6,932 research outputs found
Fluctuations at a constrained liquid-solid interface
Open Access. This material is posted here with the permission of the publisher.We study the interface between a solid trapped within a bath of liquid by a suitably shaped nonuniform external potential. Such a potential may be constructed using lasers, external electric or magnetic fields, or a surface template. We study a two-dimensional case where a thin strip of solid, created in this way, is surrounded on either side by a bath of liquid with which it can easily exchange particles. Since height fluctuations of the interface cost energy, this interface is constrained to remain flat at all length scales. However, when such a solid is stressed by altering the depth of the potential beyond a certain limit, it responds by relieving stress by novel interfacial fluctuations, which involve addition or deletion of entire lattice layers of the crystal. This “layering” transition is a generic feature of the system regardless of the details of the interaction potential. We show how such interfacial fluctuations influence mass, momentum, and energy transport across the interface. Tiny momentum impulses produce weak shock waves, which travel through the interface and cause the spallation of crystal layers into the liquid. Kinetic and energetic constraints prevent spallation of partial layers from the crystal, a fact which may be of some practical use. We also study heat transport through the liquid-solid interface and obtain the resistances in liquid, solid, and interfacial regions (Kapitza resistance) as the solid undergoes such layering transitions. Heat conduction, which shows strong signatures of the structural transformations, can be understood using a free volume calculation
Heat conduction through a trapped solid: the effect of structural changes on thermal conductance
Deconfinement and the Hagedorn Transition in String Theory
Superseded and extended in hep-th/0105110 and hep-th/0208112.Comment: Superseded and extended in hep-th/0105110 and hep-th/020811
Inositol phosphatase SHIP1 is a primary target of miR-155
MicroRNA-155 (miR-155) has emerged as a critical regulator of immune cell development, function, and disease. However, the mechanistic basis for its impact on the hematopoietic system remains largely unresolved. Because miRNAs function by repressing specific mRNAs through direct 3′UTR interactions, we have searched for targets of miR-155 implicated in the regulation of hematopoiesis. In the present study, we identify Src homology-2 domain-containing inositol 5-phosphatase 1 (SHIP1) as a direct target of miR-155, and, using gain and loss of function approaches, show that miR-155 represses SHIP1 through direct 3′UTR interactions that have been highly conserved throughout evolution. Repression of endogenous SHIP1 by miR-155 occurred following sustained over-expression of miR-155 in hematopoietic cells both in vitro and in vivo, and resulted in increased activation of the kinase Akt during the cellular response to LPS. Furthermore, SHIP1 was also repressed by physiologically regulated miR-155, which was observed in LPS-treated WT versus miR-155−/− primary macrophages. In mice, specific knockdown of SHIP1 in the hematopoietic system following retroviral delivery of a miR-155-formatted siRNA against SHIP1 resulted in a myeloproliferative disorder, with striking similarities to that observed in miR-155-expressing mice. Our study unveils a molecular link between miR-155 and SHIP1 and provides evidence that repression of SHIP1 is an important component of miR-155 biology
High-resolution 3D weld toe stress analysis and ACPD method for weld toe fatigue crack initiation
Weld toe fatigue crack initiation is highly dependent on the local weld toe stress-concentrating geometry including any inherent flaws. These flaws are responsible for premature fatigue crack initiation (FCI) and must be minimised to maximise the fatigue life of a welded joint. In this work, a data-rich methodology has been developed to capture the true weld toe geometry and resulting local weld toe stress-field and relate this to the FCI life of a steel arc-welded joint. To obtain FCI lives, interrupted fatigue test was performed on the welded joint monitored by a novel multi-probe array of alternating current potential drop (ACPD) probes across the weld toe. This setup enabled the FCI sites to be located and the FCI life to be determined and gave an indication of early fatigue crack propagation rates. To understand fully the local weld toe stress-field, high-resolution (5 mu m) 3D linear-elastic finite element (FE) models were generated from X-ray micro-computed tomography (mu-CT) of each weld toe after fatigue testing. From these models, approximately 202 stress concentration factors (SCFs) were computed for every 1 mm of weld toe. These two novel methodologies successfully link to provide an assessment of the weld quality and this is correlated with the fatigue performance
M-Theory on (K3 X S^1)/Z_2
We analyze -theory compactified on where the
changes the sign of the three form gauge field, acts on as a parity
transformation and on K3 as an involution with eight fixed points preserving
SU(2) holonomy. At a generic point in the moduli space the resulting theory has
as its low energy limit N=1 supergravity theory in six dimensions with eight
vector, nine tensor and twenty hypermultiplets. The gauge symmetry can be
enhanced (e.g. to ) at special points in the moduli space. At other
special points in the moduli space tensionless strings appear in the theory.Comment: LaTeX file, 11 page
Differentially Private Model Selection with Penalized and Constrained Likelihood
In statistical disclosure control, the goal of data analysis is twofold: The
released information must provide accurate and useful statistics about the
underlying population of interest, while minimizing the potential for an
individual record to be identified. In recent years, the notion of differential
privacy has received much attention in theoretical computer science, machine
learning, and statistics. It provides a rigorous and strong notion of
protection for individuals' sensitive information. A fundamental question is
how to incorporate differential privacy into traditional statistical inference
procedures. In this paper we study model selection in multivariate linear
regression under the constraint of differential privacy. We show that model
selection procedures based on penalized least squares or likelihood can be made
differentially private by a combination of regularization and randomization,
and propose two algorithms to do so. We show that our private procedures are
consistent under essentially the same conditions as the corresponding
non-private procedures. We also find that under differential privacy, the
procedure becomes more sensitive to the tuning parameters. We illustrate and
evaluate our method using simulation studies and two real data examples
Learning Arbitrary Statistical Mixtures of Discrete Distributions
We study the problem of learning from unlabeled samples very general
statistical mixture models on large finite sets. Specifically, the model to be
learned, , is a probability distribution over probability
distributions , where each such is a probability distribution over . When we sample from , we do not observe
directly, but only indirectly and in very noisy fashion, by sampling from
repeatedly, independently times from the distribution . The problem is
to infer to high accuracy in transportation (earthmover) distance.
We give the first efficient algorithms for learning this mixture model
without making any restricting assumptions on the structure of the distribution
. We bound the quality of the solution as a function of the size of
the samples and the number of samples used. Our model and results have
applications to a variety of unsupervised learning scenarios, including
learning topic models and collaborative filtering.Comment: 23 pages. Preliminary version in the Proceeding of the 47th ACM
Symposium on the Theory of Computing (STOC15
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