1,363 research outputs found
Do OB Runaway Stars Have Pulsar Companions?
We have conducted a VLA search for radio pulsars at the positions of 44
nearby OB runaway stars. The observations involved both searching images for
point sources of continuum emission and a time series analysis. Our mean flux
sensitivity to pulsars slower than 50 ms was 0.2 mJy. No new pulsars were found
in the survey. The size of the survey, combined with the high sensitivity of
the observations, sets a significant constraint on the probability, , of a
runaway OB star having an observable pulsar companion. We find \%
with 95\% confidence, if the general pulsar luminosity function is applicable
to OB star pulsar companions. If a pulsar beaming fraction of \onethird\ is
assumed, then we estimate that fewer than 20\% of runaway OB stars have neutron
star companions, unless pulsed radio emission is frequently obscured by the OB
stellar wind. Our result is consistent with the dynamical (or cluster) ejection
model for the formation of OB runaways. The supernova ejection model is not
ruled out, but is constrained by these observations to allow only a small
binary survival fraction, which may be accommodated if neutron stars acquire
significant natal kicks. According to Leonard, Hills and Dewey (1994), a 20\%
survival fraction corresponds to a 3-d kick velocity of 420 km s. This
value is in close agreement with recent revisions of the pulsar velocity
distribution.Comment: Submitted to the Astronomical Journal. 16 pages. Latex uses
aaspp4.sty. 3 postscript figures. Address correspondence to Colin Philp
([email protected]). Revision was to replace .ps file with latex fil
Catalytic mechanism of Escherichia coli isopentenyl diphosphate isomerase involves Cys-67, Glu-116, and Tyr-104 as suggested by crystal structures of complexes with transition state analogues and irreversible inhibitors
Journal ArticleIsopentenyl diphosphate (IPP):dimethylallyl diphosphate (DMAPP) isomerase is a key enzyme in the biosynthesis of isoprenoids. The reaction involves protonation and deprotonation of the isoprenoid unit and proceeds through a carbocationic transition state. Analysis of the crystal structures (2 A) of complexes of Escherichia coli IPP.DMAPPs isomerase with a transition state analogue (N,N-dimethyl-2-amino-1-ethyl diphosphate) and a covalently attached irreversible inhibitor (3,4-epoxy-3-methyl-1-butyl diphosphate) indicates that Glu-116, Tyr-104, and Cys-67 are involved in the antarafacial addition/elimination of protons during isomerization. This work provides a new perspective about the mechanism of the reaction
Farnesyl pyrophosphate synthetase. Mechanistic studies of the 1'-4 coupling reaction with 2-fluorogeranyl pyrophosphate.
Journal ArticleThe mechanism of the 1'-4 coupling reaction between isopentenyl pyrophosphate and geranyl pyrophosphate catalyzed by farnesyl pyrophosphate synthetase from porcine liver was studied with the allylic substrate analogue 2-fluorogeranyl pyrophosphate. 2-Fluorogeranyl pyrophosphate is an alternate substrate for the enzyme, yielding 6-fluorofarnesyl pyrophosphate upon condensation with isopentenyl pyrophosphate. The Michaelis constant for the fluoroanalogue, Km = 1.1 micron, is similar to that measured for geranyl pyrophosphate, Km = 0.7 micron. However, the rate of condensation with the fluoroanalogue was only 8.4 X 10(-4) that of the normal reaction. A similar rate of depression (4.4 X 10(-3)) was found for solvolysis of geranyl methanesulfonate and the corresponding 2-fluoro derivative, reactions known to proceed via cationic intermediates. In contrast, displacement of chlorine from geranyl chloride and 2-fluorogeranyl chloride by cyanide showed a small (2-fold) rate enhancement for the fluoro compound. Finally, 2-fluorogeranyl pyrophosphate is a competitive inhibitor against geranyl pyrophosphate. These data are interpreted in terms of an ionization-condensation-elimination mechanism for the 1'-4 coupling reaction
Specialized osmotic stress response systems involve multiple SigB-like sigma factors in Streptomyces coelicolor
Book Reviews
Reviews of the following books:
The Wilderness from Chamberlain Farm: A Story of Hope for the American Wild by Dean B. Bennett; The French Baron of Pentagouet: Baron St. Castin and the Struggle for Empire in Early New England by Ailene S. Taylor; Bold Vision: The Development of the Parks of Portland, Maine, edited by Theo H.B.M. Holtwijk and Earle G. Shettleworth, Jr.; Charles Nolcini: The Life and Music of an Italian American in the Age of Jackson by Vincent A. Lapomarda; A Most Remarkable Mix: Sketches of Notable Freeporters by John D. Davi
IMPACTS OF SUPPLEMENTAL FEEDING ON THE NUTRITIONAL ECOLOGY OF BLACK BEARS
Black bear (Ursus americanus) damage to managed conifer stands during the spring in the U.S. Pacific Northwest is a continuing management concern. Because bear damage to managed conifers may reflect the limited availability of nutritious foods, supplemental feeding has been used to decrease damage. Highly palatable, pelleted feed is provided ad libitum from April until late June when berries ripen and such damage stops. We examined black bear use of supplemental feed during the spring and summer of 1998 and 1999 in western Washington. Bears were captured in areas where supplemental feed was provided and in control areas where no effort to reduce conifer damage occurred. Mass gains for bears captured twice were 153 ± 119 g/day (x̅± SD) in the fed areas and 12 ± 104 g/day in non-fed areas. Fat gain for bears in the fed areas was 42 ± 50 g/day and 4 ± 59 g/day in the non-fed areas. However, because age-specific body masses and fat content did not differ between the 2 areas, short-term pellet feeding probably has no long-lasting effect on bear condition or productivity. The diet of bears in the fed areas was 55 ± 22% pelleted feed, 7 ± 7% animal matter, and 38 ± 18% vegetation. The diet of bears in the non-fed areas was 13 ± 17% animal matter and 87 ± 17% vegetation. Grass and sedge composed the majority of vegetation consumed in both areas. The energy content of Douglas-fir (Pseudotsuga menziesii) and western hemlock ( Tsuga heterophylla) sapwood was more digestible (60-67%) than grasses and forbs (18-47%). Smaller bears (adult females and subadult males and females) may do most of the damage because sapwood harvesting rates minimize nutritional gain to larger adult males
A Spitzer IRAC Census of the Asymptotic Giant Branch Populations in Local Group Dwarfs. II. IC 1613
We present Spitzer Space Telescope IRAC photometry of the Local Group dwarf
irregular galaxy IC 1613. We compare our 3.6, 4.5, 5.8, and 8.0 micron
photometry with broadband optical photometry and find that the optical data do
not detect 43% and misidentify an additional 11% of the total AGB population,
likely because of extinction caused by circumstellar material. Further, we find
that a narrowband optical carbon star study of IC 1613 detects 50% of the total
AGB population and only considers 18% of this population in calculating the
carbon to M-type AGB ratio. We derive an integrated mass-loss rate from the AGB
stars of 0.2-1.0 x 10^(-3) solar masses per year and find that the distribution
of bolometric luminosities and mass-loss rates are consistent with those for
other nearby metal-poor galaxies. Both the optical completeness fractions and
mass-loss rates in IC 1613 are very similar to those in the Local Group dwarf
irregular, WLM, which is expected given their similar characteristics and
evolutionary histories.Comment: Accepted by ApJ, 26 pages, 10 figures, version with high-resolution
figures available at: http://webusers.astro.umn.edu/~djackson
Recommended from our members
The Civil Rights Restoration Act of 1987: Legal Analysis of S.557
The Senate i n January 1988 passed S. 557 with amendments to “restore the...broad institution – wide application" of certain federal civil rights laws in the wake of t h e U.S. Supreme Court ruling in Grove City College v. Bell . This report discusses the background and contents of this legislation
Evaluation of the use of patient-focused simulation for student assessment in a surgery clerkship.
BACKGROUND: The purpose of this study was to evaluate the use of simulated patients in conjunction with anatomic and tissue task-training models to assess skills.
METHODS: Faculty reviewed the objectives of the clerkship to identify skills to be acquired. Three cases were developed related to rectal examination, suturing, and inserting intravenous lines and nasogastric tubes. Student scores were based on their ability to gather data from simulated patients and perform procedures on simulation models.
RESULTS: A total of 670 students were assessed between 2006 and 2009. Alpha reliability coefficients were .97 for Communication/Interpersonal Skills, .71 for Procedures, and .58 for Data Gathering. Students receiving low ratings from faculty in the clerkship had significantly (P \u3c .001) lower simulation scores. There were significant (P \u3c .001) relationships between scores and grades in other clerkships.
CONCLUSIONS: The combination of simulated patients and simulation models yielded reliable scores for procedural and interpersonal skills, and evidence of validity related to clinical ratings
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