Influence of a small fraction of individuals with enhanced mutations on a population genetic pool

Computer simulations of the Penna ageing model suggest that already a small fraction of births with enhanced number of new mutations can negatively influence the whole population.Comment: 10 pages including 6 figures; draf

The Potential to Address Disease Vectors in Favelas in Brazil Using Sustainable Drainage Systems:Zika, Drainage and Greywater Management

Residents of informal settlements, the world over, suffer consequences due to the lack of drainage and greywater management, impacting human and environmental health. In Brazil, the presence of the Aedes aegypti mosquito in urban areas promotes infections of the Zika virus as well as companion viruses, such as dengue, chikungunya and yellow fever. By using observation and interviews with the community, this paper shows how a simple sustainable drainage system approach could prevent the accumulation of on-street standing water, and thus reduce opportunities for the mosquito to breed and reduce infection rates. During the interview phase, it became apparent that underlying misinformation and misunderstandings prevail related to existing environmental conditions in favelas and the role of the mosquito in infecting residents. This inhibits recommendations made by professionals to reduce breeding opportunities for the disease vector. Whilst unrest is an issue in favelas, it is not the only issue preventing the human right to reliable, safe sanitation, including drainage. In “pacified” favelas which may be considered safe(r), the infrastructure is still poor and is not connected to the city-wide sanitation/treatment networks

Stress begins in kindergarten: A look at behavior during standardized testing

Kindergarten children’s behavior before, during, and after standardized achievement testing was explored through a qualitative study in two classrooms (n = 36). Simultaneously quantitative data were collected in one of the classrooms (n = 21) before and during the testing. Data were collected through observations in the classrooms, interviews with children and teachers, and audio and video taping of the children. For the quantitative component of the study, frequencies of stress behaviors were observed using a scan sampling method. Qualitative findings indicated an increase in behaviors reported to be stress related during the testing and a decrease in those behaviors following the testing. Copying and calling out answers during the testing were also observed frequently. Children also marked incorrect answers, but when interviewed after the test, could respond correctly. Quantitative results supported the qualitative with a statistically significant increase in the proportion of stress behaviors observed during testing (M = .77; n = 21) when compared with the proportion during normal classroom activities (M = .25; t[20] = -13.37, p \u3c.001). © 1992 Taylor & Francis Group, LLC

Kaleidoscopic associations between life outside home and the technological environment that shape occupational injustice as revealed through cross-sectional statistical modelling

BACKGROUND: Everyday life outside home and accessing a variety of places are central to occupation. Technology is ever more taken for granted, even outside home, and for some may culminate in occupational injustice. This study aims to explore the association between everyday technologies (ET), particularly out of home, and the number of places older adults with and without dementia go to, in rural and urban environments. METHOD: The Everyday Technology Use Questionnaire, and Participation in Activities and Places Outside Home Questionnaire, were administered with 128 people in England. Six logistic regression models explored the association between ET and the number of places people went to, with other demographic factors (i.e., rurality, diagnosis, deprivation). RESULTS: The amount of out of home technologies a person perceived relevant and relative levels of neighbourhood deprivation were most persistently associated with the number of places people went to. Associations with ability to use technology, diagnosis, and education were more tentative. In no model was rurality significant. All models explained a low proportion of variance and lacked sensitivity to predict the outcome. CONCLUSION: For a minority of people, perceptions of the technological environment are associated with other personal and environmental dimensions. Viewed kaleidoscopically, these associations assemble to generate an impermanent, fragmented view of occupational injustice that may jeopardise opportunities outside home. However, there will be other influential factors not identified in this study. Greater attention to the intersections between specific environmental dimensions may deepen understanding of how modifications can be made to deliver occupational justice

Genome-wide linkage scan for loci influencing plasma triglyceride levels

We conducted a genome-wide linkage scan to detect loci that influence the levels of fasting triglycerides in plasma. Fasting triglyceride levels were available at 4 time points (visits), 2 pre- and 2 post-fenofibrate intervention. Multipoint identity-by-descent (MIBD) matrices were derived from genotypes using IBDLD. Variance-component linkage analyses were then conducted using SOLAR (Sequential Oligogenic Linkage Analysis Routines). We found evidence of linkage (logarithm of odds [LOD] ≥3) at 5 chromosomal regions with triglyceride levels in plasma. The highest LOD scores were observed for linkage to the estimated genetic value (additive genetic component) of the log-normalized triglyceride levels in plasma. Our results suggest that a chromosome 10 locus at 37 cM (LODpre = 3.01, LODpost = 3.72) influences fasting triglyceride levels in plasma regardless of the fenofibrate intervention, and that loci in chromosomes 1 at 170 cM and 4 at 24 cM ceases to affect the triglyceride levels when fenofibrate is present, while the regions in chromosomes 6 at 136 to 162 cM and 11 at 39 to 40 cM appear to influence triglyceride levels in response to fenofibrate

Social Participation in Relation to Technology Use and Social Deprivation: A Mixed Methods Study Among Older People with and without Dementia

Social participation is a modifiable determinant for health and wellbeing among older people; however, social participation is increasingly dependent on technology use. This study investigated social participation in relation to Everyday Technology use and social deprivation of the living environment, among older people with and without dementia in the United Kingdom. Sixty-four people with dementia and sixty-four people without dementia were interviewed using standardized questionnaires: The Participation in ACTivities and Places OUTside Home Questionnaire and Everyday Technology Use Questionnaire. A mixed methods approach integrated statistical analyses and content analysis of free-text responses, through data visualizations. Small, statistically significant associations were found between social participation and Everyday Technology use outside home, for participants with dementia (Rs = 0.247; p = 0.049) and without dementia (Rs = 0.343; p = 0.006). A small, statistically significant association was identified between social participation and social deprivation in the living environment, among only participants with dementia (Rs = 0.267, p = 0.033). The content analysis and graphical joint display revealed motivators, considerations that require extra attention, and strategies for managing social participation. The results underline how Everyday Technology use can be assistive to social participation but also the need to consider social deprivation of the living environment, especially among people with dementia

Impact of the developmental appropriateness of teacher guidance strategies on kindergarten children’s interpersonal relations

This initial study explored the social behaviors of kindergarten children in two classrooms (one developmentally appropriate, one developmentally inappropriate) where the teacher used either positive or negative guidance strategies. Six pairs of kindergartners-three dyads (boy-boy, girl-girl, boy-girl) from a classroom in which the teacher used positive guidance strategies and three from a classroom where the teacher used negative guidance strategies-were observed while playing in a researcher-designed play center. Observations over a three-month period revealed an increase in positive social behaviors among children from the positive guidance classroom and a decrease in positive social behaviors among children from the negative guidance classroom. Implications are discussed. © 2007 by the Association for Childhood Education International

The role of mutation rate variation and genetic diversity in the architecture of human disease

Background We have investigated the role that the mutation rate and the structure of genetic variation at a locus play in determining whether a gene is involved in disease. We predict that the mutation rate and its genetic diversity should be higher in genes associated with disease, unless all genes that could cause disease have already been identified. Results Consistent with our predictions we find that genes associated with Mendelian and complex disease are substantially longer than non-disease genes. However, we find that both Mendelian and complex disease genes are found in regions of the genome with relatively low mutation rates, as inferred from intron divergence between humans and chimpanzees, and they are predicted to have similar rates of non-synonymous mutation as other genes. Finally, we find that disease genes are in regions of significantly elevated genetic diversity, even when variation in the rate of mutation is controlled for. The effect is small nevertheless. Conclusions Our results suggest that gene length contributes to whether a gene is associated with disease. However, the mutation rate and the genetic architecture of the locus appear to play only a minor role in determining whether a gene is associated with disease