Studies on Vishada Guna of Vata Dosha and validation of its assessment criteria

Vata possesses the Vishada property which is assessed through its action of Kleda Achusan and Ropan. Action of Vishada Guna of Vata Dosha is Kshalana Karma. The causative factor for Medavaha Srota Dushti is Avyam, Diva Swapno, Meda Bhakshan and Varuni Ati Seban. Objectives of the study was to evaluate the etymological and syntactical derivation of the Guna of Vata Dosha, to evaluate the biophysical and molecular basis of the Vishada Guna. The study was conducted over 25 healthy volunteers (16 -70 years) who had the Dhatu Samya Lakshanas and 25 patients having the Meda Kshaya Lakshans. The healthy volunteers (Group-A) were taken under the control group for the assessment and standardization of the normal value of IL-1, IL-8 and TNF-α in the blood. Group-A with normal level of IL-1, IL-2 and TNF-α signify a specific range of objective parameters i.e. the activity of RE system with Dhatu Samya Lakshanas in healthy volunteers.  Group-B the same objective parameters were recorded of the patients presenting with the Sandhi Sphutan, as a characteristic of Meda Kshaya Lakshana. Significant increase in the blood level of IL-1, IL-8 and TNF-α in comparison to healthy personality reveals that aggravation of Vishada Guna causes Kshalana Karma reflecting Sandhi Sphutan. Hence, those three parameters may be significant criteria for the assessment of Sandhi Sphutan

STUDIES ON RUKSHA GUNA OF VATA DOSHA AND VALIDATION OF ITS ASSESSMENT CRITERIA

Guna (attribute) is one of the causes for the efficacy of any substance and is inseparable concomitance with substance. Ruksha guna is one of the Vata gunas perform the action of Dosha soshana karma (absorption). In broad perspective Soshana karma may be taken as the exchange of various materials in between the cell and respective environment. No study in context to the assessment of Ruksha guna has yet been carried out in modern perspective in the field of Ayurveda. The present study, was planned to evaluate the etymological and syntactical derivation of the Guna of Vata dosha, the biophysical and molecular basis of the Ruksha guna. and to validate the assessment criteria of Ruksha guna. For the assessment of Ruksha guna, observed the relative changes in the skin pH and skin moister with the level of vascular osmolality. These parameters are indicators of skin hydration in both healthy (with Dhatu samya lakshana) and Twaka rukahata condition (as patient with Rakta kshaya lakahana). Comparing the relation of skin pH and skin hydration along with vascular osmolality in both group to reveal the relation between osmolality and Rukstwa (roughness) the study was conducted. The study concluded that Ruksha guna of Vata dosha is critical requirement to make cell alive or to sustain the cellular homeostasis by its absorption and transport mechanism. Rakta kshaya may be correlated with decrease in the amount of circulatory hemoglobin in plasma. Rukshatwa therefore correlate with plasma osmolality and assessed by skin pH and hydration

A CRITICAL STUDY ON KARYA- KARAN VADA IN RELATION TO GRAM NEGATIVE MICRO-ORGANISM IN UTI

The doctrine of cause & effect (Karya-Karana Vada) is well versed and common in ancient Indian Philosophy Sankhya Darsana which is clinically adopted in Ayurveda. Karya-Karana Sidhanta is applicable for both Swastha and Vikara avastha. Therefore the study was conducted to evaluate the critical doctrine of Cause and Effect in the light of its clinical entity, and the efficacy of Padma (Nelumbium speciousum Willd), Priyangu (Callicarpa macrophylla Vahi) and Agnimantha (Premna intergrifolia Linn) on gram negative organisms to establish the stipulated doctrine i.e. Karya-Karana Vada. This was a in-vitro study conducted on the microorganisms causing UTI commonly E. coli sp. and Klebsiella sp. The Bacteria Escherichi colli species and Klebsiella species were collected separately from the stock culture of Pathology Laboratory. Crude and Sterile Plant extract of above plant are used for the study. The crude and the sterile extract of the selected plants named Padma, Priyangu and Agnimantha are effective to inhibit the zone of colonisation of E.coli & Klebsiella in varying degree. These studies were performed in triplicate. This study concluded that micro organism enter into the bladder and kidney through urethra or any others means, they multiply in urine and change urine pH, causes Urinary Tract Infection. The responsible above said two gram negative micro-organism may or may not produce UTI, it depends upon the potentiality causative factors as justified in the doctrine of Cause and Effect (Karya-Karana Vada), and above mention three herbs shows significant anti microbial activities