Can a combination of the conformal thin-sandwich and puncture methods yield binary black hole solutions in quasi-equilibrium?

We consider combining two important methods for constructing quasi-equilibrium initial data for binary black holes: the conformal thin-sandwich formalism and the puncture method. The former seeks to enforce stationarity in the conformal three-metric and the latter attempts to avoid internal boundaries, like minimal surfaces or apparent horizons. We show that these two methods make partially conflicting requirements on the boundary conditions that determine the time slices. In particular, it does not seem possible to construct slices that are quasi-stationary and avoid physical singularities and simultaneously are connected by an everywhere positive lapse function, a condition which must obtain if internal boundaries are to be avoided. Some relaxation of these conflicting requirements may yield a soluble system, but some of the advantages that were sought in combining these approaches will be lost.Comment: 8 pages, LaTeX2e, 2 postscript figure

Empirical ugri-UBVRc Transformations for Galaxies

We present empirical color transformations between Sloan Digital Sky Survey ugri and Johnson-Cousins UBVRc photometry for nearby galaxies (D < 11 Mpc). We use the Local Volume Legacy (LVL) galaxy sample where there are 90 galaxies with overlapping observational coverage for these two filter sets. The LVL galaxy sample consists of normal, non-starbursting galaxies. We also examine how well the LVL galaxy colors are described by previous transformations derived from standard calibration stars and model-based galaxy templates. We find significant galaxy color scatter around most of the previous transformation relationships. In addition, the previous transformations show systematic offsets between transformed and observed galaxy colors which are visible in observed color-color trends. The LVL-based $galaxy$ transformations show no systematic color offsets and reproduce the observed color-color galaxy trends.Comment: Accepted for publication in MNRAS (9 pages, 6 figures, 4 tables

Spitzer Local Volume Legacy (LVL) SEDs and Physical Properties

We present the panchromatic spectral energy distributions (SEDs) of the Local Volume Legacy (LVL) survey which consists of 258 nearby galaxies ($D<$11 Mpc). The wavelength coverage spans the ultraviolet to the infrared (1500 $\textrm{\AA}$ to 24 $\mu$m) which is utilized to derive global physical properties (i.e., star formation rate, stellar mass, internal extinction due to dust.). With these data, we find color-color relationships and correlated trends between observed and physical properties (i.e., optical magnitudes and dust properties, optical color and specific star formation rate, and ultraviolet-infrared color and metallicity). The SEDs are binned by different galaxy properties to reveal how each property affects the observed shape of these SEDs. In addition, due to the volume-limited nature of LVL, we utilize the dwarf-dominated galaxy sample to test star formation relationships established with higher-mass galaxy samples. We find good agreement with the star-forming "main-sequence" relationship, but find a systematic deviation in the infrared "main-sequence" at low luminosities. This deviation is attributed to suppressed polycyclic aromatic hydrocarbon (PAH) formation in low metallicity environments and/or the destruction of PAHs in more intense radiation fields occurring near a suggested threshold in sSFR at a value of log($sSFR$) $\sim$ $-$10.2.Comment: Accepted for publication in MNRAS (15 pages, 14 figures, 1 table

The Spitzer Local Volume Legacy (LVL) Global Optical Photometry

We present the global optical photometry of 246 galaxies in the Local Volume Legacy (LVL) survey. The full volume-limited sample consists of 258 nearby (D < 11 Mpc) galaxies whose absolute B-band magnitude span a range of -9.6 < M_B < -20.7 mag. A composite optical (UBVR) data set is constructed from observed UBVR and SDSS ugriz imaging, where the ugriz magnitudes are transformed into UBVR. We present photometry within three galaxy apertures defined at UV, optical, and IR wavelengths. Flux comparisons between these apertures reveal that the traditional optical R25 galaxy apertures do not fully encompass extended sources. Using the larger IR apertures we find color-color relationships where later-type spiral and irregular galaxies tend to be bluer than earlier-type galaxies. These data provide the missing optical emission from which future LVL studies can construct the full panchromatic (UV-optical-IR) spectral energy distributions.Comment: Accepted for publication in MNRAS (9 pages, 5 figures, 5 tables

Physical and Mental Health of Transgender Older Adults: An At-Risk and Underserved Population

Purpose: This study is one of the first to examine the physical and mental health of transgender older adults and to identify modifiable factors that account for health risks in this underserved population. Design and Methods: Utilizing data from a cross-sectional survey of lesbian, gay, bisexual, and transgender older adults aged 50 and older (N = 2,560), we assessed direct and indirect effects of gender identity on 4 health outcomes (physical health, disability, depressive symptomatology, and perceived stress) based on a resilience conceptual framework. Results: Transgender older adults were at significantly higher risk of poor physical health, disability, depressive symptomatology, and perceived stress compared with nontransgender participants. We found significant indirect effects of gender identity on the health outcomes via fear of accessing health services, lack of physical activity, internalized stigma, victimization, and lack of social support; other mediators included obesity for physical health and disability, identity concealment for perceived stress, and community belonging for depressive symptomatology and perceived stress. Further analyses revealed that risk factors (victimization and stigma) explained the highest proportion of the total effect of gender identity on health outcomes. Implications: The study identifies important modifiable factors (stigma, victimization, health-related behaviors, and social support) associated with health among transgender older adults. Reducing stigma and victimization and including gender identity in nondiscrimination and hate crime statutes are important steps to reduce health risks. Attention to bolstering individual and community-level social support must be considered when developing tailored interventions to address transgender older adults’ distinct health and aging needs

Sleep Health, Individual Characteristics, Lifestyle Factors, and Marathon Completion Time in Marathon Runners: A Retrospective Investigation of the 2016 London Marathon

Despite sleep health being critically important for athlete performance and well-being, sleep health in marathoners is understudied. This foundational study explored relations between sleep health, individual characteristics, lifestyle factors, and marathon completion time. Data were obtained from the 2016 London Marathon participants. Participants completed the Athlete Sleep Screening Questionnaire (ASSQ) along with a brief survey capturing individual characteristics and lifestyle factors. Sleep health focused on the ASSQ sleep difficulty score (SDS) and its components. Linear regression computed relations among sleep, individual, lifestyle, and marathon variables. The analytic sample (N = 943) was mostly male (64.5%) and young adults (66.5%). A total of 23.5% of the sample reported sleep difficulties (SDS ≥ 8) at a severity warranting follow-up with a trained sleep provider. Middle-aged adults generally reported significantly worse sleep health characteristics, relative to young adults, except young adults reported significantly longer sleep onset latency (SOL). Sleep tracker users reported worse sleep satisfaction. Pre-bedtime electronic device use was associated with longer SOL and longer marathon completion time, while increasing SOL was also associated with longer marathon completion. Our results suggest a deleterious influence of pre-bedtime electronic device use and sleep tracker use on sleep health in marathoners. Orthosomnia may be a relevant factor in the relationship between sleep tracking and sleep health for marathoners

Early reconstitution of effector memory CD4+ CMV-specific T cells protects against CMV reactivation following allogeneic SCT.

Reactivation of CMV is a common complication following allogeneic haematopoietic SCT and is associated with significant morbidity and mortality. The relative importance of the CD4+ and CD8+ components of the CMV-specific immune response in protection from reactivation is unclear. The CMV-specific CD4+ and CD8+ immune response was measured at serial time points in 32 patients following allogeneic HSCT. Intracellular cytokine staining following CMV lysate stimulation and HLA-peptide tetramers were used to determine CMV-specific CD4+ and CD8+ responses, respectively. A deficient CMV-specific CD4+ T-cell immune response within the first 30-50 days post transplant was associated with high risk of viral reactivation. Patients with combined impairment of the CD4+ and CD8+ immune response within the first 100 days were susceptible to late viral reactivation. The frequency of CMV-specific CD4+ T cells correlated with CMV-specific CD8+ T cells, comprising 10% of the whole T-cell repertoire. Early CMV-specific CD4+ T-cell reconstitution was dominated by effector memory cells with normal levels of IL-2 resuming 6 months following transplantation. In summary, both CD4 and CD8 CMV-specific immune reconstitution is required for protection from recurrent activation. Measurement of the magnitude of the CMV-specific CD4+ immune response is useful in managing viral reactivation following HSCT

Screening for Major Depressive Disorder in Children and Adolescents: A Systematic Review for the U.S. Preventive Services Task Force

BACKGROUND: Major depressive disorder (MDD) is common among children and adolescents and is associated with functional impairment and suicide. PURPOSE: To update the 2009 U.S. Preventive Services Task Force (USPSTF) systematic review on screening for and treatment of MDD in children and adolescents in primary care settings. DATA SOURCES: Several electronic searches (May 2007 to February 2015) and searches of reference lists of published literature. STUDY SELECTION: Trials and recent systematic reviews of treatment, test-retest studies of screening, and trials and large cohort studies for harms. DATA EXTRACTION: Data were abstracted by 1 investigator and checked by another; 2 investigators independently assessed study quality. DATA SYNTHESIS: Limited evidence from 5 studies showed that such tools as the Beck Depression Inventory and Patient Health Questionnaire for Adolescents had reasonable accuracy for identifying MDD among adolescents in primary care settings. Six trials evaluated treatment. Several individual fair- and good-quality studies of fluoxetine, combined fluoxetine and cognitive behavioral therapy, escitalopram, and collaborative care demonstrated benefits of treatment among adolescents, with no associated harms. LIMITATION: The review included only English-language studies, narrow inclusion criteria focused only on MDD, high thresholds for quality, potential publication bias, limited data on harms, and sparse evidence on long-term outcomes of screening and treatment among children younger than 12 years. CONCLUSION: No evidence was found of a direct link between screening children and adolescents for MDD in primary care or similar settings and depression or other health-related outcomes. Evidence showed that some screening tools are accurate and some treatments are beneficial among adolescents (but not younger children), with no evidence of associated harms. PRIMARY FUNDING SOURCE: Agency for Healthcare Research and Quality