Energy saving potential of a counter-flow regenerative evaporative cooler for various climates of China: Experiment-based evaluation

© 2017 Recently there has been growing interest in regenerative evaporative coolers (REC), which can reduce the temperature of the supply air to below the wet-bulb of intake air and approach its dew-point. In this paper, we designed, fabricated and experimentally tested a counter-flow REC in laboratory. The REC's core heat and mass exchanger was fabricated using stacked sheets composed of high wicking evaporation (wickability of available materials was measured) and waterproof aluminium materials. The developed REC system has a much higher cooling performance compared to conventional indirect evaporative cooler. However, the decision to use the REC for China buildings depends on a dedicated evaluation of the net energy saved against the capital expended. Such an evaluation requires the hourly-based data on the availability of cooling capacity provided by the REC for various climates. The paper used an experiment-based method to estimate the cooling capacity and energy savings provided by the proposed REC for China's various climates. By using the experimental results and regional hourly-based weather data, the energy saving potential of the REC against an equivalent-sized mechanical air conditioner alone was analysed. The results indicate that, for all selected regions, the REC could reduce 53–100% of cooling load and 13–58% of electrical energy consumption annually

Experimental Study on the Energy Performance of PV-HP Water Heating System

AbstractMany studies have found that the decrease of photovoltaic (PV) cell temperature would increase the solar-to-electricity conversion efficiency. This paper provided a study on the thermal and electrical performance of PV panel with active cooling by attaching heat pipes beneath the PV panel, building up a PV-heat pipe (HP) combined system. The effect of solar radiation, inlet water temperature and water flow on the electrical and thermal efficiencies of the system were studied. The results showed that the thermal efficiency of the heat pipe PV/thermal (PV/T) solar water heating system decreased with the increasing inlet water temperature and water flow, and increased with the increasing solar radiation; the electrical efficiency decreased with increasing solar radiation, inlet water temperature and water flow

Numerical investigation of the energy performance of a guideless irregular heat and mass exchanger with corrugated heat transfer surface for dew point cooling

© 2016 The Author(s) The paper presents an investigation into the energy performance of a novel irregular heat and mass exchanger for dew point cooling which, compared to the existing flat-plate heat exchangers, removed the use of the channel supporting guides and implemented the corrugated heat transfer surface, thus expecting to achieve the reduced air flow resistance, increased heat transfer area, and improved energy efficiency (i.e. Coefficient of Performance (COP)) of the air cooling process. CFD simulation was carried out to determine the flow resistance (K) factors of various elements within the dry and wet channels of the exchanger, while the ‘finite-element’ based ‘Newton-iteration’ numerical simulation was undertaken to investigate its cooling capacity, cooling effectiveness and COP at various geometrical and operational conditions. Compared to the existing flat-plate heat and mass exchangers with the same geometrical dimensions and operational conditions, the new irregular exchanger could achieve 32.9%–37% higher cooling capacity, dew-point and wet-bulb effectiveness, 29.7%–33.3% higher COP, and 55.8%–56.2% lower pressure drop. While undertaking dew point air cooling, the irregular heat and mass exchanger had the optimum air velocity of 1 m/s within the flow channels and working-to-intake air ratio of 0.3, which allowed the highest cooling capacity and COP to be achieved. In terms of the exchanger dimensions, the optimum height of the channel was 5 mm while its length was in the range 1–2 m. Overall, the proposed irregular heat and mass exchanger could lead to significant enhanced energy performance compared to the existing flat-plate dew point cooling heat exchanger of the same geometrical dimensions. To achieve the same amount cooling output, the irregular heat and mass exchanger had the reduced size and cost against the flat-plate ones

Phosphorylation of Shox2 Is Required for Its Function to Control Sinoatrial Node Formation

Background: Inactivation of Shox2, a member of the short‐stature homeobox gene family, leads to defective development of multiple organs and embryonic lethality as a result of cardiovascular defects, including bradycardia and severe hypoplastic sinoatrial node (SAN) and sinus valves, in mice. It has been demonstrated that Shox2 regulates a genetic network through the repression of Nkx2.5 to maintain the fate of the SAN cells. However, the functional mechanism of Shox2 protein as a transcriptional repressor on Nkx2.5 expression remains completely unknown. Methods and Results: A specific interaction between the B56δ regulatory subunit of PP2A and Shox2a, the isoform that is expressed in the developing heart, was demonstrated by yeast 2‐hybrid screen and coimmunoprecipitation. Western blotting and immunohistochemical assays further confirmed the presence of phosphorylated Shox2a (p‐Shox2a) in cell culture as well as in the developing mouse and human SAN. Site‐directed mutagenesis and in vitro kinase assays identified Ser92 and Ser110 as true phosphorylation sites and substrates of extracellular signal‐regulated kinase 1 and 2. Despite that Shox2a and its phosphorylation mutants possessed similar transcriptional repressive activities in cell cultures when fused with Gal4 protein, the mutant forms exhibited a compromised repressive effect on the activity of the mouse Nkx2.5 promoter in cell cultures, indicating that phosphorylation is required for Shox2a to repress Nkx2.5 expression specifically. Transgenic expression of Shox2a, but not Shox2a‐S92AS110A, mutant in the developing heart resulted in down‐regulation of Nkx2.5 in wild‐type mice and rescued the SAN defects in the Shox2 mutant background. Last, we demonstrated that elimination of both phosphorylation sites on Shox2a did not alter its nuclear location and dimerization, but depleted its capability to bind to the consensus sequences within the Nkx2.5 promoter region. Conclusions: Our studies reveal that phosphorylation is essential for Shox2a to repress Nkx2.5 expression during SAN development and differentiation

Observation on the Curative Effect of Madopar Combined with Pramipexole in the Treatment of Parkinson’s Diseases

Parkinson’s disease is a common neurological degenerative disease in the elderly. The clinical manifestations are static tremor, increased muscle tone, slow movement, abnormal posture gait, and severe symptoms of loss of self-care. Parkinson’s disease has become a burden to not only patient, but also to his family and to the society. Normal human brain neurotransmitter dopamine and acetylcholine are in a balanced state, the two antagonism can maintain normal body function. The pathological changes of patients with Parkinson’s disease is degeneration and apoptosis of dopaminergic neurons in striatum, resulting in a significant reduction in dopamine levels, and thus lead to an imbalance in the effects of dopamine and acetylcholine, and a decrease in dopamine resistance to acetylcholine Parkinson’s disease symptoms. As such, this article will focus on the analysis of the Madopar and pramipexole in the treatment of Parkinson’s disease symptoms

Quantification of gas hydrate saturation and morphology based on a generalized effective medium model

Highlights • A modified cementation theory is developed by introducing generalized pressure-dependent normalized contact-cemented radii. • A generalized effective medium model is proposed to merge the effective medium theory and cementation theory. • Modeling and inversion schemes are proposed to quantify hydrate saturation and morphology from laboratory and well-log data. • Hydrates mainly grow as matrix-supporting form (~54%) in sands and as pore-filling form (~59%) in clay-rich marine sediments. Abstract Numerous models have been developed for prediction of gas hydrate saturation based on the microstructural relationship between gas hydrates and sediment grains. However, quantification of hydrate saturation and morphology from elastic properties has been hindered by failing to account for complex hydrate distributions. Here, we develop a generalized effective medium model by applying the modified Hashin-Shtrikman bounds to a newly developed cementation theory. This model is validated by experimental data for synthetic methane and tetrahydrofuran hydrates. Good comparison of model predictions with experimental measurements not only reveals its ability to merge the results of contact cementation theory and effective medium theory, but also indicates its feasibility for characterizing complex morphologies. Moreover, the results of inverting acoustic measurements quantitatively confirm that for synthetic samples in “excess-gas” condition gas hydrates mainly occur as a hybrid-cementing morphology with a low percentage of pore-filling morphology, whereas for pressure-core hydrate-bearing sediments in natural environments they exist as matrix-supporting and pore-filling morphologies with a very low percentage of hybrid-cementing morphology. The hydrate saturations estimated from sonic and density logs in several regions including northern Cascadia margin (Integrated Ocean Drilling Program Expedition 311, Hole U1326D and Hole U1327E), Alaska North Slope (Mount Elbert test well) and Mackenzie Delta (Mallik 5L-38), are comparable to the referenced hydrate saturations derived from core data and resistivity, and/or nuclear magnetic resonance log data, confirming validity and applicability of our model. Furthermore, our results indicate that ~8% hybrid-cementing, ~33% matrix-supporting and ~59% pore-filling hydrates may coexist in the fine-grained and clay-rich marine sediments on the northern Cascadia margin, whereas ~10% hybrid-cementing, ~54% matrix-supporting and ~36% pore-filling hydrates may coexist in the coarse-grained and sand-dominated terrestrial sediments of the Alaska North Slope and Mackenzie Delta