Supersymmetric Quantum Mechanics for String-Bits

We develop possible versions of supersymmetric single particle quantum mechanics, with application to superstring-bit models in view. We focus principally on space dimensions $d=1,2,4,8$, the transverse dimensionalities of superstring in $3,4,6,10$ space-time dimensions. These are the cases for which ``classical'' superstring makes sense, and also the values of $d$ for which Hooke's force law is compatible with the simplest superparticle dynamics. The basic question we address is: When is it possible to replace such harmonic force laws with more general ones, including forces which vanish at large distances? This is an important question because forces between string-bits that do not fall off with distance will almost certainly destroy cluster decomposition. We show that the answer is affirmative for $d=1,2$, negative for $d=8$, and so far inconclusive for $d=4$.Comment: 17 pages, Late

Universality and Clustering in 1+1 Dimensional Superstring-Bit Models

We construct a 1+1 dimensional superstring-bit model for D=3 Type IIB superstring. This low dimension model escapes the problems encountered in higher dimension models: (1) It possesses full Galilean supersymmetry; (2) For noninteracting polymers of bits, the exactly soluble linear superpotential describing bit interactions is in a large universality class of superpotentials which includes ones bounded at spatial infinity; (3) The latter are used to construct a superstring-bit model with the clustering properties needed to define an $S$-matrix for closed polymers of superstring-bits.Comment: 11 pages, Latex documen

Identifying wildlife reservoirs of neglected taeniid tapeworms : non-invasive diagnosis of endemic Taenia serialis infection in a wild primate population

Despite the global distribution and public health consequences of Taenia tapeworms, the life cycles of taeniids infecting wildlife hosts remain largely undescribed. The larval stage of Taenia serialis commonly parasitizes rodents and lagomorphs, but has been reported in a wide range of hosts that includes geladas (Theropithecus gelada), primates endemic to Ethiopia. Geladas exhibit protuberant larval cysts indicative of advanced T. serialis infection that are associated with high mortality. However, non-protuberant larvae can develop in deep tissue or the abdominal cavity, leading to underestimates of prevalence based solely on observable cysts. We adapted a non-invasive monoclonal antibody-based enzyme-linked immunosorbent assay (ELISA) to detect circulating Taenia spp. antigen in dried gelada urine. Analysis revealed that this assay was highly accurate in detecting Taenia antigen, with 98.4% specificity, 98.5% sensitivity, and an area under the curve of 0.99. We used this assay to investigate the prevalence of T. serialis infection in a wild gelada population, finding that infection is substantially more widespread than the occurrence of visible T. serialis cysts (16.4% tested positive at least once, while only 6% of the same population exhibited cysts). We examined whether age or sex predicted T. serialis infection as indicated by external cysts and antigen presence. Contrary to the female-bias observed in many Taenia-host systems, we found no significant sex bias in either cyst presence or antigen presence. Age, on the other hand, predicted cyst presence (older individuals were more likely to show cysts) but not antigen presence. We interpret this finding to indicate that T. serialis may infect individuals early in life but only result in visible disease later in life. This is the first application of an antigen ELISA to the study of larval Taenia infection in wildlife, opening the doors to the identification and description of infection dynamics in reservoir populations

String Bit Models for Superstring

We extend the model of string as a polymer of string bits to the case of superstring. We mainly concentrate on type II-B superstring, with some discussion of the obstacles presented by not II-B superstring, together with possible strategies for surmounting them. As with previous work on bosonic string we work within the light-cone gauge. The bit model possesses a good deal less symmetry than the continuous string theory. For one thing, the bit model is formulated as a Galilei invariant theory in $(D-2)+1$ dimensional space-time. This means that Poincar\'e invariance is reduced to the Galilei subgroup in $D-2$ space dimensions. Naturally the supersymmetry present in the bit model is likewise dramatically reduced. Continuous string can arise in the bit models with the formation of infinitely long polymers of string bits. Under the right circumstances (at the critical dimension) these polymers can behave as string moving in $D$ dimensional space-time enjoying the full $N=2$ Poincar\'e supersymmetric dynamics of type II-B superstring.Comment: 43 pages, phyzzx require

The Artist as Philanthropist: Strengthening the Next Generation of Artist-Endowed Foundations, Study Report Supplement 2013

This new publication presents updated findings of the Aspen Institute National Study of Artist-Endowed Foundations, reflecting the field's continued growth since release of the Study's initial findings based on 2005 data. Drawing on new data through 2010, Study Report Supplement 2013 details this growth, analyzes factors shaping it, and explores ramifications for foundation practice. Appendices list identified foundations and present data profiles of those reporting assets of at least $1 million. New briefing papers address rising topics that will influence the field's development and a descriptive survey summarizes estate planning literature as it pertains to visual artists

Extraction, separation, and concentration of some anterior pituitary hormones

Publication authorized November 16, 1942.Digitized 2007 AES.Includes bibliographical references (pages 67-76)

Maize leaf PPDK regulatory protein isoform-2 is specific to bundle sheath chloroplasts and paradoxically lacks a Pi-dependent PPDK activation activity

In C4 plants, the pyruvate phosphate dikinase regulatory protein (PDRP) regulates the C4 pathway enzyme pyruvate phosphate dikinase (PPDK) in response to changes in incident light intensity. In maize (Zea mays) leaves, two distinct isoforms of PDRP are expressed, ZmPDRP1 and ZmPDRP2. The properties and C4 function of the ZmPDRP1 isoform are well understood. However, the PDRP2 isoform has only recently been identified and its properties and function(s) in maize leaves are unknown. We therefore initiated an investigation into the maize PDRP2 isoform by performing a side by side comparison of its enzyme properties and cell-specific distribution with PDRP1. In terms of enzyme functionality, PDRP2 was found to possess the same protein kinase-specific activity as PDRP1. However, the PDRP2 isoform was found to lack the phosphotransferase activity of the bifunctional PDRP1 isoform except when PDRP2 in the assays is elevated 5- to 10-fold. A primarily immuno-based approach was used to show that PDRP1 is strictly expressed in mesophyll cells and PDRP2 is strictly expressed in bundle sheath strand cells (BSCs). Additionally, using in situ immunolocalization, we establish a regulatory target for PDRP2 by showing a significant presence of C4 PPDK in BSC chloroplasts. However, a metabolic role for PPDK in this compartment is obscure, assuming PPDK accumulating in this compartment would be irreversibly inactivated each dark cycle by a monofunctional PDRP2

N-band Imaging of Seyfert Nuclei and the MIR-X-ray correlation

We present new mid-infrared (N-band) images of a sample of eight nearby Seyfert galaxies. In all of our targets, we detect a central unresolved source, which in some cases has been identified for the first time. In particular, we have detected the mid-infrared emission from the active nucleus of NGC 4945, which previously remained undetected at any wavelength but hard X-rays. We also detect circumnuclear extended emission in the Circinus galaxy along its major axis, and find marginal evidence for extended circumnuclear emission in NGC 3281. The high spatial resolution (1.7") of our data allows us to separate the flux of the nuclear point sources from the extended circumnuclear starburst (if present). We complement our sample with literature data for a number of non-active starburst galaxies, and relate the nuclear N-band flux to published hard (2-10 kev) X-ray fluxes. We find tight and well-separated correlations between nuclear N-band flux and X-ray flux for both Seyfert and starburst nuclei which span over 3 orders of magnitude in luminosity. We demonstrate that these correlations can be used as a powerful classification tool for galactic nuclei. For example, we find strong evidence against NGC 1808 currently harbouring an active Seyfert nucleus based on its position in the mid-infrared-X-ray diagram. On the other hand, we confirm that NGC 4945 is in fact a Seyfert 2 galaxy.Comment: 31 pages, incl. 4 figures, uses AASTex. Replaced with accepted version after minor modifications. To appear in Ap

Pyruvate Dehydrogenase Kinase 4: Regulation by Thiazolidinediones and Implication in Glyceroneogenesis in Adipose Tissue

OBJECTIVE—Pyruvate dehydrogenase complex (PDC) serves as the metabolic switch between glucose and fatty acid utilization. PDC activity is inhibited by PDC kinase (PDK). PDC shares the same substrate, i.e., pyruvate, as glyceroneogenesis, a pathway controlling fatty acid release from white adipose tissue (WAT). Thiazolidinediones activate glyceroneogenesis. We studied the regulation by rosiglitazone of PDK2 and PDK4 isoforms and tested the hypothesis that glyceroneogenesis could be controlled by PDK

Modularity and Intrinsic Evolvability of Hsp90-Buffered Change

Hsp90 controls dramatic phenotypic transitions in a wide array of morphological features of many organisms. The genetic-background dependence of specific abnormalities and their response to laboratory selection suggested Hsp90 could be an ‘evolutionary capacitor’, allowing developmental variation to accumulate as neutral alleles under normal conditions and manifest selectable morphological differences during environmental stress. The relevance of Hsp90-buffered variation for evolution has been most often challenged by the idea that large morphological changes controlled by Hsp90 are unconditionally deleterious. To address this issue, we tested an Hsp90-buffered abnormality in Drosophila for unselected pleiotropic effects and correlated fitness costs. Up to 120-fold differences in penetrance among six highly related selection lines, started from an initially small number of flies and rapidly selected for and against a deformed eye trait (dfe), did not translate into measurable differences in any of several tests of viability, lifespan or competitive fitness. Nor were 17 dfe Quantitative Trait Loci (QTL) associated with fitness effects in over 1,400 recombinant lines. Our ability to detect measurable effects of inbreeding, media environment and the white mutation in the selection line backgrounds independent of dfe penetrance suggests that, within the limitations of laboratory tests of fitness, this large morphological change controlled by Hsp90 was selectable independent of strong, correlated and unconditionally deleterious effects—abundant, polygenic variation hidden by Hsp90 allows potentially deleterious alleles to be readily replaced during selection by less deleterious alleles with similar phenotypic effects. Hsp90 links environmental stress with the expression of developmental variation controlling unprecedented morphological plasticity. As outlined here and in the companion paper of this issue, the complex genetic architecture of Hsp90-buffered variation supports a remarkable modularity of Hsp90 effects on quantitative and qualitative phenotypes, consistent with the ‘Hsp90 capacitor hypothesis’ and standard quantitative genetic models of threshold traits