Korean lespedeza in Missouri

Cover title

A classification of soybeans

Publication authorized November 7, 1929.Includes index

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule.

Selective degradation of damaged mitochondria by autophagy (mitophagy) is proposed to play an important role in cellular homeostasis. However, the molecular mechanisms and the requirement of mitochondrial quality control by mitophagy for cellular physiology are poorly understood. Here, we demonstrated that primary human cells maintain highly active basal mitophagy initiated by mitochondrial superoxide signaling. Mitophagy was found to be mediated by PINK1/Parkin-dependent pathway involving p62 as a selective autophagy receptor (SAR). Importantly, this pathway was suppressed upon the induction of cellular senescence and in naturally aged cells, leading to a robust shutdown of mitophagy. Inhibition of mitophagy in proliferating cells was sufficient to trigger the senescence program, while reactivation of mitophagy was necessary for the anti-senescence effects of NAD precursors or rapamycin. Furthermore, reactivation of mitophagy by a p62-targeting small molecule rescued markers of cellular aging, which establishes mitochondrial quality control as a promising target for anti-aging interventions. [Abstract copyright: Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.

Suppressed basal mitophagy drives cellular aging phenotypes that can be reversed by a p62-targeting small molecule

journal articl

Printing Roller Cleaning Device.

Patent for a cleaning device designed to expedite the cleaning of printing press rollers

Crystal Structures of A₂FeCl₅·H₂O (A=Rb⁺, Cs⁺) and Field Dependent Superconducting Susceptometer Measurements

Crystal structures and low field principal crystal axis magnetic measurements are reported for the antiferromagnetic iron (III) salts A2FeCl5·H2O; A=Rb+, Cs+. The two compounds undergo a zero field paramagnetic to antiferromagnetic phase transition at 6.5 K (A=Cs+) and 10.05 K (A=Rb+). The spin flop magnetic phase is observed in high field measurements. The magnetic field-temperature phase diagrams are reported. All magnetic measurements were recorded on a superconducting susceptometer. The bicritical points are 6.25 K, 14.5 kOe (A=Cs+), 9.75 K, 17.8 KOe (A=Rb+). Crystal data for Cs2FeCl5· H2O: space group Cmcm, Z = 4, a = 7.442(3) Å, b = 17.307(7) Å, c = 8.077(7) Å, V = 1040 Å3, R = 5.2%, 561 reflections. Crystal data for Rb2FeCl5·H2O, space group Pnma, Z = 4, a = 13.825(4) Å, b = 9.918(3) Å, c = 7.100(2) Å, V = 4.9 Å3, 5.7%, 712 reflections