Design and Evaluation of Topical Hydrogel Formulation of Aceclofenac for Improved Therapy

Aceclofenac, a non-steroidal anti-inflammatory drug has been used in the treatment of rheumatoid arthritis and osteoarthritis. In order to decrease the gastric ulcerogenic effects, aceclofenac hydrogel have been developed. Topical gel preparations are intended for skin application or to certain mucosal surfaces for local action or transdermal penetration of medicament or for their emollient or protective action. Topical delivery of drugs can be achieved by incorporating drug into the gel matrix for effective delivery of drugs, thus avoiding first pass metabolism and for increased local action in pain management and skin diseases. NSAID’s are non-steroidal drugs having excellent anti-inflammatory and analgesic activity but NSAID’s produces GIT ulceration, liver and kidney trouble especially in case of oral administration. In view of adverse drug reaction associated with oral formulations, many NSAID’s are increasingly administered by topical route. Hydrophilic polymers like Guar gum and Carbopol 940 of varying concentrations were used in an attempt to develop topical hydrogel formulations of aceclofenac. Evaluation tests for visual appearance, pH, viscosity, spreadability, assay, in vitro drug release were carried out. In vitro diffusion study was carried out in a Franz diffusion cell using cellophane membrane. No prominent changes in physicochemical properties of formulation were observed after exposure to accelerated conditions of temperature (40 ± 2oC) and humidity conditions (75 ± 5%RH). The gel formulation consisting of 1% w/v Guar gum 1% w/v Carbopol 940 at 1:1 ratio was found to be suitable for topical application based on in vitro evaluation. These results suggest the feasibility of the topical gel formulation of aceclofenac. Keywords: Aceclofenac, Guar gum, Carbopol 940, Topical hydrogel, Franz diffusion cel

A REVIEW OF ANALYTICAL TECHNIQUES FOR DETERMINATION OF ANTI-HIV DRUGS

Pharmaceutical analysis plays a very prominent role in quality assurance as well as quality control of bulk drugs and pharmaceutical formulations. Rapid increase in pharmaceutical industries and production of drug in various parts of the world has brought a rise in demand for new analytical techniques in the pharmaceutical industries. As a consequence, analytical method development has become the basic activity of analysis. From the times of yore, people were trying to find safe and sound ways to treat viral infections. In the current scenario, due to the emerging of new viruses, the development of drugs for their treatment is also gaining equal importance. Before launching to the market, these drugs should undergo a validation process. High-performance liquid chromatography (HPLC) coupled with ultraviolet (UV), Photodiode array detectors (PDA), Mass spectrophotometer (MS) detectors etc. is one of the fastest, safe and precise technologies used for determination and separation of pharmaceutical drugs, impurities and biological samples. HPLC is versatile and it takes less time for quantification of drugs as compared to old liquid chromatography techniques. Tenofovir disoproxil fumarate (TDF), Emtricitabine (FTC) and Efavirenz (EFV) is antiretroviral medicine used treat AIDS as well as chronic Hepatitis-B. It is used alone or with other HIV medications to help control HIV infection. The present review article assesses the published analytical methods and a variety of approach for investigation of TDF, FTC and EFV in bulk drug as well as pharmaceutical formulations including combinations. The present studies revealed that HPLC technique along with the spectroscopic have been most widely explored for the analysis. The investigatory review may provide the comprehensive details to the researchers who are working in the area of analytical research of TDF, FTC and EFV

POOR SOLUBILITY OF DRUG AND ITS FORMULATION: A REVIEW

This present paper discusses about the poor solubility of drug as a major challenge for drug formulation companies and researchers. Further, its various aspects and researchers’ perspective and future work through the review’s studies of past and current

A comprehensive investigation on development of lightweight aluminium miniature gears by thermoelectric erosion machining process

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