IMPACT OF PEER ASSISTED GALS LEARNING ON PRECISION IN CLINICAL DIAGNOSIS OF VARIOUS SPINAL DISORDERS

GALS screening examination is a simple, easily reproducible technique which requires minimal clinical instrument. This serves as effective tool in clinical diagnosis and assessment of various disorders. Spine Disorders forms integral part of Outdoor Patient Department (OPD) and Indoor patient department of Ayurvedic hospitals. They also forms integral part of various PG dissertations. Clinical diagnosis of spine disorder is very important. In spite of such enormous burden in OPD & IPD many times Ayurvedic students lack in diagnostic precision of various spinal disorders. Assistance of peer or teacher is very important in learning clinical skill. Aim of present study was to see impact of peer assisted GALS learning on precision in clinical diagnosis and assessment in interns and first year PG students.Total 15 students who were working in unit 3 of Kayachikitsa department were selected for training. 1 months peer assisted GALS skill training was given to them. They were assessed for precision in clinical diagnosis and confidence to diagnose with the help of confidence questionnaire and Final Objective structured clinical examination (OSCE) before and after training along with that open ended response also taken from them about the examination. Data was collected and analyzed based on observations and inference drawn. Peer assisted GALS learning improves clinical performance of students. GALS is a effective clinical tool in clinical diagnosis and assessment of various spinal disorders

A Brief Review of the Medicinally Important Indole Derivatives

Indole is an exceptional heterocyclic molecule with a broad spectrum of pharmacological activity owing to various modes of action. It is also a versatile pharmacophore and a favored scaffold. For drug development, it is an excellent moiety whose only characteristic is that it resembles many protein structures. Plenty of research has been taking place in recent years to synthesize and explore the various therapeutic prospective of this moiety. This review summarizes some of the recent effective chemical synthesis (2014-2018) for indole ring. Some of the most recent efficient chemical synthesis for the indole ring (from 2014 to 2018) is compiled in this review. The structure-activity relationship (SAR) was also given a lot of weight in this review in order to pinpoint the active pharmacophores of different indole analogues that have been the subject of studies for the past five years and are responsible for a variety of effects, including antiviral, antitubercular, anticancer, and anticonvulsant ones. The goals and framework of every research issue are explained in detail to help medicinal chemists have a deeper understanding of the circumstances contextually. Researchers will undoubtedly use this review as a platform to strategically design a variety of novel indole derivatives with lower toxicity and side effects and a range of intriguing pharmacological activit

An Insight on Analytical Profile on Bisoprolol Fumarate – A Selective Beta-1 Adrenoreceptor Blocker

BF is Beta-adreno receptor antagonist and used as an AntiHypertensive Drug. BF gives the blocking action on β1-adrenergic receptors in the heart and vascular smooth muscle. The present review compiles the various approaches implemented for quantification of BF in bulk drug, pharmaceutical matrix and biological fluid. This review represents more than 50 analytical methods which include capillary electrophoresis, HPLC, HPTLC, UV-Spectroscopy, UPLC, impurity profiling and electrochemical methods implemented for estimation of BF as a single component as well as in multicomponent

Equation of Craft in India

Description ‘Equation of Craft in India’ is a design research project of Craft Future Lab, NID Ahmedabad, India under the collaborative effort of the International Centre for Indian Craft (ICIC), Dept. of Lifestyle Accessory Design (LAD), and Design for Social Innovation and Sustainability Lab (NID DESIS Lab). The project was initiated and led by Prof. Amresh Panigrahi with his fellow 16 Master level Design students of the Department of LAD batch 2018 with the prime objective of attempting to understand the current dynamics in the Indian craft sector. The origin of crafts goes a long way back, to the Indus Valley civilization. It had its fair share of evolution through the centuries that followed from the Vedic, Mauryan, Mughal periods to the British colonization and the onset of industrialization. The crafts of India have gone through several impactful events with our relatively newfound Independent democratic country and its political and economic development. The current context of craft in the 20th century takes into account the social, economic and geopolitical setting of India with the presence of various global developments in technology, import-export scenario, travel and popular mass ideas. Here the System mapping is an attempt to represent the identified components and variables and interrelationship within the current system understanding of the craft sector in India. Craft in its essence Craft is a vital source of identity for the craftsman as it derived its meaning by its local acceptance in its socio-cultural fabric. It has developed through a long line of rich cultural heritage. The function of crafts varies from being utilitarian, ornamental to finding purposes in religious, ritualistic, and festival purposes. Crafts now are much more susceptible to cross-cultural influences of the increasing spread of media, the internet, and education. The Development Commissioner of Handicrafts (DCH), India defined crafts as ‘items made by hand, often with the use of simple tools and generally artistic and traditional. They include objects of utility and objects of decoration’. The three main confluence for the creation of a craft comes with (a) an artisan along with his ability working on (b) the raw materials with a little help from the (c) simple tools that aids where human abilities limit him. The craftsmen and the craft dynamics The four significant divisions of craftsmen based on their ability are – Master-craftsmen, Craftsmen, Apprentice, and newly joined. Master-craftsmen display the highest skill and bring novelty in the craft. Apart from the newly joined category of artisans, all other craftsmen majorly learn the craft from the master craftsperson or from within the family itself, passed down through the generations. It is a labour-intensive sector where artisans get less return in terms of money, recognition, value for craft for the much more investment they put into it. The investment may be in terms of effort, time, and the number of workforces. The real success of a craft is no more confined to the ability of the craftsperson’s skills, raw material and tools. It is the time that demands the market knowledge to make the craft a success. However, the craftsman abilities are currently limited with less market knowledge and mostly restricted to the boundaries of his craft understanding. Lack of knowledge, their struggle with the craft practices and its continuity became much more complicated, which forced them to switch to other jobs or to want a different life for their children. Initiatives at organising the sector The craft & cottage industry is the most significant non-agricultural decentralized sector of the Indian economy. In the wake of the government’s attempt to organize the sector and tap into its full potential, it works on multiple value chains of the craft sector. The government provides market platforms through multiple exhibitions, Haats, fairs and emporiums, wherein efforts are put into making the customer realize the cultural context of the craft. One of the major competitors in the market remains to be the mass-produced industrialized products flooding in domestically and also via imports from other neighbouring countries. Domestically, authentic craft loses its market to mass-produced fake craft due to its comfortable, cheaper availability. Protection of crafts ingenuity The fake market affected the craftsmen and the identity of the craft which led to government initiatives aimed at creating protection and preservation of craft’s ingenuity owing to the craftsmen and its community through the creation of geographical indication (GI) tag, Craftmark logo and also through handicraft census. With over 200 crafts GI tagged, it is beneficial to the owners as they can safeguard their products from unauthorized commercial use. Presence of the GI tag has still left some room for improvements for craftsman’s awareness and fight for their rights. The Craftmark logo is an initiative to provide a mark for genuine handicraft for the consumers to authenticate their purchase. Private exhibitions and museums purposefully created for documentation and preservation of the handicrafts. Role of design in craft innovation With above systematic study, the working groups further discovered various gaps as an opportunity for design-driven strategic intervention. Practice-based Design research facilitates the application of design strategies at various levels to imagine a craft social innovation and its sustainable future

Design of experiment avenue for development and validation of RP-HPLC-PDA method for determination of apremilast in bulk and in in-house tablet formulation

Abstract Background Apremilast is phosphodiesterase-4 and an immunomodulating agent used for treatment of refractory psoriatic arthritis. Methods The reversed-phase high-performance liquid-chromatography method for analysis of apremilast was developed and validated as per ICH guidelines. The separation of apremilast was performed on PrincetonSPHERE Ultima C18 column (250 mm × 4.6 mm, i.d., 5 μm particle size) with photodiode array detection carried out at 231 nm. A Box–Behnken design with response surface methodology was executed out for optimization of chromatographic conditions of reversed-phase high-performance liquid-chromatography for finished desired chromatographic separation of apremilast from its formulation with less number of experimental trials. Three independent factors, namely methanol composition in the mobile phase, pH of an aqueous phase, and flow rate, were used to construct a mathematical model and study the effects of these independent factors on responses such as retention time, theoretical plates, and tailing factor. Results Optimized experimental conditions for proposed work consists of methanol and water, pH 3.50 adjusted with ortho-phosphoric acid (70:30 % v/v) as a mobile phase at a flow rate 1 ml/min with a retention time was found to be 5.15 min. Accuracy study was completed at three different levels and was found in the range of 99.44–101.49%. Conclusion The 3D response surface graphs revealed that the methanol composition and pH of an aqueous phase were both most stringent factors affecting the responses. Thus, a new, precise, and accurate HPLC method was developed and validated and can be used for regular analysis of apremilast

INVESTIGATION OF MECHANICAL PROPERTY OF VARIOUS MIX DESIGN IN CONCRETE BY REPLACING FINE SAND WITH FOUNDRY SAND

Nowadays, concrete become most widely used material in construction. The demand of concrete increases day by day. Other way, Foundry sand is the byproduct of Ferrous and Non-Ferrous metal casting foundries where the river sand is used many times for the core and mould production with the binders. After a time these sand become unusual for the core production n called waste foundry sand. In this research paper, replacement of fine sand of concrete is done with the foundry sand, so the disposal problem related with the foundries have to be reduce so minor environmental issues create and the cost of concrete also reduced so with the increase in the strength of concrete by using foundry sand in it. Mix design of M30 and M25 were adopted for the replacement of fine sand. The fine sand has been replaced by foundry sand accordingly at replacement of 10%, 20% & 30% by weight for M-30 and M-25 Grade concrete. Concrete mixtures were produced, tested and compared in terms of different strength and different grade with the conventional concrete. Testing of these samples were carried out to calculate the Compressive strength for 7, 14 and 28 days. As a result, the compressive increased up to 20% addition of used foundry sand in M-30 grade and for M-25 the strength increment noticed at 1% replacement. This research work is anxious with experimental investigation on strength of concrete and optimum percentage of the partial replacement of foundry sand by replacing fine aggregate via 10%, 20%, and 30% with M30 and M-25 Grade. Keeping all this view, the aim of investigation is the behavior of concrete while adding of waste foundry sand with various proportions of various mix in concrete by replacing fine sand using tests on various strength

UV-Spectrophotometry - Multicomponent Mode of Analysis for Simultaneous Estimation of Brinzolamide and Brimonidine Tartrate in Bulk and Ophthalmic Formulation

Brinzolamide (BRZ) and Brimonidine Tartrate (BT) in combination are available as an ophthalmic suspension in the ratio of 5:1. A simple, reproducible and efficient method for the simultaneous determination of BRZ and BT in Bulk and Ophthalmic formulation has been developed. The absorbance was assessed at two wavelengths i.e. 252.40 nm (λ max of BRZ) and 246 nm (λmax of BT) in methanol. In this method, BRZ and BT executed linearity in the concentration range of 5-35 μg/mL and 3-18 μg/mL, respectively at their respective λ max. The developed method was found to be accurate, precise and rugged as marked by small values of % RSD according to ICH guidelines

Temperature control of shell & tube type Heat exchanger By using Twin CAT PLC

Abstract:-In many industrial process and operations Heat Exchanger is one of the important unit for the transfer of thermal energy. There are different types of heat exchangers used in industries, the shell and tube type heat exchanger is most common. The main purpose of heat exchanger is to maintain fluid at specific temperature conditions, which is achieved by controlling the exit temperature of one of the fluids. Here we have presented an automation system that is composed of Heat exchanger, Twin CAT PLC and sensors. To control the tube outlet temperature of the fluid of heat exchanger system Twin CAT PLC used. The designed controller regulates the shell outlet temperature of the fluid to a desired set point in the shortest possible time.SCADA system is used to give a virtual display of the proposed process. The end system is a fully automated for the transfer of energy in industrial applications