Giant lipoleiomyoma-an intimidating entity: case report and literature review

Lipomatous uterine neoplasms are extremely uncommon lesions with a reported incidence of 0.01% to 0.2%. These lesions frequently pose a diagnostic challenge not only for the clinician but also for radiologists and pathologists alike. Diagnosis requires a multidisciplinary as well as multimodality approach. A 42-year-old peri-menopausal lady presented with abdominal distension, pain and irregular menstrual bleeding. On radiology, an intra-abdodominal hetergenous mass was seen suggestive of neoplastic etiology, possibly intraperitoneal liposarcoma. Microscopy revealed numerous adipocyte clusters intersecting the smooth muscle bundles, diagnostic of lipoleiomyoma. The present case is unusual as the patient had both intramural and broad ligament lipoleiomyoma. Through the present case we revisit clinical and morphological findings of lipoleiomyomas along with review of cases published in literature till date

Unusual presentation of renal cell carcinoma: A rare case report

Cutaneous and intraoral metastasis from any malignancy is not common. Cutaneous spread is usually noted in 5%–10% of high-grade malignancies, as in carcinoma breast, lung, colon, ovary, and malignant melanoma. Only 4.6% cases of cutaneous spread are from renal cell carcinoma (RCC). Intraoral spread from RCC is much rarer with an incidence of approximately 1% of all malignant oral tumors, noted sometimes in tongue, palate, buccal mucosa, gingiva, and lips. RCC is a highly aggressive tumor which requires early diagnosis for increasing the chance of cure. In our case, a 54-year-old male presented with swelling over upper lip, scalp, and retromolar area, which on histopathology and immunohistochemistry revealed clear cell carcinoma compatible with metastatic RCC

Coronary arteritis as a cause of sudden cardiac death in a young girl

A case of probable coronary arteritis in a young girl who died suddenly and unexpectedly is presented. The histologic presentation of the disorder is discussed, especially the differential diagnosis of arteritis of the coronary arteries with an emphasis on tuberculosis (TB). TB myocarditis with or without concomitant lung involvement is rare, and tubercular coronary arteritis without underlying pulmonary Koch’s disease is all the rarer. We herein describe a case where the cause of death was ascertained on post-mortem examination

Electroluminescent characteristics of bis(5-chloro-8-hydroxyquinolinato)- zinc(II) complex

A zinc(II) complex with 5-chloro-8-hydroxyquinoline has been used as emitting material to produce yellow light. On excitation by UV light at 385 nm, thin film of the complex fluoresced at 550 nm. Multilayer organic electroluminescence devices fabricated using this fluorescent material produce emission with good chromaticity (CIE coordinates x = 0.313 and y = 0.576). Maximum luminance of 466 cd/m2 is achieved when 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane is used as dopant in 4,4-bis[N-(1-naphthyl)-N-phenyl-amino]biphenyl at 12 V. The devices show typical non-linear diode current-voltage characteristics under forward bias with the threshold voltage of 6V. The CIE coordinates are found to be independent of the operating voltage

Epithelioid inflammatory myofibroblastic sarcoma: the youngest case reported

Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare variant of the inflammatory myofibroblastic tumor. It has an aggressive clinical course and a high rate of recurrence. EIMS primarily affects children and young adults. Hereby, we report this entity in a 4-month-old infant who presented with an abdominal mass. Imaging studies revealed a large hypodense mesentery-based lesion involving the right half and mid-region of the abdomen. The mass with an attached segment of the small bowel was excised in toto. Grossly, a large encapsulated tumor was identified arising from the mesentery of the small bowel. The histological examination showed a tumor consisting of epithelioid to spindle cells loosely arranged in a myxoid background with numerous blood vessels and lymphoplasmacytic inflammatory infiltrate. On immunohistochemistry, the tumor cells showed positivity for ALK1 (nuclear), desmin, SMA, CD68, and focal positivity for CD30. A final diagnosis of EIMS of the small intestine was rendered. To the best of our knowledge, this case is the youngest reported case in literature

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Not AvailableBreeding of heat-tolerant cultivars requires knowledge of the genetic behavior of morpho-physiological traits. Gene action was investigated using wide phenotypic segregation ranging across six generations (P1, P2, F1, BC1, BC2 and F2) of four different tolerant×sensitive crosses for grain flling duration, GFD (40.14–46.20); canopy temperature depression, CTD (2.42– 5.97); normalized diference vegetation index, NDVI (0.35–0.61); membrane thermostability index, MSI (31.40–40.93); no. of grains/spike, GN/SP (26.29–54.80); thousand-grain weight, TGW (31.70–44.45); and grain yield/plant, GY (15.37–24.89) under terminal heat stress. Scaling results indicated an absence of epistasis for MSI and TGW in cross PBN51×HUW510. The prominence of Dominance×dominance interaction over additive×additive and additive×dominance interactions along with signifcant dominant gene efect [h] for all traits except MSI was observed. For MSI, similar signs of [d] and [i] along with signifcant [j] showed the possibility of exploitation of additive gene efect. CTD, NDVI and GN/SP were controlled by duplicated epistasis, whereas both complementary and duplicate epistasis was found for GFD. Digenic interactions with prominent duplicate epistasis indicate that biparental mating or diallel selective mating might be efciently utilized for their improvement. The present investigation indicated a preponderance of non-additive gene action for studied traits, thus, implying toward delaying of selection to the later generations to exploit transgressive segregants. Any conventional breeding strategy would be followed for generating the cultivars with low CTD, reduced cell membrane injury, with higher NDVI, TGW, GFD, no. of grains/spike and grain yield/plant.Not Availabl

White organic light emitting diodes based on DCM dye sandwiched in 2-methyl-8-hydroxyquinolinolatolithium

Stable white electroluminescence (EL) has been achieved from organic LED, in which an ultrathin 4-(dicyanomethylene)-2-methyl-6-(p-dimethyl-aminostyryl)-4H-pyran (DCM) dye layer has been inserted in between two 2-methyl-8-hydroxyquinolinolatolithium [LiMeq] emitter layer and by optimizing the position of the DCM dye layer from the α-NPD/LiMeq interface. Electroluminescence spectra, current–voltage–luminescence (I–V–L) characteristics of the devices have been studied by changing the position of the dye layer. As the distance of DCM layer from α-NPD/LiMeq interface is increased, the intensity of host emission enhances rapidly. Introduction of thin layer of DCM in emissive layer increases the turn on voltage. The best Commission International de L’ Eclairage (CIE) coordinates i.e. (0.32, 0.33) were obtained with device structure ITO/α-NPD(30 nm) /LiMeq(10 nm)/DCM(1 nm)/LiMeq(25 nm)/BCP(6 nm)/Alq3(28 nm)/LiF(1 nm)/Al(100 nm). The EL spectrum covers the whole visible spectra range 400–700 nm. The color rendering index (CRI) for our best white light (Device 4) is 47.4. The device shows very good color stability in terms of CIE coordinates with voltages. The maximum luminescence 1240 cd/m−2 has been achieved at 19 V

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Not AvailableGenetic improvement along with widened crop base necessitates for the detailed understanding of the genetic diversity and population structure in wheat. The present investigation reports the discovery of a total of 182 alleles by assaying 52 simple sequence repeats (SSRs) on 40 genotypes of bread wheat. Unweighted neighbour-joining method grouped these genotypes into two main clusters. Highly heat tolerant and intermediate tolerant cultivars were grouped in the same cluster, whereas remaining genotypes, particularly sensitive ones, were assigned different cluster. Similarly, the entire population was structured into two sub-populations (K = 2), closely corresponding with the other distance-based clustering patterns. The marker-trait association was discovered for four important physiological parameters, viz. canopy temperature depression, membrane thermostability index (MSI), normalized difference vegetation index and heat susceptibility index, indicating for heat stress (HS) tolerance in wheat. Both general and mixed linear models of association studies during 2017 and 2018, revealed the association of SSR markers, wmc222 (17.60%, PV) and gwm34 (20.70%, PV) with the mean phenotypic value of MSI. Likewise, SSR markers barc183, gwm75, gwm11 and cfd7 revealed a unique relationship with four selected physiological traits. Candidate genes discovered using in silico tools had nine SSR markers within the genic regions reported to play a role in heat and drought stress responses in plants. The information generated about these genic regions may be explored further in expression studies in-vivo to impart HS tolerance in bread wheat.Not Availabl

Role of Human Epididymis Protein 4 in Tumour Angiogenesis

HE4 is a secretory protein. It is expressed in reproductive tract and respiratory epithelium in normal individuals. Serum level of HE4 is raised in various solid cancers that give us an advantage to use it as a diagnostic and prognostic biomarker. It is an established biomarker of epithelial ovarian cancer [EOC]. It has also shown the significance in various other malignancies like cancer of endometrium, cervix, lung and breast. Studies show HE4 as an independent prognostic biomarker in non-small cell lung carcinoma. Its raised values in cancer signify its role in oncogenesis. HE4 promotes angiogenesis via STAT3 signalling pathway. In this paper we have tried to illustrate about human epididymis protein 4 and its role in tumour angiogenesis