Transient Global Amnesia After Ablation of the Left Lateral Accessory Pathway

Transient global amnesia (TGA) could be encountered in many situations even during invasive procedures. In ablation therapy for arrhythmia, there was only one reported case in the ablation of premature ventricular beats. We report a 31-year-old man having paroxysmal supraventricular tachycardia who underwent TGA at the end of ablation and recovered quickly after 8-9 hours later. Long-term follow-up showed no neurologic deficits for 8 months

How the Design Leadership and Strategic Design Drive New Value in Enterprises and Organizations

Today's design has shifted from the original primary pursuit of appearance and function to processes and systems, creating new meanings for corporate strategies, products and services. Nowadays, enterprises are increasingly paying attention to the power of design, and regard design as the main innovation method and incorporate it into the organizations. Design began to be considered a key role at the top of large organizations. Although people recognize that design can bring good effects to enterprises and organizations, and there is growing interest in cultivating design thinking, what are the leaders who can lead enterprises, organizations and have design thinking? Their characteristics and how to formulate and plan strategic design still not fully elucidated. Therefore, this research uses related theories to understand the way of thinking and characteristics of design leaders, only in this way we formulate good strategic design for enterprises and organizations, and become an indispensable and important help in today rapidly changing world

Regulation of CLC-1 chloride channel biosynthesis by FKBP8 and Hsp90β.

Mutations in human CLC-1 chloride channel are associated with the skeletal muscle disorder myotonia congenita. The disease-causing mutant A531V manifests enhanced proteasomal degradation of CLC-1. We recently found that CLC-1 degradation is mediated by cullin 4 ubiquitin ligase complex. It is currently unclear how quality control and protein degradation systems coordinate with each other to process the biosynthesis of CLC-1. Herein we aim to ascertain the molecular nature of the protein quality control system for CLC-1. We identified three CLC-1-interacting proteins that are well-known heat shock protein 90 (Hsp90)-associated co-chaperones: FK506-binding protein 8 (FKBP8), activator of Hsp90 ATPase homolog 1 (Aha1), and Hsp70/Hsp90 organizing protein (HOP). These co-chaperones promote both the protein level and the functional expression of CLC-1 wild-type and A531V mutant. CLC-1 biosynthesis is also facilitated by the molecular chaperones Hsc70 and Hsp90β. The protein stability of CLC-1 is notably increased by FKBP8 and the Hsp90β inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG) that substantially suppresses cullin 4 expression. We further confirmed that cullin 4 may interact with Hsp90β and FKBP8. Our data are consistent with the idea that FKBP8 and Hsp90β play an essential role in the late phase of CLC-1 quality control by dynamically coordinating protein folding and degradation

Will Your Project Get the Green Light? Predicting the Success of Crowdfunding Campaigns

Capital is always essential for a business project over times. After emerging in 2000, crowdfunding gradually becomes one of the most popular fundraising resources. However, the mechanism of crowdfunding significantly differs from traditional capital-collecting approaches. As long as the amount of pledged money reaches the goal in time, the project succeeds, its initiator receives the funds, the platform gains the revenue, and its backers acquire rewards. Reaching the goal by deadline becomes an important issue. The goal of our study is to develop an effective technique for predicting whether a crowdfunding campaign will succeed or fail. On the basis of a dataset collected from Kickstarter, our empirical evaluation results suggest that our proposed technique significantly outperforms the benchmark method. In addition, with the use of time-dependent factors, the prediction accuracy improves from 72.89% at day 0 to 87.13% at the first day and eventually to 89.62% at day 7

Always Open, Seven-Eleven: Education Targeting Healthier Food Choices in a High Convenience Store Density Area in Taipei

To enhance children's health, the promotion of nutrition literacy in school is vital as it helps prevent the development of health conditions and diseases and maintain healthy lifestyles. Taiwan features the top highest ratio of convenience stores per population density. Convenience stores, an increasingly popular dining place, were linked to the development of eating behavior and body weight issues in children. An eight-week classroom-based nutrition intervention, employing the Traffic Light Diet as a framework, targeting children's perception of and intention to visit the convenience store was implemented. The study conducted a quasi-experimental pretest-posttest research design with a comparison group. A total of 49 students participated in the study, with 25 in the intervention and 24 in the comparison group. Data were collected by utilizing surveys, interviews, and observations. The study's findings demonstrated the positive trajectory of the impact of this intervention on increasing food-and-nutrition-related knowledge and improving healthier diet choices at convenience stores among children. One main theme was identified in coding interviews: parent involvement in meal preparation may reduce convenience store use and increase consumption of vegetables among children. Assessing the influence of parental support for healthy dietary choices, eating nutritious foods at home, and involving the family in meal preparation is an area for future research

Tensor Network Based Finite-Size Scaling for Two-Dimensional Classical Models

We propose a scheme to perform tensor network based finite-size scaling analysis for two-dimensional classical models. In the tensor network representation of the partition function, we use higher-order tensor renormalization group (HOTRG) method to coarse grain the weight tensor. The renormalized tensor is then used to construct the approximated transfer matrix of an infinite strip of finite width. By diagonalizing the transfer matrix we obtain the correlation length, the magnetization, and the energy density which are used in finite-size scaling analysis to determine the critical temperature and the critical exponents. As a benchmark we study the two-dimensional classical Ising model. We show that the critical temperature and the critical exponents can be accurately determined. With HOTRG bond dimension $D=70$, the absolute errors of the critical temperature $T_c$ and the critical exponent $\nu$, $\beta$ are at the order of $10^{-7}, 10^{-5}$, $10^{-4}$ respectively. Furthermore, the results can be systematically improved by increasing the bond dimension of the HOTRG method. Finally, we study the length scale induced by the finite cut-off in bond dimension and elucidate its physical meaning in this context