Scaling Relations for Galaxies Prior to Reionization

The first galaxies in the Universe are the building blocks of all observed galaxies. We present scaling relations for galaxies forming at redshifts $z \ge 15$ when reionization is just beginning. We utilize the ``Rarepeak' cosmological radiation hydrodynamics simulation that captures the complete star formation history in over 3,300 galaxies, starting with massive Population III stars that form in dark matter halos as small as ~$10^6 M_\odot$. We make various correlations between the bulk halo quantities, such as virial, gas, and stellar masses and metallicities and their respective accretion rates, quantifying a variety of properties of the first galaxies up to halo masses of $10^9 M_\odot$. Galaxy formation is not solely relegated to atomic cooling halos with virial temperatures greater than $10^4$ K, where we find a dichotomy in galaxy properties between halos above and below this critical mass scale. Halos below the atomic cooling limit have a stellar mass -- halo mass relationship $\log M_\star \simeq 3.5 + 1.3\log(M_{\rm vir} / 10^7 M_\odot)$. We find a non-monotonic relationship between metallicity and halo mass for the smallest galaxies. Their initial star formation events enrich the interstellar medium and subsequent star formation to a median of $10^{-2} Z_\odot$ and $10^{-1.5} Z_\odot$, respectively, in halos of total mass $10^7 M_\odot$ that is then diluted by metal-poor inflows, well beyond Population III pre-enrichment levels of $10^{-3.5} Z_\odot$. The scaling relations presented here can be employed in models of reionization, galaxy formation and chemical evolution in order to consider these galaxies forming prior to reionization.Comment: 10 pages, 10 figures. Accepted to Ap

Comparative Morphologic Analysis and Geochronology for the Development and Decline of Two Pleistocene Coral Reefs, San Salvador and Great Inagua Islands, Bahamas

Reprinted from: John E. Mylroie (ed.), Proceedings of the 4th Symposium on the Geology of the Bahamas: San Salvador, Bahamian Field Station

Outdoor air pollution and emergency department visits for asthma among children and adults: A case-crossover study in northern Alberta, Canada

<p>Abstract</p> <p>Background</p> <p>Recent studies have observed positive associations between outdoor air pollution and emergency department (ED) visits for asthma. However, few have examined the possible confounding influence of aeroallergens, or reported findings among very young children.</p> <p>Methods</p> <p>A time stratified case-crossover design was used to examine 57,912 ED asthma visits among individuals two years of age and older in the census metropolitan area of Edmonton, Canada between April 1, 1992 and March 31, 2002. Daily air pollution levels for the entire region were estimated from three fixed-site monitoring stations. Similarly, daily levels of aeroallergens were estimated using rotational impaction sampling methods for the period between 1996 and 2002. Odds ratios and their corresponding 95% confidence intervals were estimated using conditional logistic regression with adjustment for temperature, relative humidity and seasonal epidemics of viral related respiratory disease.</p> <p>Results</p> <p>Positive associations for asthma visits with outdoor air pollution levels were observed between April and September, but were absent during the remainder of the year. Effects were strongest among young children. Namely, an increase in the interquartile range of the 5-day average for NO₂and CO levels between April and September was associated with a 50% and 48% increase, respectively, in the number of ED visits among children 2 – 4 years of age (p < 0.05). Strong associations were also observed with these pollutants among those 75 years of age and older. Ozone and particulate matter were also associated with asthma visits. Air pollution risk estimates were largely unchanged after adjustment for aeroallergen levels.</p> <p>Conclusion</p> <p>Our findings, taken together, suggest that exposure to ambient levels of air pollution is an important determinant of ED visits for asthma, particularly among young children and the elderly.</p

Passive Tracking System and Method

System and methods are disclosed for passively determining the location of a moveable transmitter utilizing a pair of phase shifts at a receiver for extracting a direction vector from a receiver to the transmitter. In a preferred embodiment, a phase difference between the transmitter and receiver is extracted utilizing a noncoherent demodulator in the receiver. The receiver includes antenna array with three antenna elements, which preferably are patch antenna elements placed apart by one-half wavelength. Three receiver channels are preferably utilized for simultaneously processing the received signal from each of the three antenna elements. Multipath transmission paths for each of the three receiver channels are indexed so that comparisons of the same multipath component are made for each of the three receiver channels. The phase difference for each received signal is determined by comparing only the magnitudes of received and stored modulation signals to determine a winning modulation symbol

Ozone production efficiencies of acetone and peroxides in the upper troposphere

HOx concentrations in the upper tropical troposphere can be enhanced by the presence of acetone and the convective injection of peroxides. These enhancements in HOx might be expected to increase ozone production by increasing the rate of the HO2+NO reaction. We show however that the convective enhancements of hydrogen peroxide (H2O2) and methyl hydroperoxide (CH3OOH) above steady state during the PEM West B campaign were largely restricted to air parcels of marine boundary layer origin in which the mean NO concentration was 8 pptv. The ozone production efficiencies of the two peroxides at such low NO concentrations are very small. Their impact on the ozone budget of the upper tropical troposphere during PEM West B was therefore probably modest. Unlike the peroxides, acetone in the upper tropical troposphere during PEM West B exhibited a positive correlation with NO. It also has a much larger ozone production efficiency than either H2O2 or CH3OOH. It therefore has a much greater potential for significantly increasing ozone production rates in the upper tropical troposphere

Fourier transform spectroscopy of d-wave quasiparticles in the presence of atomic scale pairing disorder

The local density of states power spectrum of optimally doped Bi$_2$Sr$_2$CaCu$_2$O$_{8+x}$ (BSCCO) has been interpreted in terms of quasiparticle interference peaks corresponding to an "octet'' of scattering wave vectors connecting k-points where the density of states is maximal. Until now, theoretical treatments have not been able to reproduce the experimentally observed weights and widths of these "octet'' peaks; in particular, the predominance of the dispersing "q$_1$'' peak parallel to the Cu-O bond directions has remained a mystery. In addition, such theories predict "background'' features which are not observed experimentally. Here, we show that most of the discrepancies can be resolved when a realistic model for the out-of-plane disorder in BSCCO is used. Weak extended potential scatterers, which are assumed to represent cation disorder, suppress large-momentum features and broaden the low-energy "q$_7$''-peaks, whereas scattering at order parameter variations, possibly caused by a dopant-modulated pair interaction around interstitial oxygens, strongly enhances the dispersing "q$_1$''-peaks.Comment: 7 pages, 3 figure

Chronic viral infection promotes sustained Th1-derived immunoregulatory IL-10 via BLIMP-1

During the course of many chronic viral infections, the antiviral T cell response becomes attenuated through a process that is regulated in part by the host. While elevated expression of the immunosuppressive cytokine IL-10 is involved in the suppression of viral-specific T cell responses, the relevant cellular sources of IL-10, as well as the pathways responsible for IL-10 induction, remain unclear. In this study, we traced IL-10 production over the course of chronic lymphocytic choriomeningitis virus (LCMV) infection in an IL-10 reporter mouse line. Using this model, we demonstrated that virus-specific T cells with reduced inflammatory function, particularly Th1 cells, display elevated and sustained IL-10 expression during chronic LCMV infection. Furthermore, ablation of IL-10 from the T cell compartment partially restored T cell function and reduced viral loads in LCMV-infected animals. We found that viral persistence is needed for sustained IL-10 production by Th1 cells and that the transcription factor BLIMP-1 is required for IL-10 expression by Th1 cells. Restimulation of Th1 cells from LCMV-infected mice promoted BLIMP-1 and subsequent IL-10 expression, suggesting that constant antigen exposure likely induces the BLIMP-1/IL-10 pathway during chronic viral infection. Together, these data indicate that effector T cells self-limit their responsiveness during persistent viral infection via an IL-10-dependent negative feedback loop.This work was supported by an Australian NHMRC Overseas Biomedical Postdoctoral Fellowship (to I.A. Parish); a Yale School of Medicine Brown-Coxe Postdoctoral Fellowship (to I.A. Parish); the Alexander von Humboldt Foundation (SKA2010, to P.A. Lang); a CIHR grant (to P.S. Ohashi); and by the Howard Hughes Medical Institute and NIH grant RO1AI074699 (to S.M. Kaech). P.S. Ohashi holds a Canada Research Chair in Autoimmunity and Tumor immunity

Concise Syntheses of Δ^(12)-Prostaglandin J Natural Products via Stereoretentive Metathesis

Δ^(12)-Prostaglandin J family is recently discovered and has potent anticancer activity. Concise syntheses of four Δ^(12)-prostaglandin J natural products (7–8 steps in the longest linear sequences) are reported, enabled by convergent stereoretentive cross-metathesis. Exceptional control of alkene geometry was achieved through stereoretention