Vanishing corrections on the intermediate scale and implications for unification of forces

In two-step breaking of a class of grand unified theories including SO(10),we prove a theorem showing that the scale $M_I$ where the Pati-Salam gauge symmetry with parity breaks down to the standard gauge group,has vanishing corrections due to all sources emerging from higher scales $\mu >M_I$ such as the one-loop and all higher loop effects,the GUT-threshold,gravitational smearing,and string threshold effects. Implications of such a scale for the unification of gauge couplings with small Majorana neutrino masses are discussed.In string inspired SO(10) we show that $M_I \simeq 5\times 10^{12}$,needed for neutrino masses,with the GUT scale $M_U \simeq M_{str}$ can be realized provided certain particle states in the predicted spectum are light.Comment: 21 pages, Late

Application of phasor measurement units for monitoring power system dynamic performance

This Working Group is a sequel to a previous working group on Wide Area Monitoring and Control for Transmission Capability Enhancement, which published the Technical Brochure 330 in 2007. Since then the synchrophasor technology has advanced rapidly and many utilities around the world have installed hundreds of PMUs in their networks. In this Technical Brochure, we look at the current state of the technology and the extent to which it has been used in the industry. As the technology has matured, it is also important to understand the communication protocols used in synchrophasor networks and their relevant cyber-security issues. These concerns are briefly discussed in the brochure. The applications of Phasor Measurement Units (PMU) measurements reported here are divided into three categories: (a) applications already installed in utility networks, (b) applications that are well-tested, but not yet installed, and (c) applications that are beneficial to the industry, but not fully developed yet. The most common and mature applications are wide area monitoring, state estimation, and model validation. Out of these three applications, wide area monitoring is well established in the industry. The protection and control applications are emerging as evident from the reported examples. The experience of using remote synchrophasor measurements as feedback control signals is not widely reported by the industry. In parallel to this Working Group, Study Committee B5 had a Working Group on “Wide area protection and control technologies.” The Technical Brochure 664 published by this Working Group in September 2016 reviews synchrophasor technology and discusses the industry experience with wide area protection and control. The North American synchrophasor Initiative (NASPI) is another technical group that has gathered and reported a wide range of PMU experiences of industry and researchers. In summary, the field-tested applications presented in this Technical Brochure are a testimony to the confidence of utilities in the synchrophasor technology. The progress in state estimation techniques indicates that synchrophasor measurements will become a standard part of energy management and security assessment systems in the near future

Seropositivity to Herpes Simplex Virus Antibodies and Risk of Alzheimer's Disease: A Population-Based Cohort Study

International audienceBACKGROUND: Herpes Simplex Virus (HSV) infection has been proposed as a possible risk factor of Alzheimer's Disease (AD) notably because it is neurotropic, ubiquitous in the general population and able to establish lifelong latency in the host. The fact that HSV was present in elderly subjects with AD suggests that the virus could be a co-factor of the disease. We investigated the risk of developing AD in anti-HSV immunoglobulin G (IgG) positive subjects (indicator of a lifelong infection to HSV) and IgM-positive subjects (indicator of primary infection or reactivation of the virus) in a longitudinal population-based cohort of elderly subjects living in the community. METHODS: Cox proportional hazard models were used to study the risk of developing AD according to the presence or not of anti-HSV IgG and IgM antibodies, assessed in the sera of 512 elderly initially free of dementia followed for 14 years. RESULTS: During the follow-up, 77 incident AD cases were diagnosed. Controlled for age, gender, educational level and Apolipoprotein E4 (APOE4) status, IgM-positive subjects showed a significant higher risk of developing AD (HR = 2.55; 95% CI [1.38-4.72]), although no significant increased risk was observed in IgG-positive subjects (HR = 1.67; 95%CI [0.75-3.73]). No modification effect with APOE4 status was found. CONCLUSION: Reactivation of HSV seropositivity is highly correlated with incident AD. HSV chronic infection may therefore be contributive to the progressive brain damage characteristic of AD

Theatre and time ecology: deceleration in Stifters Dinge

This article explores the production of ‘time ecology’ in two works of postdramatic theatre: Heiner Goebbels’ Stifters Dinge (2007) and Philippe Quesne’s L’Effet de Serge (2007). By focusing on the practice of deceleration, it argues that theatre’s ecological potential resides not so much in its ability to represent the world, but rather in its capacity for producing new types of temporal experience that purposefully seek to break with modernity’s regime of historicity and the accelerated rhythms that it has given rise to. Importantly, my concern with deceleration is not an argument for slowness per se; on the contrary, I am interested in highlighting the presence of multiple and interpenetrating timescales and rhythms. As well as exposing the full extent of theatre’s temporal potential, such a concern with postdramatic ‘chronographies’ offers an implicit critique of dramatic theatre’s extant practices of eco-dramaturgy that, all too often, attempt to construct a linear narrative which is invested in conventional sequential models of temporality (beginning, middle, end)

Adding a performance-oriented perspective to data warehouse design

Abstract. Data warehouse design is clearly dominated by the business perspective. Quite often, data warehouse administrators are lead to data models with little room for performance improvement. However, the increasing demands for interactive response time from the users make query performance one of the central problems of data warehousing today. In this paper we defend that data warehouse design must take into account both the business and the performance perspective from the beginning, and we propose the extension to typical design methodologies to include performance concerns in the early design steps. Specific analysis to predicted data warehouse usage profile and meta-data analysis are proposed as new inputs for improving the transition from logical to physical schema. The proposed approach is illustrated and discussed using the TPC-H performance benchmark and it is shown that significant performance improvement can be achieved without jeopardizing the business view required for data warehouse models.

Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma.

BACKGROUND: Death from pancreatic ductal adenocarcinoma (PDAC) is rising across the world and PDAC is predicted to be the second most common cause of cancer death in the USA by 2030. Development of effective biotherapies for PDAC are hampered by late presentation, a low number of differentially expressed molecular targets and a tumor-promoting microenvironment that forms both a physical, collagen-rich barrier and is also immunosuppressive. In 2017 Pancreatic Cancer UK awarded its first Grand Challenge Programme award to tackle this problem. The team plan to combine the use of novel CAR T cells with strategies to overcome the barriers presented by the tumor microenvironment. In advance of publication of those data this review seeks to highlight the key problems in effective CAR T cell therapy of PDAC and to describe pre-clinical and clinical progress in CAR T bio-therapeutics