In Vitro Anti-Staphylococcal Activity of Alkaloids from the Leaves of Callestimone Rigidus R.Br

Multidrug resistant Staphylococcus aureus poses a severe global threat worldwide due to their prevalence, genomic plasticity and limited therapeutic options being refractory to most antibiotic classes. This necessitates the discovery of new anti-staphylococcal interventions. Callistemon rigidus R.Br. (Myrtaceae) has been found to possess antibacterial potential against clinical isolates. Thied me study was a isolate and evaluate the antibacterial alkaloids from the leaves of Callistemon rigidus and assess their in vitro anti-staphylococcal potential. Alkaloid isolation was carried out by modiied method for plant alkaloid extraction. The in vitro anti-staphylococcal potential of the alkaloid bioactive fraction was assessed by using micro broth dilution and plate count assay methods. Pus and wound isolates had MIC of 80 µg/mL and 50 IC of 27.22 µg/mL respectively. Burn isolates showed MIC of 320 µg/mL and 50 50 13.57 µg/mL respectively. Urine and vaginal isolates exhibited a MIC of 80 µg/mL 50 and IC of 13.15 µg/mL respectively. Ceixime had MIC values was 320 µg/mL, 160 50 50 µg/mL and 160 µg/mL for pus and wound, burn, urine and vaginal isolates indicating the refractory behaviour when compared to alkaloid bioactive fraction from the leaves of Callistemon. The alkaloid bioactive fraction exhibits immense activity compared to standard antibiotic Ceixime. This work is the irst report of alkaloids and their antimicrobial activity from Callistemon rigidus leaves. The results suggest further isolation of individual alkaloids from alkaloid bioactive fraction and assessment their anti-staphylococcal activity as leads for development of anti-staphylococcal drugs

Reaction Time of a Group of Physics Students

The reaction time of a group of students majoring in Physics is reported here. Strong co-relation between fatigue, reaction time and performance have been seen and may be useful for academicians and administrators responsible of working out time-tables, course structures, students counsellings etc.Comment: 10 pages, 4 figure

Hindi Digits Recognition System on Speech Data Collected in Different Natural Noise Environments

This paper presents a baseline digits speech recognizer for Hindi language. The recording environment is different for all speakers, since the data is collected in their respective homes. The different environment refers to vehicle horn noises in some road facing rooms, internal background noises in some rooms like opening doors, silence in some rooms etc. All these recordings are used for training acoustic model. The Acoustic Model is trained on 8 speakers’ audio data. The vocabulary size of the recognizer is 10 words. HTK toolkit is used for building acoustic model and evaluating the recognition rate of the recognizer. The efficiency of the recognizer developed on recorded data, is shown at the end of the paper and possible directions for future research work are suggested

Synthesis and characterization of mixed ligand complexes of cobalt(II) and nickel( II) containing trans-[14]-diene and organic monobasic acids Synthesis and spectral studies of some aluminium(lll) complexes of N-protected amino acids

620-622A series of aluminium complexes of general formula AlCl3-n[OOCCH(R)(O)]n (where R= -CH3, -CH2C6H5 and n= 1,2,3) has been isolated by the interaction of aluminium trichloride with N-protected amino acids in 1:1, 1:2 and 1:3 molar ratios in dry diethyl ether solution. The tentative structures of these complexes have been suggested on the basis of elemental analyses, mol. wt. measurement and spectral studies. The freshly prepared complexes are monomers. 27Al NMR reveals the presence of four-, five- and six-coordinate aluminium centres in the complexes, [AlCI2(L)], [AlCl(L)2] and [Al(L)3], respectively

Evaluation of flaxseed formulation as a potential therapeutic agent in mitigation of dyslipidemia

Background: Cardiovascular diseases (CVDs) are an increasing health problem all over the world. The search for natural hypolipidemic agents that can be used besides the synthetic drugs is still in its experimental stage. Plant seeds, particularly flaxseed (Linum usitatissimum), which is a rich source of n-3 fatty acids, lignans and phenolic compounds, have also received increasing attention for their potential role in preventing lipid disorders. The present study was undertaken to evaluate the therapeutic potential of flaxseeds in dyslipidemia. Methods: The study included 50 dyslipidemic subjects selected by purposive random sampling and were divided into two groups, a control and an experimental group. Both the groups were prescribed similar dietary guidelines. Subjects in the experimental group received 30 g of roasted flaxseed powder for 3 months. Anthropometric parameters, blood pressure, and blood lipid profile were estimated before the study and after completion of the study. Results: Flaxseed supplementation resulted in a remarkable improvement in anthropometric measurements, blood pressure, and lipid profile in the experimental group. Body weight and body mass index (BMI) of the experimental group were significantly reduced (p < 0.01). A lowering of systolic and diastolic blood pressure (p < 0.05) was also recorded in the dyslipidemic subjects. Concomitantly, a highly significant reduction (p < 0.01) in total cholesterol, triglycerides, low density lipoprotein-cholesterol (LDL-C), and very low density lipoprotein-cholesterol (VLDL-C) levels, with simultaneous elevation (p < 0.01) in high density lipoprotein-cholesterol (HDL-C) levels was observed. Improvement in lipid levels resulted in reduction of atherogenic indices. Conclusions: The supplementation of roasted flaxseed powder for 3 months improved the BMI, blood pressure, and lipid profile of dyslipidemic subjects, thus exhibiting cardio protective effect

Adoption and Usage Intention of Consumers Towards Telemedicine Among People During Pandemic Times

OBJECTIVE: As COVID-19 engulfed the world, people are shifting to a new way of life with social distancing and self isolation, especially in developing countries. In such a scenario, online retailing has gone through a sea change with a new wave of increased demand and where the healthcare sector has also adjusted with the augmented transition from physical shops to e-commerce. The current study aims to assess the adoption and usage intention of consumers towards telemedicine among people during pandemic times. METHOD: The adoption of telemedicine by consumers depends upon some factors such as reliability, affordability, convenience, authenticity, offers and discount; which could enhance the intention to adopt and continual use by consumers. A modified version of ‘Technology Acceptance Model’ is incorporated in this study to validate the concept of adoption of telemedicine in cities of North India. RESULTS: The study has found the positive and significant relationship between the factors of adoption and the intention to adopt telemedicine. Also, the ‘Effect of COVID-19’ plays a moderating role between the different factors of adoption and the intention to adopt telemedicine. CONCLUSION: The adoption of telemedicine by people is significantly associated with different internal and external factors. The intention to adopt telemedicine is the construct that strongly influences the actual usage of telemedicine in developing countries. The scope of this study is restricted to the Northern region of India. A future study can be undertaken in relation to the global perspective of consumers

Effect of Pharmacovigilance on Herbal Medicines

Ayurvedic Medicines has major role in treatment of disease, this is originated from India and now it is accepted in other countries. Pharmacovigilance is related to detection, assessment, understanding and prevention of adverse drug reaction of drug and any other problems. There is increasing awareness in the world is needful to develop pharmacovigilance for herbal medicines. By applying standard pharmacovigilance techniques (WHO guidelines) presents additional challenges, related to the ways in which herbal medicines are regulated, used, named, and perceived. Correct reporting of suspected adverse drug reactions to herbal medicines is currently the main method of detection. But, there is under-reporting for herbal medicines, since users do not seek professional advice about their use of such products, or report adverse effects. An ADR is defined as a harmful or noxious reaction and unintended response to a marketed health product, which occurs at doses normally, used or tested for the treatment, diagnosis or prevention of a disease or the modification of an organic function. Plants have an important role in the development of modern medicines. More than 65-70% of modern medicines in the world marketed are directly or indirectly derived or developed from plant products. Herbal drug having adverse effect are Ginkgo biloba it causes Bleeding, Ephedra (Ma Huang) causes Hypertension, insomnia, arrhythmia, etc. With one and more clinical trials and other clinical research activities being conducted in India, there is an immense need to understand the importance of pharmacovigilance and how it impacts the lifecycle of the product. According to this situation, the DCGI should act quickly to improve pharmacovigilance so as to integrate Good Pharmacovigilance Practice into the processes and procedures to help ensure regulatory compliance and should enhance clinical trial safety and post marketing surveillance. It will be useful when healthcare professionals, regulatory authorities, pharmaceutical companies and the consumers are participated

A RETROSPECTIVE STUDY OF ANTENATAL TESTING IN WOMEN WITH REPRODUCTIVE AGE GROUP TRIBAL AREA

Objective: This retrospective study aimed to investigate the utilization and outcomes of antenatal testing among women of reproductive age in tribal areas. The study aimed to assess the extent to which antenatal testing services are utilized, identify potential barriers, and propose strategies to enhance healthcare delivery for this vulnerable population. Methods: Medical records of tribal women receiving antenatal care during a specific period were retrospectively examined. Data on antenatal tests, demographic characteristics, and geographical accessibility were collected. Statistical analysis, including chi-square tests and t-tests, was performed. Results: Age distribution analysis showed a majority of individuals in the 20-30 y age range. Hemoglobin levels were significantly higher in the "Muslim" group compared to the "Non-Muslim" group. No significant difference was found in total leukocyte count (TLC) and platelet levels between the two groups. Blood group distribution analysis revealed variations between the groups, with a borderline significant difference. Sickle cell status showed a significant difference, with a higher percentage of positive cases in the "NM" group. Conclusion: This study provides insights into the utilization and outcomes of antenatal testing in tribal areas. It highlights the need for targeted interventions to overcome barriers to access and improve antenatal care delivery in marginalized populations. The findings contribute to the existing literature, guiding policymakers and healthcare providers in developing equitable healthcare strategies for tribal women