Sensitivity of the mussel Mytilus edulis to substrate‑borne vibration in relation to anthropogenically generated noise

© 2015 Inter-Research. Many anthropogenic activities in the oceans involve direct contact with the seabed (for example pile driving), creating radiating particle motion waves. However, the consequences of these waveforms to marine organisms are largely unknown and there is little information on the ability of invertebrates to detect vibration, or indeed the acoustic component of the signal. We quantified sensitivity of the marine bivalve Mytilus edulis to substrate-borne vibration by exposure to vibration under controlled conditions. Sinusoidal excitation by tonal signals at frequencies within the range 5 to 410 Hz was applied during the tests, using the 'staircase' method of threshold determination. Thresholds were related to mussel size and to seabed vibration data produced by anthropogenic activities. Clear behavioural changes were observed in response to the vibration stimulus. Thresholds ranged from 0.06 to 0.55 m s -2 (acceleration, root mean squared), with valve closure used as the behavioural indicator of reception and response. Thresholds were shown to be within the range of vibrations measured in the vicinity of anthropogenic operations such as pile driving and blasting. The responses show that vibration is likely to impact the overall fitness of both individuals and mussel beds of M. edulis due to disruption of natural valve periodicity, which may have ecosystem and commercial implications. The observed data provide a valuable first step to understanding the impacts of such vibration upon a key coastal and estuarine invertebrate which lives near industrial and construction activity, and illustrate that the role of seabed vibration should not be underestimated when assessing the impacts of noise pollution

The Effects of Kinesio Tape on Postural Control in Female Athletes With Chronic Ankle Instability

Please refer to the pdf version of the abstract located adjacent to the title

Multi-Retranslation Corpora: Visibility, Variation, Value, and Virtue

Variation among human translations is usually invisible, little understood, and under-valued. Previous statistical research finds that translations vary most where the source items are most semantically significant or express most ‘attitude’ (affect, evaluation, ideology). Understanding how and why translations vary is important for translator training and translation quality assessment, for cultural research, and for machine translation development. Our experimental project began with the intuition that quantitative variation in a corpus of historical retranslations might be used to project quasi-qualitative annotations onto the translated text. We present a web-based system which enables users to create parallel, segment-aligned multi-version corpora, and provides visual interfaces for exploring multiple translations, with their variation projected onto a base text. The system can support any corpus of variant versions. We report experiments using our tools (and stylometric analysis) to investigate a corpus of 40 German versions of a work by Shakespeare. Initial findings lead to more questions than answers

The p factor: genetic analyses support a general dimension of psychopathology in childhood and adolescence

Background: Diverse behaviour problems in childhood correlate phenotypically, suggesting a general dimension of psychopathology that has been called the p factor. The shared genetic architecture between childhood psychopathology traits also supports a genetic p. This study systematically investigates the manifestation of this common dimension across self‐, parent‐ and teacher‐rated measures in childhood and adolescence. / Methods: The sample included 7,026 twin pairs from the Twins Early Development Study (TEDS). First, we employed multivariate twin models to estimate common genetic and environmental influences on p based on diverse measures of behaviour problems rated by children, parents and teachers at ages 7, 9, 12 and 16 (depressive traits, emotional problems, peer problems, autism traits, hyperactivity, antisocial behaviour, conduct problems and psychopathic tendencies). Second, to assess the stability of genetic and environmental influences on p across time, we conducted longitudinal twin modelling of the first phenotypic principal components of childhood psychopathological measures across each of the four ages. Third, we created a genetic p factor in 7,026 unrelated genotyped individuals based on eight polygenic scores for psychiatric disorders to estimate how a general polygenic predisposition to mostly adult psychiatric disorders relates to childhood p. / Results: Behaviour problems were consistently correlated phenotypically and genetically across ages and raters. The p factor is substantially heritable (50%–60%) and manifests consistently across diverse ages and raters. However, residual variation in the common factor models indicates unique contributions as well. Genetic correlations of p components across childhood and adolescence suggest stability over time (49%–78%). A polygenic general psychopathology factor derived from studies of psychiatric disorders consistently predicted a general phenotypic p factor across development (0.3%–0.9%). / Conclusions: Diverse forms of psychopathology generally load on a common p factor, which is highly heritable. There are substantial genetic influences on the stability of p across childhood. Our analyses indicate genetic overlap between general risk for psychiatric disorders in adulthood and p in childhood, even as young as age 7. The p factor has far‐reaching implications for genomic research and, eventually, for diagnosis and treatment of behaviour problems.

Probing a Complex of Cytochromecand Cardiolipin by Magnetic Circular Dichroism Spectroscopy: Implications for the Initial Events in Apoptosis

Oxidation of cardiolipin (CL) by its complex with cytochrome c (cyt c) plays a crucial role in triggering apoptosis. Through a combination of magnetic circular dichroism spectroscopy and potentiometric titrations, we show that both the ferric and ferrous forms of the heme group of a CL:cyt c complex exist as multiple conformers at a physiologically relevant pH of 7.4. For the ferric state, these conformers are His/Lys- and His/OH–-ligated. The ferrous state is predominantly high-spin and, most likely, His/–. Interconversion of the ferric and ferrous conformers is described by a single midpoint potential of -80 ± 9 mV vs SHE. These results suggest that CL oxidation in mitochondria could occur by the reaction of molecular oxygen with the ferrous CL:cyt c complex in addition to the well-described reaction of peroxides with the ferric form

Alternatives to mental health admissions for children and adolescents experiencing mental health crises: A systematic review of the literature

Background: Many children and young people (CYP) presenting with mental health crises are admitted to hospital due to concerns around illness severity and risk. Whilst inpatient admissions have an important role for such children, there are a number of burdens associated with them, and safe avoidance of admissions is favourable. We systematically reviewed the literature for studies of interventions reported as alternatives to a hospital admission in CYP presenting with mental health crises, in any inpatient setting. Methods: Three databases (PsychInfo, PubMed and Web of Science) were searched for peer-reviewed papers in October 2020, with an updated search in May 2021. Results: We identified 19 papers of interventions delivered in the emergency department, the home, outside of home but outside of clinics and in hospital clinics. The quality of most included studies was low, with less than half being randomised controlled trials and only half of these at low risk of bias. The best quality studies and greatest evidence for efficacy came from in-home interventions, in particular multisystemic therapy, which improved psychological outcomes, and though a large number of CYP still ended up being admitted, there appeared to be decreased length of stay. Conclusions: Overall, we could not recommend a particular intervention as an alternative to inpatient admission; however, our review describes benefits across a range of types of interventions that might be considered in multi-modal treatments. We also provide recommendations for future research, in particular the evaluation of new interventions as they emerge

Characterization of the S = 9 excited state in Fe8Br8 by Electron Paramagnetic Resonance

High Frequency electron paramagnetic resonance has been used to observe the magnetic dipole, $\Delta$ M$_s$ = $\pm$ 1, transitions in the $S = 9$ excited state of the single molecule magnet Fe$_8$Br$_8$. A Boltzmann analysis of the measured intensities locates it at 24 $\pm$ 2 K above the $S = 10$ ground state, while the line positions yield its magnetic parameters D = -0.27 K, E = $\pm$0.05 K, and B$_4^0$ = -1.3$\times$ 10$^{-6}$ K. D is thus smaller by 8% and E larger by 7% than for $S = 10$. The anisotropy barrier for $S = 9$ is estimated as 22 K,which is 25% smaller than that for $S = 10$ (29 K). These data also help assign the spin exchange constants(J's) and thus provide a basis for improved electronic structure calculations of Fe$_8$Br$_8$.Comment: 7 pages, Figs included in text, submitted to PR