The use of non-human primates in research

The use of non-human primates in biomedical research is a contentious issue that raises serious ethical and practical concerns. In the European Union, where regulations on their use are very tight, the number of non-human primates used in research has been in decline over the past decade. However, this decline has been paralleled by an increase in numbers used elsewhere in the world, with less regard for some of the ethical issues (e.g. genetic manipulations). There is evidence that researchers from high-income countries (HICs), where regulations on the use of non-human primates are strict, may be tempted to conduct some of their experiments in countries where regulation is less strict, through new collaborative efforts. In collaborative ventures, equivalence in the application of ethical standards in animal research, regardless of location, is necessary to avoid this exploitatio

Traditional and Complementary Medicine: Analysing Ethical Challenges

The use of traditional and complementary medicines (T&CMs) is both ubiquitous in low and middle income countries and highly contested in some sections of high income countries. Whilst T&CMs are promoted as an accessible and affordable health care system by high level health policy makers (for example, the Director General of the World Health Organization), their use is simultaneously indicted as a waste of resources, non-scientific, and unethical. The aim of this thesis is to provide a calm, considered and well researched view on a highly emotional topic: What is the nature of the ethical challenges for the use and practice of TCMs and how might they be addressed? The methodology chosen for the ambitious topic of this thesis is the Ethical Matrix as developed by Ben Mepham in the UK in the 1990s. It is founded upon a principlist approach to ethical analysis and has been used widely in decision-making for new technologies. It requires the consideration of interests of stakeholders including, but also beyond, human beings. For the purpose of this thesis four groups were selected: human users of T&CM, the environment, animals, and low and middle income countries (LMICs). Ethical analysis reveals that: • Most ethical concerns associated with T&CMs are related to safety issues for human users; • there are also serious concerns about the way in which animals are routinely harmed through use in T&CM products and T&CM research; • the production and use of some T&CMs does have damaging impacts upon the environment and, • the ethical challenges associated with the use of T&CM in LMICs are different from those in high income countries. Based on the analysis, the thesis provides clear steps to be taken to reduce the potential for harm from both adverse drug reactions and adverse events for humans as well as recommendations to reduce the harm to animals and the environment from use of T&CMs

Innovating Responsibly in ICT for Ageing: Drivers, Obstacles and Implementation

Responsible research and innovation (RRI) is a nascent concept, promoted actively by the European Union and other policy makers around the world. Hitherto, this concept has been associated primarily with publicly funded activities but given the considerable proportion of research and innovation that is undertaken in the private sector, RRI will be rendered irrelevant unless it is adopted by industry. This paper introduces a private sector perspective of RRI, specifically that of the information and communication technology (ICT) industry, working in the field of healthy ageing. Drawing upon empirical data from 30 in-depth interviews with key industry representatives from across Europe, it explores: (a) the level of awareness of RRI; (b) the drivers and obstacles influencing its implementation; and (c) the factors deemed vital for facilitation of RRI in industry. The findings paint a varied picture, including significant concerns about adoption of RRI in an industry environment where the economic implications of all activities must be considered carefully. However, some companies have found their own ways to balance financial and altruistic goals, suggesting that there is both a willingness and a place for an RRI-type governance framework within the private sector

‘I should do what?’ Addressing research misconduct through values alignment

Evidence suggests that the incidence of research misconduct is not in decline despite efforts to improve awareness, education and governance mechanisms. Two responses to this problem are favoured: first, the promotion of an agent-centred ethics approach to enhance researchers’ personal responsibility and accountability, and second, a change in research culture to relieve perceived pressures to engage in misconduct. This article discusses the challenges for both responses and explains how normative coherence through values alignment might assist. We argue that research integrity and research ethics convey mixed messages, which are likely to contribute to a form of normative confusion. For the successful adoption of an agent-centred approach, normative coherence is needed between the two. To facilitate normative coherence, we propose that research ethics and research integrity be underpinned by a shared set of moral values that can be enacted via codes and guidelines and imbue research environments. Furthermore, to facilitate culture change, the same normative coherence is necessary at all levels of an institution. Only via values alignment between institutional aims, management, institutional practices and researchers can an ethical culture become truly embedded in research institutions

Applying an Ethical Framework to Herbal Medicine

Herbal medicines make a vital contribution to healthcare globally, but from production through to practice, there are ethical challenges that require attention. Ethical challenges are often analysed through application of an ethical framework because this can facilitate a consistent and structured approach. In healthcare, the most commonly used framework over recent decades has been that of the four principles: beneficence, nonmaleficence, autonomy, and justice. However, for various reasons that are explained, this approach to ethical analysis is not the most fitting for the global phenomenon of herbal medicine. In this paper, a relatively new moral framework that is based upon the globally accepted values of care, respect, honesty, and fairness is explored in relation to herbal medicine for the first time. Through application of this framework, the ethical challenges and actions needed to address them become clear, thus resulting in practical recommendations for enhancing ethical standards in herbal medicine

An Investigation into Risk Perception in the ICT Industry as a Core Component of Responsible Research and Innovation

This paper makes an original contribution to the responsible research and innovation (RRI) discourse, with an inquiry into the extent to which risk, risk assessment, or risk management, including ethical and social issues, is relevant to companies. As a core component of the higher or “meta-responsibility” of RRI, an investigation of practices and attitudes towards risks can provide us with a window into companies’ attitudes towards responsible innovation that is rooted in realworld experiences. Drawing upon data from 30 in-depth interviews and a large Delphi study, we reveal different underlying attitudes towards risk governance for individuals working in the information and communication technology (ICT) industry. For some companies, there is already an obvious degree of alignment with RRI values. For others, framing of the RRI discourse in terms of ethical and societal risks may help to promote understanding and uptake. Results from the interviews suggest that lack of awareness of the full extent of ethical and societal risks associated with research and innovation in the ICT industry may act as a barrier to engagement with RRI, and educational activities may be needed to rectify this situation. Results from the Delphi survey suggest that when presented with simple information about potential ethical and societal risks, industry personnel can easily recognise the main risks and provide clear opinions about how they should be addressed. The relationship between risk governance and RRI warrants further investigation as it is an essential facet of RRI

The Responsible Research and Innovation (RRI) Maturity Model: Linking Theory and Practice

Responsible research and innovation (RRI) is an approach to research and innovation governance aiming to ensure that research purpose, process and outcomes are acceptable, sustainable and even desirable. In order to achieve this ambitious aim, RRI must be relevant to research and innovation in industry. In this paper, we discuss a way of understanding and representing RRI that resonates with private companies and lends itself to practical implementation and action. We propose the development of an RRI maturity model in the tradition of other well-established maturity models, linked with a corporate research and development (R&D) process. The foundations of this model lie in the discourse surrounding RRI and selected maturity models from other domains as well as the results of extensive empirical investigation. The model was tested in three industry environments and insights from these case studies show the model to be viable and useful in corporate innovation processes. With this approach, we aim to inspire further research and evaluation of the proposed maturity model as a tool for facilitating the integration of RRI in corporate management

Ethics Dumping – How not to do research in resource-poor settings

Ethics dumping is a global phenomenon involving the ‘off-shoring’of research. Research that would be prohibited, severely restrictedor regarded as highly patronizing in high-income regions is instead conducted inresource-poor settings. Twenty-eight case studies of ethics dumping were examined through inductive thematic analysis to reveal predisposing factors from the perspective of researchers from high-income regions. Six categories were agreed and further illuminated: Patronizing conduct, unfair distribution of benefits and/or burdens, culturally inappropriate conduct, double standards, lack of due diligence and lack of transparency. The ultimate aim of the paper is to deepen understanding of thesehighly unethical practicesamongst academics who stand against poverty, leading to theirfurther reduction

Working together to make the world a healthier place: Desiderata for the pharmaceutical industry

Cross-sectorial, dynamic, and innovative partnerships are essential to resolve the challenges of humankind in the 21st century. At the same time, trust in each other’s integrity and good will is a precondition for the solution of any complex problem, and certainly for the success of the United Nations Sustainable Development Agenda. Experience shows that a nation’s economic and social success is at its greatest if, and when, there is cooperation and even cocreation involving a fair division of labor and responsibility among the different societal stakeholders. This paper uses Ralf Dahrendorf’s seminal work on obligations, as well as the European Commission’s Science with and for Society unit’s definition of responsible research and innovation (RRI), to motivate industry responsibilities to make the world a healthier place

Bedside teaching during the COVID‐19 pandemic

The impact of the SARS‐CoV‐2 (COVID‐19) pandemic on medical education is well described. Here, we describe an aspect that has received little attention so far, namely the ethical implications of continued bedside teaching. As a team of clinical educators supported by one of our students and an ethicist, we describe this unexpected challenge and how we navigated it in an already existing sea of COVID‐induced issues and uncertainty