A framework of web-based conceptual design

A web-based conceptual design prototype system is presented. The system consists of four parts which interpret on-line sketches as 2D and 3D geometry, extract 3D hierarchical configurations, allow editing of component behaviours, and produce VRML-based behavioural simulations for design verification and web-based application. In the first part, on-line freehand sketched input is interpreted as 2D and 3D geometry, which geometrically represents conceptual design. The system then infers 3D configuration by analysing 3D modelling history. The configuration is described by a parent–child hierarchical relationship and relative positions between two geometric components. The positioning information is computed with respect to the VRML97 specification. In order to verify the conceptual design of a product, the behaviours can be specified interactively on different components. Finally, the system creates VRML97 formatted files for behavioural simulation and collaborative design application over the Internet. The paper gives examples of web-based applications. This work forms a part of a research project into the design and establishing of modular machines for automation manufacture. A consortium of leading automotive companies is collaborating on the research project

Intravenous omega-3, a technique to prevent an excessive innate immune response to cardiac surgery in a rodent gut ischemia model

ObjectivesNeutrophil infiltration of tissues as part of the inflammatory response to cardiac surgery is one of the major mediators of postoperative multiple-organ dysfunction. Omega-3 fatty acids markedly attenuate endothelial cell inflammatory responses, including upregulation of neutrophil adhesion molecules. The efficacy of a clinically safe form of omega-3 to produce this effect in vivo was examined.MethodsRat gut intravital microscopic analysis was used to visualize neutrophil transmigration from the microcirculation into the tissues of the gut. Inflammatory activation was in the form of 30 minutes of ischemia and 90 minutes of reperfusion. Sham, control (0.9% saline infusion over 4 hours), and omega-3 (Omegaven [Fresenius Kabi, Bad Homburg, Germany] infusion over 4 hours) pretreatments were compared.ResultsIschemia–reperfusion resulted in a 4-fold increase in neutrophil adherence to the endothelium (baseline: 4.3 ± 0.2 vs control group: 19.2 ± 3.5 adherent neutrophils per 100 μm, P < .01), which intravenous omega-3 suppressed (7.8 ± 1.7 adherent neutrophils per 100 μm, P < .01). Omega-3 pretreatment also reduced neutrophil transmigration into the tissues after reperfusion (sham group: 6.3 ± 0.8 vs control group: 13.2 ± 1.4 vs omega-3 group: 9.4 ± 0.9 neutrophils per field, P = .037). Gut tissue levels of the neutrophil-released enzyme myeloperoxidase were similarly markedly reduced with omega-3 pretreatment (sham group: 10.5 ± 1.6 vs control group: 19.0 ± 3.3 vs omega-3 group: 10.1 ± 1.2 U/g, P = .03).ConclusionsFour hours' pretreatment with a relatively safe form of intravenous omega-3 suppressed neutrophil adherence and tissue infiltration, resulting in lower levels of the tissue-damaging enzyme myeloperoxidase. This suggests a possible strategy for diminishing postoperative multiple-organ dysfunction

Enhancement of process capabilities in electrically-assisted double sided incremental forming

© 2015 Elsevier Ltd. Electrically-assisted incremental sheet forming (E-ISF) is an effective method to improve formability by introducing the electric current in ISF process. This method is particularly useful for production of lightweight 'hard-to-form' materials such as magnesium and titanium alloys. However, the use of electricity and heat may also lead to side effects to formed components, such as unacceptable surface finish. In this work, an improved E-DSIF process has been developed by combining the electrically-assisted forming technology, the double sided incremental forming (DSIF) and a newly designed slave tool force control device to ensure stable tool-sheet contact. Different types of forming tools and toolpath strategies are explored to improve surface finish and geometrical accuracy by using a customized DSIF machine. AZ31B magnesium alloy sheets are formed into a truncated cone shape to verify the proposed E-DSIF process. In the investigation, the causes of rough surface finish are investigated in detail, and the surface finish is refined by improving the contact condition at tool-sheet interface. In addition, a hybrid toolpath strategy is proposed to further enhance the geometrical accuracy. The results demonstrate that the two challenging issues, surface finish and geometrical accuracy, could be improved by using the enhanced technologies of E-DSIF

Magnetic Coherence in Cuprate Superconductors

Recent inelastic neutron scattering (INS) experiments on La$_{2-x}$Sr$_x$CuO$_4$ observed a {\it magnetic coherence effect}, i.e., strong frequency and momentum dependent changes of the spin susceptibility, $\chi''$, in the superconducting phase. We show that this effect is a direct consequence of changes in the damping of incommensurate antiferromagnetic spin fluctuations due to the appearance of a d-wave gap in the fermionic spectrum. Our theoretical results provide a quantitative explanation for the weak momentum dependence of the observed spin-gap. Moreover, we predict {\bf (a)} a Fermi surface in La$_{2-x}$Sr$_x$CuO$_4$ which is closed around $(\pi,\pi)$ up to optimal doping, and {\bf (b)} similar changes in $\chi''$ for all cuprates with an incommensurate magnetic response.Comment: 5 pages, 4 figures, Fig.3 is in colo

Exactly solvable model of quantum diffusion

We study the transport property of diffusion in a finite translationally invariant quantum subsystem described by a tight-binding Hamiltonian with a single energy band and interacting with its environment by a coupling in terms of correlation functions which are delta-correlated in space and time. For weak coupling, the time evolution of the subsystem density matrix is ruled by a quantum master equation of Lindblad type. Thanks to the invariance under spatial translations, we can apply the Bloch theorem to the subsystem density matrix and exactly diagonalize the time evolution superoperator to obtain the complete spectrum of its eigenvalues, which fully describe the relaxation to equilibrium. Above a critical coupling which is inversely proportional to the size of the subsystem, the spectrum at given wavenumber contains an isolated eigenvalue describing diffusion. The other eigenvalues rule the decay of the populations and quantum coherences with decay rates which are proportional to the intensity of the environmental noise. On the other hand, an analytical expression is obtained for the dispersion relation of diffusion. The diffusion coefficient is proportional to the square of the width of the energy band and inversely proportional to the intensity of the environmental noise because diffusion results from the perturbation of quantum tunneling by the environmental fluctuations in this model. Diffusion disappears below the critical coupling.Comment: Submitted to J. Stat. Phy

Hydrophobic and ionic-interactions in bulk and confined water with implications for collapse and folding of proteins

Water and water-mediated interactions determine thermodynamic and kinetics of protein folding, protein aggregation and self-assembly in confined spaces. To obtain insights into the role of water in the context of folding problems, we describe computer simulations of a few related model systems. The dynamics of collapse of eicosane shows that upon expulsion of water the linear hydrocarbon chain adopts an ordered helical hairpin structure with 1.5 turns. The structure of dimer of eicosane molecules has two well ordered helical hairpins that are stacked perpendicular to each other. As a prelude to studying folding in confined spaces we used simulations to understand changes in hydrophobic and ionic interactions in nano droplets. Solvation of hydrophobic and charged species change drastically in nano water droplets. Hydrophobic species are localized at the boundary. The tendency of ions to be at the boundary where water density is low increases as the charge density decreases. Interaction between hydrophobic, polar, and charged residue are also profoundly altered in confined spaces. Using the results of computer simulations and accounting for loss of chain entropy upon confinement we argue and then demonstrate, using simulations in explicit water, that ordered states of generic amphiphilic peptide sequences should be stabilized in cylindrical nanopores

Vacuum solutions of the gravitational field equations in the brane world model

We consider some classes of solutions of the static, spherically symmetric gravitational field equations in the vacuum in the brane world scenario, in which our Universe is a three-brane embedded in a higher dimensional space-time. The vacuum field equations on the brane are reduced to a system of two ordinary differential equations, which describe all the geometric properties of the vacuum as functions of the dark pressure and dark radiation terms (the projections of the Weyl curvature of the bulk, generating non-local brane stresses). Several classes of exact solutions of the vacuum gravitational field equations on the brane are derived. In the particular case of a vanishing dark pressure the integration of the field equations can be reduced to the integration of an Abel type equation. A perturbative procedure, based on the iterative solution of an integral equation, is also developed for this case. Brane vacuums with particular symmetries are investigated by using Lie group techniques. In the case of a static vacuum brane admitting a one-parameter group of conformal motions the exact solution of the field equations can be found, with the functional form of the dark radiation and pressure terms uniquely fixed by the symmetry. The requirement of the invariance of the field equations with respect to the quasi-homologous group of transformations also imposes a unique, linear proportionality relation between the dark energy and dark pressure. A homology theorem for the static, spherically symmetric gravitational field equations in the vacuum on the brane is also proven.Comment: 13 pages, no figures, to appear in PR

Radiative production of invisible charginos in photon photon collision

If in a supersymmetric model, the lightest chargino is nearly degenerate with the lightest neutralino, the former can decay into the latter alongwith a soft pion (or a lepton-neutrino pair). Near degeneracy of the chargino and neutralino masses can cause the other decay products (the pion or the lepton) to be almost invisible. Photon-photon colliders offer a possibility of clean detection of such an event through a hard photon tag.Comment: 12 pages, 5 postscript figure

The Topological Unitarity Identities in Chern-Simons Theories

Starting from the generating functional of the theory of relativistic spinors in 2+1 dimensions interacting through the pure Chern-Simons gauge field, the S-matrix is constructed and seen to be formally the same as that of spinor quantum electrodynamics in 2+1 dimensions with Feynman diagrams having external photon lines excluded, and with the propagator of the topological Chern-Simons photon substituted for the Maxwell photon propagator. It is shown that the absence of real topological photons in the complete set of vector states of the total Hilbert space leads in a given order of perturbation theory to topological unitarity identities that demand the vanishing of the gauge-invariant sum of the imaginary parts of Feynman diagrams with a given number of internal on-shell free topological photon lines. It is also shown, that these identities can be derived outside the framework of perturbation theory. The identities are verified explicitly for the scattering of a fermion-antifermion pair in one-loop order.Comment: 13 pages, LaTex file, one figure (not included