The systemic environment: at the interface of aging and adult neurogenesis.

Aging results in impaired neurogenesis in the two neurogenic niches of the adult mammalian brain, the dentate gyrus of the hippocampus and the subventricular zone of the lateral ventricle. While significant work has characterized intrinsic cellular changes that contribute to this decline, it is increasingly apparent that the systemic environment also represents a critical driver of brain aging. Indeed, emerging studies utilizing the model of heterochronic parabiosis have revealed that immune-related molecular and cellular changes in the aging systemic environment negatively regulate adult neurogenesis. Interestingly, these studies have also demonstrated that age-related decline in neurogenesis can be ameliorated by exposure to the young systemic environment. While this burgeoning field of research is increasingly garnering interest, as yet, the precise mechanisms driving either the pro-aging effects of aged blood or the rejuvenating effects of young blood remain to be thoroughly defined. Here, we review how age-related changes in blood, blood-borne factors, and peripheral immune cells contribute to the age-related decline in adult neurogenesis in the mammalian brain, and posit both direct neural stem cell and indirect neurogenic niche-mediated mechanisms

X-ray Dust Scattering at Small Angles: The Complete Halo around GX13+1

The exquisite angular resolution available with Chandra should allow precision measurements of faint diffuse emission surrounding bright sources, such as the X-ray scattering halos created by interstellar dust. However, the ACIS CCDs suffer from pileup when observing bright sources, and this creates difficulties when trying to extract the scattered halo near the source. The initial study of the X-ray halo around GX13+1 using only the ACIS-I detector done by Smith, Edgar & Shafer (2002) suffered from a lack of sensitivity within 50'' of the source, limiting what conclusions could be drawn. To address this problem, observations of GX13+1 were obtained with the Chandra HRC-I and simultaneously with the RXTE PCA. Combined with the existing ACIS-I data, this allowed measurements of the X-ray halo between 2-1000''. After considering a range of dust models, each assumed to be smoothly distributed with or without a dense cloud along the line of sight, the results show that there is no evidence in this data for a dense cloud near the source, as suggested by Xiang et al. (2005). Finally, although no model leads to formally acceptable results, the Weingartner & Draine (2001) and nearly all of the composite grain models from Zubko, Dwek & Arendt (2004) give poor fits.Comment: 8 pages, 6 figures, accepted for publication in Ap

Performance and loads data from an outdoor hover test of a Lynx tail rotor

A Lynx tail rotor was tested in hover at the Outdoor Aerodynamic Research Facility at NASA Ames Research Center. The test objectives were to measure the isolated rotor performance to provide a baseline for subsequent testing, and to operate the rotor throughout the speed and collective envelope before testing in the NFAC 40- by 80-Foot Wind Tunnel. Rotor forces and blade bending moments were measured at ambient wind conditions from zero to 6.23 m/sec. The test envelope was limited to rotor speeds of 1550 to 1850 rpm and minus 13 deg to plus 20 deg of blade collective pitch. The isolated rotor performance and blade loads data are presented

Magnetic field waves at Uranus

The proposed research efforts funded by the UDAP grant to the BRI involve the study of magnetic field waves associated with the Uranian bow shock. This is a collaborative venture bringing together investigators at the BRI, Southwest Research Institute (SwRI), and Goddard Space Flight Center (GSFC). In addition, other collaborations have been formed with investigators granted UDAP funds for similar studies and with investigators affiliated with other Voyager experiments. These investigations and the corresponding collaborations are included in the report. The proposed effort as originally conceived included an examination of waves downstream from the shock within the magnetosheath. However, the observations of unexpected complexity and diversity within the upstream region have necessitated that we confine our efforts to those observations recorded upstream of the bow shock on the inbound and outbound legs of the encounter by the Voyager 2 spacecraft

Phase I Archaeological Survey of a 10-acre Habitat for Humanity Tract in Laredo, Webb County, Texas

On December 7, 2004, the Center for Archaeological Research (CAR) conducted a Phase I intensive pedestrian archaeological survey of a 10-acre portion of Tract 4 in the Las Blancas Subdivision located near Laredo in Webb County, Texas, for Habitat for Humanity of Laredo. The proposed development consists of the construction of low-income housing within this parcel. Twenty shovel tests were excavated along 20-meter transects and in areas considered to have high or moderate probability of buried cultural materials. In addition, two backhoe trenches were excavated in alluvial deposits along the eastern margin of the project area overlooking Blancas Creek. The survey resulted in the identification of one archaeological site, 41WB633, an apparent lithic procurement locality. Site 41WB633 covers approximately 6.4 acres and extends beyond the survey area. The core area with the highest density of surface materials measures approximately 65 x 45 meters and contains early reduction stage bifaces, cores, and lithic debitage scattered across the surface. Only one of the 20 shovel tests (ST 10) placed within the site recovered subsurface materials buried in Levels 1–3, at 0–30 cm below surface. Neither of the two backhoe trenches excavated within the boundaries of the site yielded subsurface materials. The geoarchaeological investigations indicate that the prehistoric lithic artifacts show no evidence of alluvial or colluvial abrasion and only minimal patination was observed on a few pieces. This suggests that they are not the product of significant high-energy redeposition. Although the surface gravels may have been formed by colluvial or eolian processes, the fresh, undamaged edges of the lithics indicate that events concentrating the gravels probably occurred prior to deposition of the archaeological materials. Given the lack of isolable archaeological deposits at 41WB633, the overall low density of cultural materials, and the absence of a comprehensive research context within which such lithic procurement sites can be interpreted, CAR recommends that the site does not merit designation as a State Archeological Landmark and does not warrant nomination to the National Register of Historic Places. Therefore, it is CAR’s recommendation that the construction work associated with the development of this 10-acre portion of the Las Blancas Subdivision proceed as planned. Because the property was privately owned at the time of the fieldwork, and no state funds will be employed in the construction effort, no Texas Antiquities Committee permit was necessary for this undertaking. The artifacts collected during the survey will be curated at CAR unless otherwise requested by the landowner. All project-associated documents are curated at the Center for Archaeological Research at The University of Texas at San Antonio

High-Resolution Mid-Infrared Morphology of Cygnus A

We present subarcsecond resolution mid-infrared images at 10.8 and 18.2 microns of Cygnus A. These images were obtained with the University of Florida mid-IR camera/spectrometer OSCIR at the Keck II 10-m telescope. Our data show extended mid-IR emission primarily to the east of the nucleus with a possible western extension detected after image deconvolution. This extended emission is closely aligned with the bi-conical structure observed at optical and near-IR wavelengths by the HST. This emission is consistent with dust heated from the central engine of Cygnus A. We also marginally detect large-scale low level emission extending > 1.5 kpc from the nucleus which may be caused by in-situ star formation, line emission, and/or PAH contamination within the bandpass of our wide N-band filter.Comment: 20 pages, 8 figures, accepted for publication in the Astrophysical Journa

Multimodal Imaging Evidence for Axonal and Myelin Deterioration in Amnestic Mild Cognitive Impairment

White matter (WM) microstructural declines have been demonstrated in Alzheimer\u27s disease and amnestic mild cognitive impairment (aMCI). However, the pattern of WM microstructural changes in aMCI after controlling for WM atrophy is unknown. Here, we address this issue through joint consideration of aMCI alterations in fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity, as well as macrostructural volume in WM and gray matter compartments. Participants were 18 individuals with aMCI and 24 healthy seniors. Voxelwise analyses of diffusion tensor imaging data was carried out using tract-based spatial statistics (TBSS) and voxelwise analyses of high-resolution structural data was conducted using voxel based morphometry. After controlling for WM atrophy, the main pattern of TBSS findings indicated reduced fractional anisotropy with only small alterations in mean diffusivity/radial diffusivity/axial diffusivity. These WM microstructural declines bordered and/or were connected to gray matter structures showing volumetric declines. However, none of the potential relationships between WM integrity and volume in connected gray matter structures was significant, and adding fractional anisotropy information improved the classificatory accuracy of aMCI compared to the use of hippocampal atrophy alone. These results suggest that WM microstructural declines provide unique information not captured by atrophy measures that may aid the magnetic resonance imaging contribution to aMCI detection

Non-equilibrium dynamics and floral trait interactions shape extant angiosperm diversity.

Why are some traits and trait combinations exceptionally common across the tree of life, whereas others are vanishingly rare? The distribution of trait diversity across a clade at any time depends on the ancestral state of the clade, the rate at which new phenotypes evolve, the differences in speciation and extinction rates across lineages, and whether an equilibrium has been reached. Here we examine the role of transition rates, differential diversification (speciation minus extinction) and non-equilibrium dynamics on the evolutionary history of angiosperms, a clade well known for the abundance of some trait combinations and the rarity of others. Our analysis reveals that three character states (corolla present, bilateral symmetry, reduced stamen number) act synergistically as a key innovation, doubling diversification rates for lineages in which this combination occurs. However, this combination is currently less common than predicted at equilibrium because the individual characters evolve infrequently. Simulations suggest that angiosperms will remain far from the equilibrium frequencies of character states well into the future. Such non-equilibrium dynamics may be common when major innovations evolve rarely, allowing lineages with ancestral forms to persist, and even outnumber those with diversification-enhancing states, for tens of millions of years