Performance of three-photon PET imaging: Monte Carlo simulations

We have recently introduced the idea of making use of three-photon positron annihilations in positron emission tomography. In this paper the basic characteristics of the three-gamma imaging in PET are studied by means of Monte Carlo simulations and analytical computations. Two typical configurations of human and small animal scanners are considered. Three-photon imaging requires high energy resolution detectors. Parameters currently attainable by CdZnTe semiconductor detectors, the technology of choice for the future development of radiation imaging, are assumed. Spatial resolution is calculated as a function of detector energy resolution and size, position in the field of view, scanner size, and the energies of the three gamma annihilation photons. Possible ways to improve the spatial resolution obtained for nominal parameters: 1.5 cm and 3.2 mm FWHM for human and small animal scanners, respectively, are indicated. Counting rates of true and random three-photon events for typical human and small animal scanning configurations are assessed. A simple formula for minimum size of lesions detectable in the three-gamma based images is derived. Depending on the contrast and total number of registered counts, lesions of a few mm size for human and sub mm for small animal scanners can be detected

Do red deer stags (Cervus elaphus) use roar fundamental frequency (F0) to assess rivals?

It is well established that in humans, male voices are disproportionately lower pitched than female voices, and recent studies suggest that this dimorphism in fundamental frequency (F0) results from both intrasexual (male competition) and intersexual (female mate choice) selection for lower pitched voices in men. However, comparative investigations indicate that sexual dimorphism in F0 is not universal in terrestrial mammals. In the highly polygynous and sexually dimorphic Scottish red deer Cervus elaphus scoticus, more successful males give sexually-selected calls (roars) with higher minimum F0s, suggesting that high, rather than low F0s advertise quality in this subspecies. While playback experiments demonstrated that oestrous females prefer higher pitched roars, the potential role of roar F0 in male competition remains untested. Here we examined the response of rutting red deer stags to playbacks of re-synthesized male roars with different median F0s. Our results show that stags’ responses (latencies and durations of attention, vocal and approach responses) were not affected by the F0 of the roar. This suggests that intrasexual selection is unlikely to strongly influence the evolution of roar F0 in Scottish red deer stags, and illustrates how the F0 of terrestrial mammal vocal sexual signals may be subject to different selection pressures across species. Further investigations on species characterized by different F0 profiles are needed to provide a comparative background for evolutionary interpretations of sex differences in mammalian vocalizations

New imaging tools to measure nephron number in vivo: Opportunities for developmental nephrology

The mammalian kidney is a complex organ, requiring the concerted function of up to millions of nephrons. The number of nephrons is constant after nephrogenesis during development, and nephron loss over a life span can lead to susceptibility to acute or chronic kidney disease. New technologies are under development to count individual nephrons in the kidney in vivo. This review outlines these technologies and highlights their relevance to studies of human renal development and disease

Zero range potential for particles interacting via Coulomb potential: application to electron positron annihilation

The zero range potential is constructed for a system of two particles interacting via the Coulomb potential. The singular part of the asymptote of the wave function at the origin which is caused by the common effect of the zero range potential singularity and of the Coulomb potential is explicitly calculated by using the Lippmann-Schwinger type integral equation. The singular pseudo potential is constructed from the requirement that it enforces the solution to the Coulomb Schr\"odinger equation to possess the calculated asymptotic behavior at the origin. This pseudo potential is then used for constructing a model of the imaginary absorbing potential which allows to treat the annihilation process in positron electron collisions on the basis of the non relativistic Schr\"odinger equation. The functional form of the pseudo potential constructed in this paper is analogous to the well known Fermi-Breit-Huang pseudo potential. The generalization of the optical theorem on the case of the imaginary absorbing potential in presence of the Coulomb force is given in terms of the partial wave series

Can Age or Height Define Appropriate Thresholds for Transition to Adult Seat Belts? An Analysis of Observed Seat Belt Fit in Children Aged 7–12 Years

This study aimed to investigate associations between demographic, anthropometric and vehicle factors and the fit of adult seat belts in children aged 7–12 years in passenger vehicles. Seat belt fit was assessed by inspection of 7–12-year-old children in their own cars. Logistic regressions examined associations between anthropometric and vehicle factors on achieving good seat belt fit. There were 40 participants included in the analysis, with 16 (40%) having good overall belt fit. The odds of achieving good overall seat belt fit increased by 15% (OR 1.15, 95% CI 1.04–1.27) with every centimeter increase in height and increased by 5% with every one-month increase in age (OR 1.045, 95% CI 1.001–1.10). Controlling for vehicle factors, neither age or height was significantly associated with overall good belt fit, and the discriminatory power of models including these metrics to predict good belt fit was 73% (AUC 0.73, 95% CI 0.55–0.91) and 74% (AUC 0.74, 95% CI 0.58–0.91). The results suggest that taller and older children have a better chance of achieving a good seat belt fit. However, with variations in seat geometry between vehicles, no single simple metric clearly defines an appropriate transition to the adult seat belt

Stellar Populations in Compact Galaxy Groups: a Multi-Wavelength Study of HCGs 16, 22, and 42, their Star Clusters and Dwarf Galaxies

We present a multi-wavelength analysis of three compact galaxy groups, HCGs 16, 22, and 42, which describe a sequence in terms of gas richness, from space- (Swift, HST, Spitzer) and ground-based (LCO, CTIO) imaging and spectroscopy. We study various signs of past interactions including a faint, dusty tidal feature about HCG 16A, which we tentatively age-date at <1 Gyr. This represents the possible detection of a tidal feature at the end of its phase of optical observability. Our HST images also resolve what were thought to be double nuclei in HCG 16C and D into multiple, distinct sources, likely to be star clusters. Beyond our phenomenological treatment, we focus primarily on contrasting the stellar populations across these three groups. The star clusters show a remarkable intermediate-age population in HCG 22, and identify the time at which star formation was quenched in HCG 42. We also search for dwarf galaxies at accordant redshifts. The inclusion of 33 members and 27 'associates' (possible members) radically changes group dynamical masses, which in turn may affect previous evolutionary classifications. The extended membership paints a picture of relative isolation in HCGs 16 and 22, but shows HCG 42 to be part of a larger structure, following a dichotomy expected from recent studies. We conclude that (a) star cluster populations provide an excellent metric of evolutionary state, as they can age-date the past epochs of star formation; and (b) the extended dwarf galaxy population must be considered in assessing the dynamical state of a compact group.Comment: 29 pages, 13 figures. Accepted for publication in The Astrophysical Journa

The Spatial, Ionization, and Kinematic Conditions of the z=1.39 Damped Ly-alpha Absorber in Q0957+561 A,B

We examined the sizes of the absorption clouds in a z=1.3911 damped Ly-alpha absorber (DLA) in the double image lensed quasar Q0957+561 A,B (separation 135 pc at the absorber redshift). Using HIRES/Keck spectra, we studied the MgII 2796,2803 doublet, FeII multiplet, and MgI 2853 transition in absorption. We defined six "clouds" in the system of sightline A and seven clouds in the system of sightline B. An examination of the N(v) profiles, using the apparent optical depth method, reveals no clear physical connection between the clouds in A and those in B. The observed column density ratios of all clouds is log[N(MgI)/N(FeII)] ~ -2 across the full velocity range in both systems and also spatially (in both sightlines). This is a remarkable uniformity not seen in Lyman limit systems. The uniformity of the cloud properties suggests that the multiple clouds are not part of a "halo". Based upon photoionization modeling, we constrain the ionization parameters in the range -6.2 < log(U) < -5.1, where the range brackets known abundance ratio and dust depletion patterns. The inferred cloud properties are densities of 2 < n_H < 20 cm^-3, and line of sight sizes of 1 < D < 25 pc. The masses of the clouds in system A are 10 < M/M_sun < 1000 and in system B are 1 < M/M_sun < 60 for spherical clouds. For planar clouds, the upper limits are 400 M_sun and 160 M_sun for A and B, respectively. We favor a model of the absorber in which the DLA region itself is a single cloud in thiscomplex, which could be a parcel of gas in a galactic ISM. A spherical cloud of ~10 pc would be limited to one of the sightlines (A) and imply a covering factor less than 0.1 for the DLA complex. We infer that the DLA cloud properties are consistent with those of lower density, cold clouds in the Galactic interstellar medium.Comment: Accepted for publication in the Astrophysical Journal; final versio

Sub-seasonal forecasts of demand and wind power and solar power generation for 28 European countries

Electricity systems are becoming increasingly exposed to weather. The need for high-quality meteorological forecasts for managing risk across all timescales has therefore never been greater. This paper seeks to extend the uptake of meteorological data in the power systems modelling community to include probabilistic meteorological forecasts at sub-seasonal lead-times. Such forecasts are growing in skill and are receiving considerable attention in power system risk management and energy trading. Despite this interest, these forecasts are rarely evaluated in power system terms and technical barriers frequently prohibit use by non-meteorological specialists. This paper therefore presents data produced through a new EU climate services program Subseasonal-to-seasonal forecasting for Energy (S2S4E). The data corresponds to a suite of well-documented, easy-to-use, self-consistent daily- and nationally aggregated time-series for wind power, solar power and electricity demand across 28 European countries. The data is accessible from http://dx.doi.org/10.17864/1947.275, (Gonzalez et al., 2020). The data includes a set of daily ensemble reforecasts from two leading forecast systems spanning 20-years (ECMWF, an 11 member ensemble, with twice weekly starts for 1996-2016, totalling 21,210 forecasts) and 11 years (NCEP, a 12 member lagged-ensemble, constructed to match the start dates from the ECMWF forecast. from 1999-2010, totalling 4608 forecasts). The reforecasts containing multiple plausible realisations of daily-weather and power data for up to 6 weeks in the future. To the authors’ knowledge, this is the first time fully calibrated and post-processed daily power system forecast set has been published, and this is the primary purpose of this paper. A brief review of forecast skill in each of the individual primary power system properties and a composite property is presented, focusing on the winter season. The forecast systems contain additional skill over climatological expectation for weekly-average forecasts at extended lead-times, though this skill depends on the nature of the forecast metric considered. This highlights the need for greater collaboration between the energy- and meteorological research communities to develop applications, and it is hoped that publishing these data and tools will support this

Late glacial palaeoclimate investigations at King Arthur’s Cave and Sun Hole Cave.

King Arthur’s Cave (Wye Valley) and Sun Hole Cave (Cheddar Gorge) currently provide the earliest dates for a human presence in the British Isles after the Last Glacial Maximum. The earliest phase of activity at these sites has been dated to c. 15.2 to 14.6 thousand years cal. BP, which spans the onset of the Late Glacial Interstadial, a major global climate transition characterised by rapidly warming temperatures. Here we present stable isotope data from horse (Equus ferus) teeth found in the zooarchaeological assemblages at the sites. We also report two new radiocarbon dates on specimens from King Arthur’s Cave. The Equus tooth enamel provides a record of climatic conditions during the animals’ tooth formation. Evidence of human modification of the teeth (cut marks and fractures) chronologically tie these palaeoclimatic records to the earliest post-LGM archaeology at the two sites, thus informing on the climatic and environmental context under which human activity in these areas took place. Results indicate that people were present at the two sites during a period of climatic warming, with temperatures perhaps only marginally colder than present day conditions. However, suboptimal environmental conditions are suggested and may indicate changing vegetation dynamics within the local landscape