Nonlinear Effects Caused by Coupling Misalignment in Rotors Equipped with Journal Bearings

Misalignment is one of the most common sources of trouble of rotating machinery when rigid couplings connect the shafts. Ideal alignment of the shafts is difficult to be obtained and rotors may present angular and/or parallel misalignment (defined also as radial misalignment or offset). During a complete shaft revolution, a periodical change of the bearings load occurs in hyperstatic shaft-lines, if coupling misalignment between the shafts is excessive. If the rotating machine is equipped with fluid-film journal bearings, the change of the loads on the bearing causes also the variation of their instantaneous dynamic characteristics, i.e. damping and stiffness, and the complete system cannot be considered any longer as linear. Despite misalignment is often observed in the practice, there are relatively few studies about this phenomenon in literature and their results are sometimes conflicting. The authors aim at modeling accurately this phenomenon, for the first time in this paper, and giving pertinent diagnostic information. The proposed method is suitable for every type of shaft-line supported by journal bearings. A finite element model is used for the hyperstatic shaft-line, while bearing characteristics are calculated by integrating Reynolds equation as a function of the instantaneous load acting on the bearings, caused also by the coupling misalignment. The results obtained by applying the proposed method are shown by means of the simulation, in the time domain, of the dynamical response of a hyperstatic shaft-line. Nonlinear effects are highlighted and the spectral components of the system response are analyzed, in order to give diagnostic information about the signature of this type of fault

Squeeze Film Damper Modeling: A Comprehensive Approach

Squeeze film dampers (SFDs) are components used in many industrial applications, ranging from turbochargers to jet engines. SFDs are applied when the vibration levels or some instability threatens the safe operation of the machine. However, modeling these components is difficult and somewhat counterintuitive due to the multiple complex phenomena involved. After a thorough investigation of the state of the art, the most relevant phenomena for the characterization of the SFDs are highlighted. Among them, oil film cavitation, air ingestion, and inertia are investigated and modeled. The paper then introduces a numerical model based on the Reynolds equation, discretized with the finite difference method. Different boundary conditions for oil feeding and discharging are implemented and investigated. The model is validated by means of experimental results available in the literature, whereas different designs and configurations of the feeding and sealing system are considered. Eventually, an example of the application of a SFD to a compressor rotor for the reduction of vibration and correction of the instability is proposed. The paper provides an insight regarding the critical aspects of modeling SFDs, underscoring the limits of the numerical model, and suggesting where to further develop and improve the modeling

Beyond capitalist enclosure, commodification and alienation. Postcapitalist praxis as commons, social production and useful doing

This paper aims to further a geographical agenda through the concept of postcapitalism. We outline its contours across three terrains of transformation between capitalism and postcapitalism: creating commons against enclosure; socially useful production that counters commodification; and, joyful doing that negates alienated work. Secondly, we explore how postcapitalism is mobilised with different inflections through three contemporary debates: community economies, post-work and autonomous perspectives. We then illuminate how one area of social practice (platform cooperatives) resonates with postcapitalist terrains and debates. We conclude by exploring the, as yet unclear and partially formed, social and spatial landscape of postcapitalism

Analysis of the periodic breathing of a transverse annular crack propagated in a real rotating machine

This paper shows the numerical results of a model-based analysis carried out to investigate the experimental dynamic behaviour of the shaft of a real steam turbine in which a deep annular – or circumferential – crack propagated. The shape of this transverse crack was caused by the generation of multiple initiation points, equally spaced over the whole circumferential surface of the shaft cross-section located at the first high pressure stage of the steam turbine. The periodic breathing of the crack caused changes in the area moments of inertia of the damaged cross-section and fault symptoms. Conversely, the shaft heating that affected the turbine during the load rises performed at the end of the runups carried out from a cold state pointed out an abnormal sensitivity of the synchronous vibrations to the machine thermal state. As a result, the fault symptoms caused by this crack were quite different from those induced by common shaft transverse cracks. The breathing of this crack, caused by gravity, has been studied by means of a mathematical model in order to investigate the influence of the crack opening and closure on the harmonic content of the turbine vibration. A new approach is used in this paper, considering a more appropriate 3D FE model that allowed the non-linear distribution of the stresses in the cracked section to be estimated. The method used for the present study has proved that the non-linear distribution of the axial stresses in the area close to the crack tip gives only minor effects on the breathing mechanism. This is an original contribution, which could have not been observed in previous authors' papers that employed simplified models for the periodic breathing. The good accordance between numerical results and experimental data confirms the adequacy of the investigation method used for this study. With reference to diagnostic purposes, this involves that the early on-line detection of annular cracks propagated in the shafts of rotating machinery needs to use more accurate techniques, based on the analysis of vibration data, which can point out fault symptoms, even in the case of very deep transverse cracks

Peptidylarginine Deiminases Post-Translationally Deiminate Prohibitin and Modulate Extracellular Vesicle Release and MicroRNAs in Glioblastoma Multiforme.

Glioblastoma multiforme (GBM) is the most aggressive form of adult primary malignant brain tumour with poor prognosis. Extracellular vesicles (EVs) are a key-mediator through which GBM cells promote a pro-oncogenic microenvironment. Peptidylarginine deiminases (PADs), which catalyze the post-translational protein deimination of target proteins, are implicated in cancer, including via EV modulation. Pan-PAD inhibitor Cl-amidine affected EV release from GBM cells, and EV related microRNA cargo, with reduced pro-oncogenic microRNA21 and increased anti-oncogenic microRNA126, also in combinatory treatment with the chemotherapeutic agent temozolomide (TMZ). The GBM cell lines under study, LN18 and LN229, differed in PAD2, PAD3 and PAD4 isozyme expression. Various cytoskeletal, nuclear and mitochondrial proteins were identified to be deiminated in GBM, including prohibitin (PHB), a key protein in mitochondrial integrity and also involved in chemo-resistance. Post-translational deimination of PHB, and PHB protein levels, were reduced after 1 h treatment with pan-PAD inhibitor Cl-amidine in GBM cells. Histone H3 deimination was also reduced following Cl-amidine treatment. Multifaceted roles for PADs on EV-mediated pathways, as well as deimination of mitochondrial, nuclear and invadopodia related proteins, highlight PADs as novel targets for modulating GBM tumour communication

Diagramming social practice theory:An interdisciplinary experiment exploring practices as networks

Achieving a transition to a low-carbon energy system is now widely recognised as a key challenge facing humanity. To date, the vast majority of research addressing this challenge has been conducted within the disciplines of science, engineering and economics utilising quantitative and modelling techniques. However, there is growing awareness that meeting energy challenges requires fundamentally socio-technical solutions and that the social sciences have an important role to play. This is an interdisciplinary challenge but, to date, there remain very few explorations of, or reflections on, interdisciplinary energy research in practice. This paper seeks to change that by reporting on an interdisciplinary experiment to build new models of energy demand on the basis of cutting-edge social science understandings. The process encouraged the social scientists to communicate their ideas more simply, whilst allowing engineers to think critically about the embedded assumptions in their models in relation to society and social change. To do this, the paper uses a particular set of theoretical approaches to energy use behaviour known collectively as social practice theory (SPT) - and explores the potential of more quantitative forms of network analysis to provide a formal framework by means of which to diagram and visualize practices. The aim of this is to gain insight into the relationships between the elements of a practice, so increasing the ultimate understanding of how practices operate. Graphs of practice networks are populated based on new empirical data drawn from a survey of different types (or variants) of laundry practice. The resulting practice networks are analysed to reveal characteristics of elements and variants of practice, such as which elements could be considered core to the practice, or how elements between variants overlap, or can be shared. This promises insights into energy intensity, flexibility and the rootedness of practices (i.e. how entrenched/ established they are) and so opens up new questions and possibilities for intervention. The novelty of this approach is that it allows practice data to be represented graphically using a quantitative format without being overly reductive. Its usefulness is that it is readily applied to large datasets, provides the capacity to interpret social practices in new ways, and serves to open up potential links with energy modeling. More broadly, a significant dimension of novelty has been the interdisciplinary approach, radically different to that normally seen in energy research. This paper is relevant to a broad audience of social scientists and engineers interested in integrating social practices with energy engineering

Resourcing Scholar-Activism: Collaboration, Transformation, and the Production of Knowledge

In this article we offer a set of resources for scholar-activists to reflect on and guide their practice. We begin by suggesting that research questions should be triangulated to consider not only their scholarly merit but the intellectual and political projects the findings will advance and the research questions of interest to community and social movement collaborators

Cannabidiol Affects Extracellular Vesicle Release, miR21 and miR126, and Reduces Prohibitin Protein in Glioblastoma Multiforme Cells

Glioblastoma multiforme (GBM) is the most common and aggressive form of primary malignant brain tumor in adults, with poor prognosis. Extracellular vesicles (EVs) are key-mediators for cellular communication through transfer of proteins and genetic material. Cancers, such as GBM, use EV release for drug-efflux, pro-oncogenic signaling, invasion and immunosuppression; thus the modulation of EV release and cargo is of considerable clinical relevance. As EV-inhibitors have been shown to increase sensitivity of cancer cells to chemotherapy, and we recently showed that cannabidiol (CBD) is such an EV-modulator, we investigated whether CBD affects EV profile in GBM cells in the presence and absence of temozolomide (TMZ). Compared to controls, CBD-treated cells released EVs containing lower levels of pro-oncogenic miR21 and increased levels of anti-oncogenic miR126; these effects were greater than with TMZ alone. In addition, prohibitin (PHB), a multifunctional protein with mitochondrial protective properties and chemoresistant functions, was reduced in GBM cells following 1 h CBD treatment. This data suggests that CBD may, via modulation of EVs and PHB, act as an adjunct to enhance treatment efficacy in GBM, supporting evidence for efficacy of cannabinoids in GBM