Dichloridobis[ethyl 2-(2-amino-1,3-thia­zol-4-yl)acetate-κ2 O,N 3]cadmium

The asymmetric unit of the title compound, [CdCl2(C7H10N2O2S)2], contains two complex molecules with similar configurations. The CdII atoms are each six-coordinated by two thiazole N and two carbonyl O atoms from the 2-(2-amino-1,3-thiazol-4-yl)acetate ligand, and by two Cl− anions in a distorted octa­hedral geometry. In the crystal, intra- and inter­molecular N—H⋯Cl hydrogen bonds create parallel chains along [1-10]. C—H⋯Cl inter­actions also occur

cis-Aqua­bis(2,4-dichloro-6-formyl­phenolato-κ2 O,O′)(N,N-dimethyl­formamide-κO)nickel(II)

In the title compound, [Ni(C7H3Cl2O2)2(C3H7NO)(H2O)], the NiII ion is coordinated by four O atoms from two bidentate 2,4-dichloro-6-formyl­phenolate ligands, one O atom from a water ligand and one O atom from a dimethyl­formamide ligand in a slightly distorted octa­hedral environment. In the crystal structure, centrosymmetric dimers are formed though O—H⋯O and O—H⋯Cl hydrogen bonds; π–π stacking inter­actions, with a centroid–centroid distance of 3.796 (2) Å, are also found

(Z)-Isobutyl 2-benzamido-3-(4-chloro­phen­yl)acrylate

The title compound, C20H20ClNO3, is a α-amino acid derivative which displays a Z configuration about the C=C double bond. The dihedral angle betwen the aromatic rings is 87.75 (12)°. The mol­ecular conformation is stabilized by an intra­molecular C—H⋯N hydrogen bond. In the crystal structure, centrosymmetrically related mol­ecules inter­act through inter­molecular C—H⋯O hydrogen-bond inter­actions, forming dimers. The dimers are further linked into chains parallel to the a axis by N—H⋯O hydrogen bonds. The methyl groups of the isopropyl group are disordered over two positions with occupancy factors of 0.5

Rhodiola crenulata extract for prevention of acute mountain sickness: a randomized, double-blind, placebo-controlled, crossover trial

BACKGROUND: Rhodiola crenulata (R. crenulata) is widely used to prevent acute mountain sickness in the Himalayan areas and in Tibet, but no scientific studies have previously examined its effectiveness. We conducted a randomized, double-blind, placebo-controlled crossover study to investigate its efficacy in acute mountain sickness prevention. METHODS: Healthy adult volunteers were randomized to 2 treatment sequences, receiving either 800 mg R. crenulata extract or placebo daily for 7 days before ascent and 2 days during mountaineering, before crossing over to the alternate treatment after a 3-month wash-out period. Participants ascended rapidly from 250 m to 3421 m on two separate occasions: December 2010 and April 2011. The primary outcome measure was the incidence of acute mountain sickness, as defined by a Lake Louise score ≥ 3, with headache and at least one of the symptoms of nausea or vomiting, fatigue, dizziness, or difficulty sleeping. RESULTS: One hundred and two participants completed the trial. There were no demographic differences between individuals taking Rhodiola-placebo and those taking placebo-Rhodiola. No significant differences in the incidence of acute mountain sickness were found between R. crenulata extract and placebo groups (all 60.8%; adjusted odds ratio (AOR) = 1.02, 95% confidence interval (CI) = 0.69–1.52). The incidence of severe acute mountain sickness in Rhodiola extract vs. placebo groups was 35.3% vs. 29.4% (AOR = 1.42, 95% CI = 0.90–2.25). CONCLUSIONS: R. crenulata extract was not effective in reducing the incidence or severity of acute mountain sickness as compared to placebo. TRIAL REGISTRATION: ClinicalTrials.gov NCT01536288

Peculiar optical properties of bilayer silicene under the influence of external electric and magnetic fields

We conduct a comprehensive investigation of the effect of an applied electric field on the optical and magneto-optical absorption spectra for AB-bt (bottom-top) bilayer silicene. The generalized tightbinding model in conjunction with the Kubo formula is efficiently employed in the numerical calculations. The electronic and optical properties are greatly diversified by the buckled lattice structure, stacking configuration, intralayer and interlayer hopping interactions, spin-orbital couplings, as well as the electric and magnetic fields (Ez ˆz & Bz ˆz ). An electric field induces spin-split electronic states, a semiconductor-metal phase transitions and the Dirac cone formations in different valleys, leading to the special absorption features. The Ez-dependent low-lying Landau levels possess lower degeneracy, valley-created localization centers, peculiar distributions of quantum numbers, well-behaved and abnormal energy spectra in Bz-dependencies, and the absence of anti-crossing behavior. Consequently, the specific magneto-optical selection rules exist for diverse excitation categories under certain critical electric fields. The optical gaps are reduced as Ez is increased, but enhanced by Bz, in which the threshold channel might dramatically change in the former case. These characteristics are in sharp contrast with those for layered graphene

Molecular cloning, expression pattern of Trypsin gene and association analysis with growth traits in Penaeus monodon

A novel TRY homolog was cloned in Penaeus monodon by RACE technology, named PmTry (GenBank: KP998480). The PmTry cDNA was 916 bp, which encodes 266 amino acids with a predicted molecular weight of 28.38 KDa and an isoelectric point of 4.58. Homologous analysis indicated that PmTry shared 42%~91% similarity with other species. The phylogenetic tree showed that PmTry was closely related to Fenneropenaeus chinensis. Tissue expression profiles showed that PmTry was highest expressed in the hepatopancreas and the lowest expressed in the eyestalk nerve. It was expressed in the whole growth stage of P. monodon, but the relative expression level of each stage was significantly different. In addition, PmTry-524 and PmTry-798 were particularly related to growth traits of P. monodon by genotype. The SNP markers may provide a basis for genetic selection and breed improvement studies in P. monodon

Implementasi Model Pola Asuh Orangtua Untuk Meningkatkan Kemandirian Anak

Penelitian ini mengkaji implementasi Model Pola Asuh Orangtua untuk Meningkatkan Kemandirian Anak (PAO-MKA) di SMP Makassar. Model PAO-MKA dikembangkan oleh Sunarty (2014), dan telah melalui uji validitas ahli dan praktisi/Guru BK, dan hasilnya valid, dan siap diimplemantasikan. Permasalahan penelitian adalah apakah Model PAO-MKA efektif meningkatkan kemandirian anak?. Tujuan penelitian adalah untuk mengetahui keefektifan Model PAO-MKA dalam upaya meningkatkan kemandirian anak. Penelitian ini menggunakan pendekatan kuantitatif, dengan jenis penelitian pra-experimental, model one group pretest-posttes design. Eksperimen dilaksanakan di SMPN 8 Makassar. Subyek penelitian terbagi ke dalam dua kelompok, yakni kelompok anak dan orangtuanya, masing-masing berjumlah 30 orang. Subyek anak diperlukan dalam kaitannya dengan pengukuran tingkat kemandirian anak. Sementara subyek orangtua diperlukan dalam kaitannya dengan implementasi Model PAO-MKA. Data dianalisis dengan uji statistik inferensial, yakni uji t atau uji perbedaan mean. Hasil penelitian menunjukkan bahwa terdapat perbedaan yang positif dan signifikan antara tingkat kemandirian anak sebelum (pretest) dan sesudah (posttest) pelatihan dan penerapan model PAO-MKA. Dengan adanya perbedaan tersebut maka Model PAO-MKA dinyatakan efektif meningkatkan kemandirian anak

Tumor-released autophagosomes induces CD4

BACKGROUND: CD4 METHODS: TRAPs isolated from tumor cell lines and pleural effusions or ascites of cancer patients were incubated with CD4 RESULTS: Heat shock protein 90α (HSP90α) on the surface of TRAPs from malignant effusions of cancer patients and tumor cell lines stimulated CD4 CONCLUSIONS: HSP90α on the surface of TRAPs programs the immunosuppressive functions of CD

Exercise intervention improves mitochondrial quality in non-alcoholic fatty liver disease zebrafish

IntroductionRecent reports indicate that mitochondrial quality decreases during non-alcoholic fatty liver disease (NAFLD) progression, and targeting the mitochondria may be a possible treatment for NAFLD. Exercise can effectively slow NAFLD progression or treat NAFLD. However, the effect of exercise on mitochondrial quality in NAFLD has not yet been established.MethodsIn the present study, we fed zebrafish a high-fat diet to model NAFLD, and subjected the zebrafish to swimming exercise.ResultsAfter 12 weeks, swimming exercise significantly reduced high-fat diet-induced liver injury, and reduced inflammation and fibrosis markers. Swimming exercise improved mitochondrial morphology and dynamics, inducing upregulation of optic atrophy 1(OPA1), dynamin related protein 1 (DRP1), and mitofusin 2 (MFN2) protein expression. Swimming exercise also activated mitochondrial biogenesis via the sirtuin 1 (SIRT1)/ AMP-activated protein kinase (AMPK)/ PPARgamma coactivator 1 alpha (PGC1α) pathway, and improved the mRNA expression of genes related to mitochondrial fatty acid oxidation and oxidative phosphorylation. Furthermore, we find that mitophagy was suppressed in NAFLD zebrafish liver with the decreased numbers of mitophagosomes, the inhibition of PTEN-induced kinase 1 (PINK1) – parkin RBR E3 ubiquitin protein ligase (PARKIN) pathway and upregulation of sequestosome 1 (P62) expression. Notably, swimming exercise partially recovered number of mitophagosomes, which was associated with upregulated PARKIN expression and decreased p62 expression.DiscussionThese results demonstrate that swimming exercise could alleviate the effects of NAFLD on the mitochondria, suggesting that exercise may be beneficial for treating NAFLD

A simulation study on the measurement of D0-D0bar mixing parameter y at BES-III

We established a method on measuring the \dzdzb mixing parameter $y$ for BESIII experiment at the BEPCII $e^+e^-$ collider. In this method, the doubly tagged $\psi(3770) \to D^0 \overline{D^0}$ events, with one $D$ decays to CP-eigenstates and the other $D$ decays semileptonically, are used to reconstruct the signals. Since this analysis requires good $e/\pi$ separation, a likelihood approach, which combines the $dE/dx$, time of flight and the electromagnetic shower detectors information, is used for particle identification. We estimate the sensitivity of the measurement of $y$ to be 0.007 based on a $20fb^{-1}$ fully simulated MC sample.Comment: 6 pages, 7 figure