81 research outputs found
Repeated exposure to socioeconomic disadvantage and health selection as life course pathways to mid-life depressive and anxiety disorders
The biomedical examination was funded by
Medical Research Council [G0000934], awarded under the Health of
the Public initiative. Charlotte Clark is supported by an Engineering
and Physical Sciences Research Fellowship. Bryan Rodgers is supported
by Research Fellowships Nos 148948 and 366758 and by
Program Grant No. 179805 from the National Health and Medical
Research Council of Australia. Research at the Institute of Child
Health and Great Ormond Street Hospital for Children NHS Trust
benefits from R&D funding received from the NHS Executive
Combining functional weed ecology and crop stable isotope ratios to identify cultivation intensity: a comparison of cereal production regimes in Haute Provence, France and Asturias, Spain
This investigation combines two independent
methods of identifying crop growing conditions and husbandry
practicesâfunctional weed ecology and crop stable
carbon and nitrogen isotope analysisâin order to assess
their potential for inferring the intensity of past cereal
production systems using archaeobotanical assemblages.
Present-day organic cereal farming in Haute Provence,
France features crop varieties adapted to low-nutrient soils
managed through crop rotation, with little to no manuring.
Weed quadrat survey of 60 crop field transects in this region
revealed that floristic variation primarily reflects
geographical differences. Functional ecological weed data
clearly distinguish the Provence fields from those surveyed
in a previous study of intensively managed spelt wheat in
Asturias, north-western Spain: as expected, weed ecological
data reflect higher soil fertility and disturbance in
Asturias. Similarly, crop stable nitrogen isotope values
distinguish between intensive manuring in Asturias and
long-term cultivation with minimal manuring in Haute
Provence. The new model of cereal cultivation intensity
based on weed ecology and crop isotope values in Haute
Provence and Asturias was tested through application to
two other present-day regimes, successfully identifying a
high-intensity regime in the Sighisoara region, Romania,
and low-intensity production in Kastamonu, Turkey. Application
of this new model to Neolithic archaeobotanical
assemblages in central Europe suggests that early farming
tended to be intensive, and likely incorporated manuring,
but also exhibited considerable variation, providing a finer
grained understanding of cultivation intensity than previously
available
Introduction
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/67161/2/10.1177_0308275X9301300401.pd
Pharmacokinetic-Pharmacodynamic Modeling in Pediatric Drug Development, and the Importance of Standardized Scaling of Clearance.
Pharmacokinetic/pharmacodynamic (PKPD) modeling is important in the design and conduct of clinical pharmacology research in children. During drug development, PKPD modeling and simulation should underpin rational trial design and facilitate extrapolation to investigate efficacy and safety. The application of PKPD modeling to optimize dosing recommendations and therapeutic drug monitoring is also increasing, and PKPD model-based dose individualization will become a core feature of personalized medicine. Following extensive progress on pediatric PK modeling, a greater emphasis now needs to be placed on PD modeling to understand age-related changes in drug effects. This paper discusses the principles of PKPD modeling in the context of pediatric drug development, summarizing how important PK parameters, such as clearance (CL), are scaled with size and age, and highlights a standardized method for CL scaling in children. One standard scaling method would facilitate comparison of PK parameters across multiple studies, thus increasing the utility of existing PK models and facilitating optimal design of new studies
The James Webb Space Telescope Mission
Twenty-six years ago a small committee report, building on earlier studies,
expounded a compelling and poetic vision for the future of astronomy, calling
for an infrared-optimized space telescope with an aperture of at least .
With the support of their governments in the US, Europe, and Canada, 20,000
people realized that vision as the James Webb Space Telescope. A
generation of astronomers will celebrate their accomplishments for the life of
the mission, potentially as long as 20 years, and beyond. This report and the
scientific discoveries that follow are extended thank-you notes to the 20,000
team members. The telescope is working perfectly, with much better image
quality than expected. In this and accompanying papers, we give a brief
history, describe the observatory, outline its objectives and current observing
program, and discuss the inventions and people who made it possible. We cite
detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space
Telescope Overview, 29 pages, 4 figure
The Helicobacter pylori Genome Project : insights into H. pylori population structure from analysis of a worldwide collection of complete genomes
Helicobacter pylori, a dominant member of the gastric microbiota, shares co-evolutionary history with humans. This has led to the development of genetically distinct H. pylori subpopulations associated with the geographic origin of the host and with differential gastric disease risk. Here, we provide insights into H. pylori population structure as a part of the Helicobacter pylori Genome Project (HpGP), a multi-disciplinary initiative aimed at elucidating H. pylori pathogenesis and identifying new therapeutic targets. We collected 1011 well-characterized clinical strains from 50 countries and generated high-quality genome sequences. We analysed core genome diversity and population structure of the HpGP dataset and 255 worldwide reference genomes to outline the ancestral contribution to Eurasian, African, and American populations. We found evidence of substantial contribution of population hpNorthAsia and subpopulation hspUral in Northern European H. pylori. The genomes of H. pylori isolated from northern and southern Indigenous Americans differed in that bacteria isolated in northern Indigenous communities were more similar to North Asian H. pylori while the southern had higher relatedness to hpEastAsia. Notably, we also found a highly clonal yet geographically dispersed North American subpopulation, which is negative for the cag pathogenicity island, and present in 7% of sequenced US genomes. We expect the HpGP dataset and the corresponding strains to become a major asset for H. pylori genomics
Early Analysis of the Economics of Family Structure: Charlotte Perkins Gilman's Women and Economicsf:0034â6764/94/0601â86/ef:
âWhy Don't I Know About These Women?â: The Integration of Early Women Sociologists in Classical Theory Courses
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