Photobiomodulation reduces inflammation but does not influence the hypoxia-inducible factor-1α in pulp tissue of rats after bleaching

Objectives: To evaluate the influence of photobiomodulation with infrared laser (IRL) in the rat pulp tissue after bleaching, considering the immunolabeling of interleukin (IL)-23 and hypoxia-inducible factor (HIF)-1α. Methodology: The right and left molars of forty rats were divided into groups: Control – with placebo gel and Bleached – with 35% hydrogen peroxide (H2O2). Half of the rats received one IRL application on both sides, establishing a split-mouth design, which resulted in 4 groups with 20 hemi-maxillae each: Control, Bleach, IRL, and Bleached-IRL. Rats (n=10) from each group were euthanized, at 2- and 30-days mark, and the pulp tissue was evaluated using inflammation and immunolabeling scores. Wilcoxon and Mann-Whitney statistical tests were performed (p<0.05). Results: At the 2-days mark, the Bleached group had severe inflammation and necrosis in the occlusal thirds of the pulp, and moderate to severe inflammation in cervical third, whereas the Bleached-IRL had mild to moderate inflammation (p<0.05). At the 30-days mark, there was no inflammation, but tertiary dentine formation in the bleached groups. Regarding IL-23, severe immunolabeling was observed in the Bleached group (p<0.05) at the 2-days mark; at the 30-days mark, there was a reduction in immunolabeling, in which the Bleached group had moderate and the Bleached-IRL group had mild immunolabeling (p>0.05). HIF-1α was more evident at the 2-days mark in the Bleached group, without significant difference with the Bleached-IRL (p>0.05). The difference was observed between the bleached and control groups, without immunolabeling (p<0.05); at the 30-days mark, the Bleached group had reduction in HIF-1α immunolabeling, while the Bleached-IRL had an increase; the difference remained between the bleached and the controls groups (p<0.05). Conclusion: Photobiomodulation using IRL minimized the inflammation and IL-23 immunolabeling in the pulp tissue of rats after dental bleaching, but did not influence significantly the HIF-1α immunolabeling

Agregado trióxido mineral (mta) como material obturador associado à reabsorção interna radicular: relato de caso

Objetivo: relatar um caso clínico acompanhado desde o ano de 2013. Paciente do gênero feminino, 28 anos, compareceu a Clínica Odontológica, queixando-se de dor no elemento 11. Relato de Caso: na primeira consulta foi observada a presença de uma fístula e grande aumento de volume na região de palato. Devido às características clínicas observadas, foi solicitada uma radiografia periapical e após observar uma região radiolúcida ocorreu o questionamento se seria uma reabsorção radicular interna. A realização de preparo químico-mecânico e aplicação da pasta de Hidróxido de Cálcio fizeram com que a fístula e o edema sumissem. Na consulta final, a pasta foi removida e foi realizada a obturação com MTA. Conclusão: baseado no exposto, conclui-se que a remodelação óssea implica na reabsorção constante das estruturas mineralizadas, mas também ocorre formação contínua de osso, inclusive na superfície periodontal do alvéolo dentári

Comparison of niobium to other radiopacifying agents in endodontic cements: A Systematic Review of in vitro and in vivo studies

As of the current moment, no systematic comparative review has been identified between the chemical element niobium and other radiopaque substances when incorporated into formulations of endodontic cements and reparative cements. Additionally, no prior records of protocols related to this topic have been found in the scientific literature. Consequently, this study holds the potential to serve as a valuable guide for future clinical guidelines related to the use of niobium as a radiopaque agent in endodontic cements. It's worth noting that the current registration has been submitted and recorded on the Open Science Framework (OSF) due to its scope encompassing a systematic review of in vivo studies investigating niobium and other radiopaque substances in formulations of endodontic cements and/or reparative cements. The protocol for this systematic review adheres to the guidelines outlined by PRISMA-P for systematic review protocols. For a comprehensive description of all the steps to be undertaken within the scope of this systematic review, we refer the reader to the supplementary material, which provides a more detailed exposition