Placental cord drainage during third stage of labour: a randomized control trial at a tertiary care centre

Background: Labour is a physiological process, but it is often associated with morbidity and mortality, with the most common cause being blood loss. Primary postpartum hemorrhage is commonly defined as a blood loss of 500 ml or more within 24 hours after normal vaginal birth. A prolonged third stage of labour (more than 20 min) is associated with postpartum hemorrhage. The present study was undertaken with the objective of assessing efficacy of placental cord drainage (PCD) during active management of third stage of labour.Methods: This is a randomized control trial in which full term primi gravida who were expected to have normal vaginal delivery, admitted in labour room of a tertiary care centre were evaluated for inclusion in the study. Total 126 participants were enrolled after having normal vaginal delivery. In study group (n = 63), placental cord drainage was used for management of third stage of labour while in control group (n = 63), third stage was managed without PCD.Results: The mean difference in duration of third stage of labour in study and control group was 1.79 minute and the mean difference in blood loss during third stage of labour in both groups was 57.86 ml which was statistically significant.Conclusions: The results of this study show small positive effects from cord drainage in reducing the length of the third stage of labour and in reducing the amount of blood loss when compared with those without cord drainage. The observed changes may be of clinical significance in reducing third stage related complications

Effect of gestational weight gain on pregnancy outcome of Indian mothers

Background: Gestational weight gain (GWG) and pre-pregnancy body mass index (BMI) play important roles in determining the pregnancy outcome. The weight gain recommendations by the IOM are based on Western WHO BMI cut-offs, making it difficult to generalize their findings to Asian Indians. We aimed to compare GWG among healthy pregnant women across different BMI with the IOM guidelines-2009. We also aimed to evaluate associated feto-maternal outcomes with GWG among the pregnant women enrolled in the study.Methods: A retrospective cohort study conducted at department of obstetrics and gynecology, from April 2019 to November 2019. Postnatal mothers whose weight was registered at first trimester of pregnancy and at term and delivered in SSG hospital were included. According to IOM Women were divided into: Group 1 less than recommended weight gain and Group 2 recommended weight gain.Results: Significant difference was seen in the baby weight between the two groups (p value 0.05), and no association was seen between GWG and preterm deliveries (p >0.05).Conclusions: Majority of patients in the both groups had term delivery. Women gaining less than recommended weight gain during pregnancy had new born with significantly lower birth weight. There was no association of mode of deliveries and GWG

Optical properties of CdS:Pb thin layer deposited on glass substrate

11-15The thermal evaporation technique has been used to deposit a polycrystalline cadmium lead sulphide thin film (Cd1-x PbxS with X=0.20) in a vacuum of about 10-5 Torr at 450 °C. This Cd1-x PbxS thin film has been investigated by X-ray diffraction technique. Optical constant like extinction coefficient (K), dielectric constant (€), and refractive index (n) have been measured from transmission spectrum in wavelength range from 700 nm to 1700 nm by manifacier’s envelope method. Crystallite size estimated from the Scherrer method has been found to be 31.25 nm. Coefficient of absorption (α) as well as film thickness (t) has been estimated by means of transmission spectra. The lattice parameter (a), dislocation density (δ), inter planner spacing (d), and micro strain (ε) have been calculated. X-ray study reveals that film stoichiometry is maintained in deposited film. The optical study confirms that optical band gap of Cd1-x PbxS film can be tuned from visible to near infrared region (2.42-1.20 eV) using relatively low cost technique. The red shift in optical band gap has been observed for Cd1-x PbxS thin film. Pb doping increase absorbance in visible region and near infrared region compared to undoped CdS film. The large decrease in band gap has been observed which makes the film much suitable for absorbing layer in solar cells, IR detector and other photovoltaic and optoelectronic applications. In film band, gap of 1.13 eV has been achieved which shows that doping of Pb in CdS makes it suitable material for solar cell absorber and IR detectors. The film shows high transmittance (about 70 %) in near infrared region. The film is polycrystalline and highly stoichiometric

Coronavirus Pathogenesis and the Emerging Pathogen Severe Acute Respiratory Syndrome

COVID-19, the ailment brought about by SARS-CoV-2, is an exceptionally infectious illness. The World Health Organization has proclaimed the progressing episode to be a worldwide general wellbeing crisis. Right now, the exploration of SARS-CoV-2 is in its essential stages. In view of the currently distributed proof, this audit methodically sums up the study of disease transmission, clinical attributes, findings, treatment, and anticipation of COVID-19. It is trusted that this survey will assist the general population in recognizing and managing SARS-CoV-2, and it will serve as a reference for future investigations

Optical properties of CdS:Pb thin layer deposited on glass substrate

The thermal evaporation technique has been used to deposit a polycrystalline cadmium lead sulphide thin film (Cd1-x PbxS with X=0.20) in a vacuum of about 10-5 Torr at 450 °C. This Cd1-x PbxS thin film has been investigated by X-ray diffraction technique. Optical constant like extinction coefficient (K), dielectric constant (€), and refractive index (n) have been measured from transmission spectrum in wavelength range from 700 nm to 1700 nm by manifacier’s envelope method. Crystallite size estimated from the Scherrer method has been found to be 31.25 nm. Coefficient of absorption (α) as well as film thickness (t) has been estimated by means of transmission spectra. The lattice parameter (a), dislocation density (δ), inter planner spacing (d), and micro strain (ε) have been calculated. X-ray study reveals that film stoichiometry is maintained in deposited film. The optical study confirms that optical band gap of Cd1-x PbxS film can be tuned from visible to near infrared region (2.42-1.20 eV) using relatively low cost technique. The red shift in optical band gap has been observed for Cd1-x PbxS thin film. Pb doping increase absorbance in visible region and near infrared region compared to undoped CdS film. The large decrease in band gap has been observed which makes the film much suitable for absorbing layer in solar cells, IR detector and other photovoltaic and optoelectronic applications. In film band, gap of 1.13 eV has been achieved which shows that doping of Pb in CdS makes it suitable material for solar cell absorber and IR detectors. The film shows high transmittance (about 70 %) in near infrared region. The film is polycrystalline and highly stoichiometric

“I’ve learnt from my experience and by my senior officers to face any challenge with a brave heart”: Lived experiences of Indian police community members during the pandemic

This qualitative study attempted to assess Indian police officers’ lived experiences of the pandemic and lockdown in the country. Sixteen participants (6 female and 10 male police officials) were interviewed. Data from the interviews was analyzed using thematic analysis. It was reported that several changes had occurred in the nature of the responsibilities that police personnel were expected to execute since the outbreak. Prior to it, the primary focus of the participants had been on management of crime. However, after the lockdown, the focus shifted to COVID-19 related duties. Three major sources of concern among police personnel were threat of acquiring the virus, of passing it on to family members and the attacks on policemen as they discharged their duties. Another important challenge was the adverse effects of increased job timings. Lack of proper sleep schedules due to emergency night shifts, increased job demands and mental burden led to feelings of exhaustion and fatigue. Within this scenario, family support and faith in God were reported to play a significant role in coping. Interestingly some police personnel also saw their work as adding a sense of purpose to their lives as they were engaged in protecting other people from the pandemic.

Exosomes: The Surreptitious Intercellular Messengers in the Body

Exosomes are secret intercellular messengers in the body, carrying crucial information from different organs. Different cargos can be packaged in exosomes including DNA, RNA, and proteins. The type of exosomal cargo can vary according to the tissue type, its pathophysiological state, and circadian rhythm. Therefore, exosomes have an immense potential to be utilized for diagnostic purposes if the conundrum of their cargo can be understood. Recent advances in exosome isolation and characterization have made it possible to define disease-specific cargo carried by these tiny messengers. We attempt to highlight disease-relevant exosomal cargos for diagnostic purposes

Intelligent Mobile Edge Computing Integrated with Blockchain Security Analysis for Millimetre-Wave Communication

 With the increase in number of devices enabled the Internet of Things (IoT) communication with the centralized cloud computing model. With the implementation of the cloud computing model leads to increased Quality of Service (QoS). The cloud computing model provides the edge computing technologies for the real-time application to achieve reliability and security. Edge computing is considered the extension of the cloud computing technology involved in transfer of the sensitive information in the cloud edge to increase the network security. The real-time data transmission realizes the interaction with the high frequency to derive improved network security. However, with edge computing server security is considered as sensitive privacy information maintenance. The information generated from the IoT devices are separated based on stored edge servers based on the service location. Edge computing data is separated based in edge servers for the guaranteed data integrity for the data loss and storage. Blockchain technologies are subjected to different security problem for the data integrity through integrated blockchain technologies. This paper developed a Voted Blockchain Elliptical Curve Cryptography (VBECC) model for the millimetre wave application. The examination of the blockchain model is evaluated based on the edge computing architecture. The VBECC model develop an architectural model based Blockchain technology with the voting scheme for the millimetre application. The estimated voting scheme computes the edge computing technologies for the estimation of features through ECC model. The VBECC model computes the security model for the data transmission in the edge computing-based millimetre application. The experimental analysis stated that VBECC model uses the data security model ~8% increased performance than the conventional technique

Molecular detection of plasmid mediated bla TEM, bla CTX−M,and bla SHV genes in Extended Spectrum β-Lactamase (ESBL) Escherichia coli from clinical samples

Abstract Background Extended spectrum β-lactamases (ESBLs) are a group of beta-lactamase enzymes that confer resistance to the oxyimino-cephalosporins and monobactams. The emergence of ESBL - producing genes possesses a serious threat for treating infections since it is associated with multi-drug resistance. This study was focused to identify the ESBLs producing genes from Escherichia coli isolates from clinical samples from a referral-level tertiary care hospital in Lalitpur. Methods This was a cross-sectional study conducted from September 2018 to April 2020 at the Microbiology Laboratory of Nepal Mediciti Hospital. Clinical samples were processed, and culture isolates were identified and characterized following standard microbiological techniques. An antibiotic susceptibility test was performed by a modified Kirby-Bauer disc diffusion method as recommended by Clinical and Laboratory Standard Institute guidelines.Extended -spectrum beta-lactamases were phenotypically confirmed by the combined disc method. The ESBL-producing genes bla TEM, bla CTX−M and bla SHV were confirmed by PCR. Results Of the 1449 total E. coli isolates, 22.29% (323/1449) isolates were multi-drug resistant (MDR). Among the total MDR E. coli isolates, 66.56% (215/323) were ESBL producers. The maximum number of ESBL E. coli was isolated from urine 90.23% (194) followed by sputum 5.58% (12), swab 2.32% (5), pus 0.93% (2), and blood 0.93% (2). The antibiotic susceptibility pattern of ESBL E. coli producers showed the highest sensitivity toward tigecycline (100%) followed by polymyxin b, colistin and meropenem. Out of 215 phenotypically confirmed ESBL E. coli, only 86.51% (186) isolates were found to be positive by PCR for either bla TEM or bla CTX−M genes. Among the ESBL genotypes, the most common were bla TEM 63.4% (118) followed by bla CTX−M 36.6% (68). Conclusion The emergence of MDR and ESBL – producing E. coli isolates with high antibiotic – resistant rates to commonly used antibiotics and increased predominance of major gene types bla TEM is a serious concern to the clinicians and microbiologists. Periodic monitoring of antibiotic susceptibility and associated genes would help guide the rationale use of antibiotics for treating the predominant pathogen E. coli in the hospitals and healthcare facilities of the communities