Trimers, molecules and polarons in imbalanced atomic Fermi gases

We consider the ground state of a single "spin-down" impurity atom interacting attractively with a "spin-up" atomic Fermi gas. By constructing variational wave functions for polarons, molecules and trimers, we perform a detailed study of the transitions between each of these dressed bound states as a function of mass ratio $r=m_\uparrow/m_\downarrow$ and interaction strength. We find that the presence of a Fermi sea enhances the stability of the $p$-wave trimer, which can be viewed as a Fulde-Ferrell-Larkin-Ovchinnikov (FFLO) molecule that has bound an additional majority atom. For sufficiently large $r$, we find that the transitions lie outside the region of phase separation in imbalanced Fermi gases and should thus be observable in experiment, unlike the well-studied equal-mass case.Comment: 5 pages, 2 figure

Quantum Flutter: Signatures and Robustness

We investigate the motion of an impurity particle injected with finite velocity into an interacting one-dimensional quantum gas. Using large-scale numerical simulations based on matrix product states, we observe and quantitatively analyze long-lived oscillations of the impurity momentum around a nonzero saturation value, called quantum flutter. We show that the quantum flutter frequency is equal to the energy difference between two branches of collective excitations of the model. We propose an explanation of the finite saturation momentum of the impurity based on the properties of the edge of the excitation spectrum. Our results indicate that quantum flutter exists away from integrability and provide parameter regions in which it could be observed in experiments with ultracold atoms using currently available technology.Physic

Quantum flutter of supersonic particles in one-dimensional quantum liquids

The non-equilibrium dynamics of strongly correlated many-body systems exhibits some of the most puzzling phenomena and challenging problems in condensed matter physics. Here we report on essentially exact results on the time evolution of an impurity injected at a finite velocity into a one-dimensional quantum liquid. We provide the first quantitative study of the formation of the correlation hole around a particle in a strongly coupled many-body quantum system, and find that the resulting correlated state does not come to a complete stop but reaches a steady state which propagates at a finite velocity. We also uncover a novel physical phenomenon when the impurity is injected at supersonic velocities: the correlation hole undergoes long-lived coherent oscillations around the impurity, an effect we call quantum flutter. We provide a detailed understanding and an intuitive physical picture of these intriguing discoveries, and propose an experimental setup where this physics can be realized and probed directly.Comment: 13 pages, 9 figure

A SARS-CoV-2 protein interaction map reveals targets for drug repurposing

The novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 2.3 million people, killed over 160,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven clinical efficacy, nor are there vaccines for its prevention, and these efforts are hampered by limited knowledge of the molecular details of SARS-CoV-2 infection. To address this, we cloned, tagged and expressed 26 of the 29 SARS-CoV-2 proteins in human cells and identified the human proteins physically associated with each using affinity-purification mass spectrometry (AP-MS), identifying 332 high-confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 compounds (29 FDA-approved drugs, 12 drugs in clinical trials, and 28 preclinical compounds). Screening a subset of these in multiple viral assays identified two sets of pharmacological agents that displayed antiviral activity: inhibitors of mRNA translation and predicted regulators of the Sigma1 and Sigma2 receptors. Further studies of these host factor targeting agents, including their combination with drugs that directly target viral enzymes, could lead to a therapeutic regimen to treat COVID-19

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurposing.

An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, and caused worldwide social and economic disruption1,2. There are currently no antiviral drugs with proven efficacy nor are there vaccines for its prevention. Unfortunately, the scientific community has little knowledge of the molecular details of SARS-CoV-2 infection. To illuminate this, we cloned, tagged and expressed 26 of the 29 viral proteins in human cells and identified the human proteins physically associated with each using affinity- purification mass spectrometry (AP-MS), which identified 332 high confidence SARS-CoV-2-human protein-protein interactions (PPIs). Among these, we identify 66 druggable human proteins or host factors targeted by 69 existing FDA-approved drugs, drugs in clinical trials and/or preclinical compounds, that we are currently evaluating for efficacy in live SARS-CoV-2 infection assays. The identification of host dependency factors mediating virus infection may provide key insights into effective molecular targets for developing broadly acting antiviral therapeutics against SARS-CoV-2 and other deadly coronavirus strains

Laboratories for global space-time: science-fictionality and the World’s Fairs, 1851-1939

This article examines the world’s fair movement between The Great Exhibition of 1851 and The New York World’s Fair of 1939, suggesting that these sites are science-fictional spaces that expose their mass audiences to forms of space-time compression that enable early figurations of globalization. Fair sites embody specific forms of economic transfer and exchange that anticipate dreams of the borderless flows of capital in some current versions of globalization theory. This “sfnal” condition of the world’s-fair site is not just in the futuristic displays of techno-scientific “progress,” which became an insistent form of spectacle in the world’s fair, but also in the spatialization of developmental histories, reading conceptions of modernity remorselessly through hierarchies of racial “progress” or spectacles of anachronistic “arrest” or degenerative “decline.” Long before the famous Futurama of 1939 New York, world’s fairs were one of the first spaces in which large populations experienced deliberate and sustained disadjustment in time within a bounded zone, an early sense of immersion in the “science-fictional.