim. Genet., 45: 248-255. https://doi.org/10.1111/age.12104Fontanesi L., Vargiolu M., Scotti E., Latorre R., Pellegrini M.S.F., Mazzoni M., Asti M., Chiocchetti R., Romeo G., Clavenzani P. 2014. The KIT gene is associated with the English spotting coat color locus and congenital megacolon in Checkered Giant rabbits (Oryctolagus cuniculus). Plos One 9: e93750. https://doi.org/10.1371/journal.pone.0093750Fuchs E. 2007. Scratching the surface of skin development. Nature, 445: 834-842. https://doi.org/10.1038/nature05659Georges S.A., Chau B.N., Braun C.J., Zhang X., Dobbelstein M. 2009. Cell cycle arrest or apoptosis by p53: are microRNAs-192/215 and-34 making the decision? Cell Cycle 8: 677-682. https://doi.org/10.4161/cc.8.5.8076Jackson S.J., Zhang Z., Feng D., Flagg M., O'Loughlin E., Wang D., Stokes N., Fuchs E., Yi R. 2013. Rapid and widespread suppression of self-renewal by microRNA-203 during epidermal differentiation. Development, 140: 1882-1891. https://doi.org/10.1242/dev.089649Katoh Y., Katoh M. 2008. Hedgehog signaling, epithelial-tomesenchymal transition and miRNA (review). Int. J. Mol. Med., 22: 271-275. https://doi.org/10.3892/ijmm_00000019Kim K., Vinayagam A., Perrimon N. 2014. A rapid genomewide microRNA screen identifies miR-14 as a modulator of Hedgehog signaling. Cell Rep., 7: 2066-2077. https://doi.org/10.1016/j.celrep.2014.05.025Kochegarov A., Moses A., Lian W., Meyer J., Hanna M.C., Lemanski L.F. 2013. A new unique form of microRNA from human heart, microRNA-499c, promotes myofibril formation and rescues cardiac development in mutant axolotl embryos. J. Biomed. Sci., 20: 1. https://doi.org/10.1186/1423-0127-20-20Kozomara, A., Griffiths J. 2014. miRBase: annotating high confidence microRNAs using deep sequencing data. Nucleic Acids Res., 42: 68-73. https://doi.org/10.1093/nar/gkt1181Kureel J., Dixit M., Tyagi A., Mansoori M., Srivastava K., Raghuvanshi A., Maurya R., Trivedi R., Goel A., Singh D. 2014. miR-542-3p suppresses osteoblast cell proliferation and differentiation, targets BMP-7 signaling and inhibits bone formation. Cell Death Dis., 5: e1050. https://doi.org/10.1038/cddis.2014.4Langmead B., Salzberg S.L. 2012. Fast gapped-read alignment with Bowtie 2. Nat. Methods, 9: 357-359. https://doi.org/10.1038/nmeth.1923Lim X., Nusse R. 2013. Wnt signaling in skin development, homeostasis, and disease. CSH Perspect. Biol., 5: a008029. https://doi.org/10.1101/cshperspect.a008029Liu Z., Xiao H., Li H., Zhao Y., Lai S., Yu X., Cai T., Du C., Zhang W., Li J. 2012. Identification of conserved and novel microRNAs in cashmere goat skin by deep sequencing. Plos One 7: e50001. https://doi.org/10.1371/journal.pone.0050001Mardaryev A.N., Ahmed M.I., Vlahov N.V., Fessing M.Y., Gill J.H., Sharov A.A., Botchkareva N.V. 2010. Micro-RNA-31 controls hair cycle-associated changes in gene expression programs of the skin and hair follicle. FASEB J. 24: 3869-3881. https://doi.org/10.1096/fj.10-160663Mills A.A., Zheng B., Wang X.J., Vogel H., Roop D.R., Bradley A. 1999. p63 is a p53 homologue required for limb and epidermal morphogenesis. Nature, 398: 708-713. https://doi.org/10.1038/19531Mueller D.W., Rehli M., Bosserhoff A.K. 2009. miRNA expression profiling in melanocytes and melanoma cell lines reveals miRNAs associated with formation and progression of malignant melanoma. J. Invest. Dermatol., 129: 1740-1751. https://doi.org/10.1038/jid.2008.452Naeem H., Küffner R., Csaba G., Zimmer R. 2010. miRSel: Automated extraction of associations between microRNAs and genes from the biomedical literature. Bmc Bioinformatics, 11: 135. https://doi.org/10.1186/1471-2105-11-135Neilson J.R., Zheng G.X., Burge CB., Sharp P.A. 2007. Dynamic regulation of miRNA expression in ordered stages of cellular development. Gene. Dev., 21: 578-589. https://doi.org/10.1101/gad.1522907Oda Y., Ishikawa M.H., Hawker N.P., Yun Q.C., Bikle D.D. 2007. Differential role of two VDR coactivators, DRIP205 and SRC-3, in keratinocyte proliferation and differentiation. J. Steroid Biochem., 103: 776-780. https://doi.org/10.1016/j.jsbmb.2006.12.069Pan L., Liu Y., Wei Q., Xiao C., Ji Q., Bao G., Wu X. 2015. Solexa-Sequencing Based Transcriptome Study of Plaice Skin Phenotype in Rex Rabbits (Oryctolagus cuniculus). Plos One: 10. https://doi.org/10.1371/journal.pone.0124583Rosenfield R.L., Deplewski D., Greene M.E. 2001. Peroxisome proliferator-activated receptors and skin development. Horm. Res. Paediat., 54: 269-274. https://doi.org/10.1159/000053270Schneider M.R. 2012. MicroRNAs as novel players in skin development, homeostasis and disease. Brit. J. Dermatol., 166: 22-28. https://doi.org/10.1111/j.1365-2133.2011.10568.xSenoo M., Pinto F., Crum C.P., McKeon F. 2007. p63 Is essential for the proliferative potential of stem cells in stratified epithelia. Cell, 129: 523-536. https://doi.org/10.1016/j.cell.2007.02.045Song B., Wang Y., Kudo K., Gavin E.J., Xi Y., Ju J. 2008. miR-192 Regulates dihydrofolate reductase and cellular proliferation through the p53-microRNA circuit. Clin. Cancer Res., 14: 8080-8086. https://doi.org/10.1158/1078-0432.CCR-08-1422Suh K.S., Mutoh M., Mutoh T., Li L., Ryscavage A., Crutchley J.M., Dumont R.A., Cheng C., Yuspa S.H. 2007. CLIC4 mediates and is required for Ca2+-induced keratinocyte differentiation. J. Cell Sci., 120: 2631-2640. https://doi.org/10.1242/jcs.002741Tao Y. 2010. Studies on the quality of rex rabbit fur. World Rabbit Sci., 2: 21-24. https://doi.org/10.4995/wrs.1994.213Tian X., Jiang J., Fan R., Wang H., Meng X., He X., He J., Li H., Geng J., Yu X. 2012. Identification and characterization of microRNAs in white and brown alpaca skin. BMC genomics 13: 1.https://doi.org/10.1186/1471-2164-13-555Vadlakonda L., Pasupuleti M., Pallu R. 2014. Role of PI3K-AKTmTOR and Wnt signaling pathways in transition of G1-S phase of cell cycle in cancer cells. Front. Oncol., 3: 85. https://doi.org/10.3389/fonc.2013.00085van Amerongen R., Fuerer C., Mizutani M., Nusse R. 2012. Wnt5a can both activate and repress Wnt/β-catenin signaling during mouse embryonic development. Dev. Biol., 369: 101-114. https://doi.org/10.1016/j.ydbio.2012.06.020Vousden K.H., Lane D.P. 2007. p53 in health and disease. Nat. Rev. Mol. Cell Biol., 8: 275-283. https://doi.org/10.1038/nrm2147Wang P., Li Y., Hong W., Zhen J., Ren J., Li Z., Xu A. 2012. The changes of microRNA expression profiles and tyrosinase related proteins in MITF knocked down melanocytes. Mol. BioSyst., 8: 2924-2931. https://doi.org/10.1039/c2mb25228gWhelan J.T., Hollis S.E., Cha D.S., Asch A.S., Lee M.H. 2012. Post‐transcriptional regulation of the Ras‐ERK/MAPK signaling pathway. J. Cell Physiol., 227: 1235-1241. https://doi.org/10.1002/jcp.22899Xia H., Ooi L.L.P.J., Hui K.M. 2013. MicroRNA-216a/217-induced epithelial-mesenchymal transition targets PTEN and SMAD7 to promote drug resistance and recurrence of liver cancer. Hepatology, 58: 629-641. https://doi.org/10.1002/hep.26369Yang A., Schweitzer R., Sun D., Kaghad M., Walker N., Bronson R.T., Tabin C., Sharpe A., Caput D., Crum C. 1999. p63 is essential for regenerative proliferation in limb, craniofacial and epithelial development. Nature, 398: 714-718. https://doi.org/10.1038/19539Yu J., Peng H., Ruan Q., Fatima A., Getsios S., Lavker R.M. 2010. MicroRNA-205 promotes keratinocyte migration via the lipid phosphatase SHIP2. FASEB J. 24: 3950-3959. https://doi.org/10.1096/fj.10-157404Yu J., Ryan D.G., Getsios S., Oliveira-Fernandes M., Fatima A., Lavker R.M. 2008. MicroRNA-184 antagonizes microRNA-205 to maintain SHIP2 levels in epithelia. In Proc.: National Academy of Sciences 105: 19300-19305. https://doi.org/10.1073/pnas.0803992105Zhang L., Nie Q., Su Y., Xie X., Luo W., Jia X., Zhang X. 2013. MicroRNA profile analysis on duck feather follicle and skin with high-throughput sequencing technology. Gene, 519: 77-81. https://doi.org/10.1016/j.gene.2013.01.043Zhao Y., Wang P., Meng J., Ji Y., Xu D., Chen T., Fan R., Yu X., Yao J., Dong C. 2015. MicroRNA-27a-3p Inhibits Melanogenesis in Mouse Skin Melanocytes by Targeting Wnt3a. Int. J. Mol. Sci., 16: 10921-10933. https://doi.org/10.3390/ijms16051092

    A Cheaper and Better Diffusion Language Model with Soft-Masked Noise

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    Diffusion models that are based on iterative denoising have been recently proposed and leveraged in various generation tasks like image generation. Whereas, as a way inherently built for continuous data, existing diffusion models still have some limitations in modeling discrete data, e.g., languages. For example, the generally used Gaussian noise can not handle the discrete corruption well, and the objectives in continuous spaces fail to be stable for textual data in the diffusion process especially when the dimension is high. To alleviate these issues, we introduce a novel diffusion model for language modeling, Masked-Diffuse LM, with lower training cost and better performances, inspired by linguistic features in languages. Specifically, we design a linguistic-informed forward process which adds corruptions to the text through strategically soft-masking to better noise the textual data. Also, we directly predict the categorical distribution with cross-entropy loss function in every diffusion step to connect the continuous space and discrete space in a more efficient and straightforward way. Through experiments on 5 controlled generation tasks, we demonstrate that our Masked-Diffuse LM can achieve better generation quality than the state-of-the-art diffusion models with better efficiency.Comment: Code is available at https://github.com/amazon-science/masked-diffusion-l

    Analytical behaviour of concrete-encased CFST box stub columns under axial compression

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    [EN] Concrete-encased CFST (concrete-filled steel tube) members have been widely used in high-rise buildings and bridge structures. In this paper, the axial performance of a typical concrete-encased CFST box member with inner CFST and outer reinforced concrete (RC) is investigated. A finite element analysis (FEA) model is established to analyze the compressive behavior of the composite member. The material nonlinearity and the interaction between concrete and steel tube are considered. A good agreement is achieved between the measured and predicted results in terms of the failure mode and the load-deformation relation. The verified FEA model is then used to conduct the full range analysis on the load versus deformation relations. The loading distributions of different components inclouding concrete, steel tube and longitudinal bar during four stages are discussed. Typical failure modes, internal force distribution, stress development and the contact stress between concrete and steel tube are also presented. The parametric study on the compressive behavior is conducted to investigate the effects of various parameters, e.g. the strength of concrete and steel, longitudinal bar ratio and stirrup space on the sectional capacity and the ductility of the concrete-encased CSFT box member.Chen, J.; Han, L.; Wang, F.; Mu, T. (2018). Analytical behaviour of concrete-encased CFST box stub columns under axial compression. En Proceedings of the 12th International Conference on Advances in Steel-Concrete Composite Structures. ASCCS 2018. Editorial Universitat Politècnica de València. 401-408. https://doi.org/10.4995/ASCCS2018.2018.6966OCS40140

    The relationship between velocity utilization rate and pole vault performance

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    In the pole vault event, the velocity of approach is a highly vital factor. As velocity of approach improvements highly impact performance improvements. This study analysed the relationships between sprint running’s speed (SR), pole running (PR, without jump), and the pole vault approach (PVA, with real jump). Analysed too were the relationships between both the approach and performance’s respective running distance, velocity, and velocity utilization rates. Methods: Ten male pole vaulters were recruited. Measured was each 5-meter segment’s average velocity of his respective SR, PR, and PVA, along with the distance to maximum velocity. Results: The maximum average velocity of the PR’s 5m segments altogether was significantly positively correlated with pole vault (PV) performance; The maximum average velocity of the PR’s 5m segments altogether was significantly positively correlated with the last 5m PVA average velocity; The PVA velocity’s utilization rate was significantly negatively correlated with the difference between the distance to the PR’s maximum velocity and the PVA’s distance. Conclusion: The PR segment’s maximum speed capability can evaluate both a pole vaulter’s potential and pole vault-specific abilities. This study’s recruited pole vaulters’ respective approach distances were generally insufficient that resulted in a lower velocity utilization rate. Suggested is that in training, the pole vaulter could first find the distance required to reach the highest velocity upon starting from the PR test. Thus, this subsequently known distance could be applied in tandem with the pole vault’s approach to both improve the PVA’s utilization rate and reach the individual highest speed level
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