Antifungal, antioxidant and larvicidal activities of compounds isolated from the heartwood of Mansonia gagei

Eleven compounds isolated from the heartwood of Mansonia gagei were tested for their antifungal activities against Cladosporium cucumerinum and Candida albicans, as well as for their larvicidal activities against Aedes aegypti and radical scavenging properties in a DPPH assay. Mansonone C (4) was found to be the most interesting compound with antifungal activities against Cladosporium cucumerinum and Candida albicans as well as for its larvicidal properties against Aedes aegypti. Mansonone E (5) was active against Cladosporium cucumerinum and Candida albicans. Two coumarin derivatives, mansorin A (1) and mansorin B (2) were also found to be active against Cladosporium cucumerinum, while mansonone N (9) was the only isolated product to show radical scavenging properties. Copyright (C) 2003 John Wiley Sons, Ltd

Four new sesquiterpenoid derivatives from the heartwood of Mansonia gage.

Four new sesquiterpenoid derivatives named mansonones N (1), O (2), P (3), and Q (4) were isolated from a dichloromethane extract of the heartwood of Mansonia gagei, a plant used in folk medicine in Thailand. Their structures were resolved on the basis of spectrometric data interpretation and the single-crystal X-ray analysis of 1 and 2

Dibromopinocembrin and Dibromopinostrobin Are Potential Anti-Dengue Leads with Mild Animal Toxicity

10.3390/molecules25184154Molecules2518415

Two novel diterpenes from the roots of Phyllanthus acidus (L.) Skeel

International audienceTwo novel diterpenes, phyllanes A and B, were isolated from the roots of Phyllanthus acidus, along with the cleistanthane diterpene, spruceanol. Their chemical structures were unambiguously elucidated by extensive 1D and 2D NMR analyses and high resolution mass spectroscopic data, as well as by comparison with literature data. While phyllanes A and B are respectively reminiscent of amphilectane and serrulatane diterpenoids, their highly unusual substitution patterns and their co-occurrence with spruceanol led us to assume that they might correspond to an unprecedented type of re-arranged cleistanthane-diterpenoid precursors, resulting in final products that display a unique scaffold among terrestrial diterpenoids. Accordingly, a possible biosynthetic route to the two new compounds from the readily accessible spruceanol is proposed herein. These two compounds were evaluated for their cytotoxic activities against two cancer cell lines. Only phyllane B exerted a moderate activity against K562 and HepG2 cell line with IC50 values of 28.90 and 45.23 μg/mL, respectively. © 201

Author Correction: The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase (Scientific Reports, (2023), 13, 1, (4891), 10.1038/s41598-023-32049-x)

10.1038/s41598-023-34883-5Scientific Reports1317651

Tsavoenones A-C Unprecedented polyketides with a 1,7-dioxadispiro[4.0.4.4]tetradecane core from the lichen Parmotrema tsavoense

International audienceNew racemic dispiranic polyketides, tsavoenones A (1), B (2) and C (3), having a novel 1,7-dioxadispiro[4.0.4.4]tetradecane scaffold were isolated from the foliose lichen Parmotrema tsavoense. These compounds were structurally elucidated by extensive NMR analyses, comparison between experimental and theoretical 13C NMR data and X-ray crystallography. A putative biosynthetic scenario for the formation of 1-3 from parmosidone D, a meta-depsidone previously isolated from the same lichen material, was proposed. Tested for its cytotoxicity, 1 displayed a moderate activity against human myelogenous leukemia K562 cell line with an IC50 value of 66 μg mL-1. © 2018 The Royal Society of Chemistry

Sanctis A–C Three Racemic Procyanidin Analogues from The Lichen Parmotrema sancti-angelii

International audienceThe phytochemical investigation of the lichen Parmotrema sancti-angelii afforded three racemic compounds, sanctis A–C, which feature an original dibenzo-2,8-dioxabicyclo[3.3.1]nonane scaffold. These compounds were structurally characterized by extensive NMR spectroscopy analyses, comparison between experimental and theoretical NMR spectroscopic data, and X-ray crystallography. These metabolites are similar to procyanidin A and display a methyl group instead of a pendant aromatic ring at C-9, a so far unprecedented structural feature. A biosynthetic route to sanctis A–C is proposed